Cerebellitis in an Adult With Abnormal Magnetic Resonance Imaging Findings Prior to the Onset of Ataxia

Gruis, Kirsten L.; Moretti, Paolo; Gebarśki, Stephen S.; Mikol, Daniel D.

doi:10.1001/archneur.60.6.877

Cited by 28 publications

(11 citation statements)

References 13 publications

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“…AC has also been described following administration of intermediate-dose cytarabine [21]. However, in most of the cases a definite etiology remains undetermined [26], which is demonstrated in our review. In only 24% (8/33), a proven infectious agent could be found.…”

Section: Discussionsupporting

confidence: 53%

“…SanPedro et al [15] also reported on a case with decreased cerebellar blood flow. Gruis et al [26], however, reported on a case with increased cerebellar blood flow; cerebellar hyperperfusion could then be explained by the inflammatory component of cerebellitis. Further investigations have to be done to understand the pathogenesis of AC and to establish the value of perfusion-SPECT in AC.…”

Section: Discussionmentioning

confidence: 98%

“…It is well known that MRI is more sensitive to assess the brainstem and cerebellum. and rubella are the most common etiologic infectious agents described in children [26]. Other pathogens associated with cerebellar inflammation and edema include influenza, para influenza, poliovirus, Coxsackie, herpes simplex virus, herpes zoster virus, cytomegalovirus, EpVarious patterns of cerebellar involvement have been reported.…”

Section: Discussionmentioning

confidence: 99%

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MRI findings in acute cerebellitis

Bruecker¹,

Claus²,

Demaerel³

et al. 2004

Eur Radiol

112

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Acute cerebellitis is an inflammatory process involving the cerebellum. We report the clinical, CT and MRI features of four cases and a review of the literature. Bilateral diffuse hemispheric abnormalities represent the most common imaging presentations. Our observations demonstrate the various imaging appearances of acute cerebellitis. Simultaneous involvement of both hemispheres and the vermis has not been reported previously. The development of cerebellar atrophy following an initial normal MR imaging examination is also a new finding. In atypical clinical presentation, MR imaging can lead to the diagnosis. MR imaging findings have, however, no prognostic value.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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MRI findings in acute cerebellitis

Bruecker¹,

Claus²,

Demaerel³

et al. 2004

Eur Radiol

112

View full text Add to dashboard Cite

show abstract

“…The decreased cerebellar blood flow could be explained by a post-infectious demyelinating autoimmune response 1. Whereas, Gruis et al14 reported on a case with increased cerebellar blood flow, reflecting the inflammatory component of cerebellitis.…”

Section: Discussionmentioning

confidence: 99%

An Elderly Case of Acute Cerebellitis after Alleged Vaccination

Park

Kim

Kim³

2012

JMD

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Acute cerebellitis (AC) is a benign and self-limiting inflammatory disease. It typically occurs as a primary infectious or postinfectious disorder. Although AC mostly presents in early childhood, it can appear in adult. A 66-year-old man admitted to our hospital because of limb and gait ataxia. Three weeks ago, he took an influenza vaccination. There was no abnormality on brain MRI with contrast enhancement, but Technetium-99m hexamethyl propylene amine oxime-single photon emission computed tomography (HMPAO-SPECT) showed markedly cerebellar asymmetry, suggesting hypoperfusion in the right cerebellum. Influenza vaccination can cause AC in the elderly and brain HMPAO-SPECT imaging is more useful than MRI in identifying patients with AC.

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“…To the best of our knowledge, the oldest previously reported case was of a 66-year-old Korean man with post-influenza vaccination cerebellitis. 15 Gruis et al 5 reported a case of postinfectious cerebellitis in a 38-year-old woman. Pseudotumoral hemicerebellitis represents a rare manifestation of acute cerebellitis in which a unilateral cerebellar expansive, infiltrative lesion mimics a tumor exerting mass effect on the surrounding structures.…”

Section: Discussionmentioning

confidence: 99%

Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression

Gupta

Maralani²,

Chawla³

et al. 2014

JNS

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Acute cerebellitis is an inflammatory process that usually affects bilateral cerebellar hemispheres in the pediatric population. Pseudotumoral hemicerebellitis is an extremely rare presentation in which unilateral cerebellar involvement mimics a tumor that can exert significant mass effect on the surrounding structures, which may require surgical intervention. Magnetic resonance imaging characteristics that suggest cerebellitis include cerebellar swelling, T2 hyperintensity, and pial enhancement. Advanced neuroimaging, including MR perfusion and MR spectroscopy, may be helpful in excluding other diagnoses. The authors present the case of pseudotumoral hemicerebellitis in the oldest documented patient, a 73-year-old man who required surgical decompression, and they provide a brief discussion of advanced neuroimaging findings. Key woRDs • cerebellitis • advanced neuroimaging • MR spectroscopy • MR perfusion • surgical decompression • infectionAbbreviations used in this paper: CBF = cerebral blood flow; Cho = choline; Cr = creatine; CRP = C-reactive protein; ESR = erythrocyte sedimentation rate; LDD = Lhermitte-Duclos disease; MRS = magnetic resonance spectroscopy; NAA = N-acetylaspartate; ppm = parts per million.

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Cerebellitis in an Adult With Abnormal Magnetic Resonance Imaging Findings Prior to the Onset of Ataxia

Abstract: This case demonstrates that transient abnormalities can be detected by MRI before clinical manifestations of cerebellitis appear, while hyperperfusion detected by single-photon emission computed tomography is prolonged.

Cited by 28 publications

References 13 publications

MRI findings in acute cerebellitis

MRI findings in acute cerebellitis

An Elderly Case of Acute Cerebellitis after Alleged Vaccination

Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression

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