Cerebellifugal Fibres to the Cochlear Nuclei and Superior Olivary Complex

Rossi, Giovanni; Cortesina, G; Robecchi, Maria G. Giacobini

doi:10.3109/05384916709074285

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…Subsequent physiological studies have confirmed the same result across different animal species [Aitikin and Boyd, 1975;Huang and Liu, 1990;Sun et al, 1983;Wolfe and Kos, 1975;Xi et al, 1994]. It has also been demonstrated anatomically that the cochlear nucleus, the first relay nucleus along the auditory pathway, sends efferents directly to the cerebellum [Huang et al, 1982] and together with the ᭜ Petacchi et al ᭜ ᭜ 124 ᭜ superior olive directly receives retrograde cerebellifugal projections [Gacek, 1973;Rossi et al, 1967]. Although the functional significance of this direct cerebellar projection close to the auditory periphery has been little considered, it has been shown that the cerebellum can exert an inhibitory effect on the auditory nerve action potentials and on cochlear microphonics [Velluti and Crispino, 1979].…”

Section: Anatomical and Physiological Support For The Cerebellar Imagsupporting

confidence: 53%

Cerebellum and auditory function: An ALE meta‐analysis of functional neuroimaging studies

Petacchi

Laird

Fox³

et al. 2005

Human Brain Mapping

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174

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Abstract:Over the past two decades neuroimaging data have accumulated showing that the cerebellum, traditionally viewed only as a motor structure, is also active in a wide variety of sensory and cognitive tasks. We have proposed that instead of explicit involvement in any particular motor, sensory, or cognitive task, the cerebellum performs a much more fundamental computation involving the active acquisition of sensory data. We carried out an activation likelihood estimate (ALE) meta-analysis to determine whether neuroimaging results obtained during a wide range of auditory tasks support this proposal. Specifically, we analyzed the coordinates of 231 activation foci obtained in 15 different auditory studies selected through an extensive search of the positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) literature. The studies selected represent a wide variety of purely auditory tasks using highly controlled synthesized acoustic stimuli. The results clearly revealed that in addition to temporal auditory areas of cerebral cortex, specific regions in the cerebellum are activated consistently across studies regardless of the particular auditory task involved. In particular, one area in left lateral crus I area showed the greatest volume and ALE peak value among the extratemporal regions. A subanalysis was carried out that ruled out the specific association of this cerebellar cluster with attentional demand. The results are consistent with the hypothesis that the cerebellum may play a role in purely sensory auditory processing, and are discussed in light of the broader idea of the cerebellum subserving a fundamental sensory function. Hum Brain Mapp 25:118 -128, 2005.

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Section: Anatomical and Physiological Support For The Cerebellar Imagsupporting

confidence: 53%

Cerebellum and auditory function: An ALE meta‐analysis of functional neuroimaging studies

Petacchi

Laird

Fox³

et al. 2005

Human Brain Mapping

206

174

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“…However, the extent to which these would have been removed was assessed by evaluating the extent of the transection of the olivocochlear bundle as it traverses the brainstem, at a location distal to where its strial branch exits but definitely before the exit of the ventral branch connections to the cochlear nucleus. Connections from the cerebellum to the cochlear nucleus were not specifically cut, but these appear to connect mostly to the ventral cochlear nucleus (VCN; Rasmussen, 1967; Rossi et al, 1967; Gacek, 1973). Based on the degree of transection of descending projections, both control and exposed animals were divided into the following three experimental subgroups: 1) animals without sectioning (no surgical sectioning was performed to separate the DCN from its adjacent brainstem structures), 2) animals with partial sectioning (incomplete transection of brainstem tracts near the DCN was achieved), and 3) animals with complete or nearly complete sectioning (the DCN was completely or nearly completely isolated from the adjacent brainstem structures).…”

Section: Methodsmentioning

confidence: 99%

“…Sources of these auditory inputs include the contralateral cochlear nucleus (Adams and Warr, 1976; Cant and Gaston, 1982; Wenthold, 1987; Shore et al, 1992; Alibardi, 2000; Arnott et al, 2004), superior olivary complex (Starr and Wernick, 1968; Brown et al, 1988; Sherriff and Henderson, 1994; Ostapoff et al, 1997), inferior colliculi (Rasmussen, 1960; Conlee and Kane, 1982; Faye‐Lund, 1988; Caicedo and Herbert, 1993), nuclei of the lateral lemniscus (Rasmussen, 1960; Kane, 1977), and primary auditory cortex (Weedman and Ryugo, 1996). Sources of nonauditory inputs include the mesencephalic reticular formation (Gonzalez‐Lima and Scheich, 1984), locus coeruleus (Kromer and Moore, 1980; Ebert, 1996), cuneate nucleus (Weinberg and Rustioni, 1987; Wright and Ryugo, 1996), trigeminal nucleus (Itoh et al, 1987; Li and Mizuno, 1997; Zhou and Shore, 2004), trigeminal ganglion (Shore, 2005), dorsal raphe nucleus (Thompson and Thompson, 2001; Ye and Kim, 2001), and cerebellum (Rasmussen, 1967; Rossi et al, 1967; Gacek, 1973). The purpose of the current study was to test whether DCN hyperactivity is dependent on any of these descending inputs to the DCN.…”

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confidence: 99%

Origin of hyperactivity in the hamster dorsal cochlear nucleus following intense sound exposure

Zhang

Kaltenbach

Godfrey

et al. 2006

J of Neuroscience Research

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This study sought to determine whether maintenance of noise-induced dorsal cochlear nucleus (DCN) hyperactivity depends on descending projections. Twenty-two hamsters were exposed under anesthesia to a 10-kHz tone at 125-130 dB SPL for 4 hr, and another 21 unexposed animals served as controls. After approximately 4-6 weeks of recovery, surgical transections were made to isolate the DCN from its adjacent brainstem structures. Spontaneous multiunit activity was recorded from the DCN surface 30-40 min after the surgical manipulations. Spontaneous rates were derived from the recording sites of the DCN along its mediolateral axis for each animal, yielding average spontaneous rates for both control and exposed groups. Histology was performed to assess the degree of sectioning of descending fiber tract connections to the cochlear nucleus, via the acoustic striae route, subpeduncular route, trapezoid body route, and ventral route of the olivocochlear bundle connection. The results showed that complete or nearly complete transections of descending inputs did not affect significantly the magnitude of DCN hyperactivity. However, this manipulation triggered a lateral shift of the peak mean rate, suggesting that descending inputs may play a modulatory role on the profile of DCN hyperactivity. Indeed, exposed animals with transection of only the strial route of entry manifested a level of hyperactivity much higher than that observed in exposed animals in which no sections were performed. This enhancement of DCN hyperactivity was weakened by damage to the subpeduncular or trapezoid routes of input, suggesting that the dorsally located inputs may have an inhibitory effect on DCN hyperactivity.

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“…The connections between the cerebellum and the cerebral cortex are composed of feedforward (the corticopontine-pontocerebellar circuit) and feedback (the cerebellothalamic-thalamocortical circuit) loops, which are the anatomic foundations of the involvement of the cerebellum in sensory perception (Baumann et al, 2015 ). The cerebellum is structurally connected to the cochlear nucleus (Huang et al, 1982 ), superior olivary nucleus (Rossi et al, 1967 ), inferior colliculus (Ruchalski and Hathout, 2012 ), medial geniculate body (Keifer et al, 2015 ) and the auditory cortex (Huffman and Henson, 1990 ), either directly or indirectly. This suggests that the cerebellum could impact the signal from the peripheral hearing organs or modulate the activity of the acoustic center.…”

Section: Introductionmentioning

confidence: 99%

Increased Resting-State Cerebellar-Cerebral Functional Connectivity Underlying Chronic Tinnitus

Feng¹,

Chen²,

Lv³

et al. 2018

Front. Aging Neurosci.

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Purpose: Chronic subjective tinnitus may arise from aberrant functional coupling between the cerebellum and the cerebral cortex. To explore this hypothesis, we used resting-state functional magnetic resonance imaging (fMRI) to illuminate the functional connectivity network of the cerebellar regions in chronic tinnitus patients and controls.Methods: Resting-state fMRI scans were obtained from 28 chronic tinnitus patients and 29 healthy controls (well matched for age, sex and education) in this study. Cerebellar-cerebral functional connectivity was characterized using a seed-based whole-brain correlation method. The resulting cerebellar functional connectivity measures were correlated with each clinical tinnitus characteristic.Results: Chronic tinnitus patients demonstrated increased functional connectivity between the cerebellum and several cerebral regions, including the superior temporal gyrus (STG), parahippocampal gyrus (PHG), inferior occipital gyrus (IOG), and precentral gyrus. The enhanced functional connectivity between the left cerebellar Lobule VIIb and the right STG was positively correlated with the Tinnitus Handicap Questionnaires (THQ) score (r = 0.577, p = 0.004). Furthermore, the increased functional connectivity between the cerebellar vermis and the right STG was also associated with the THQ score (r = 0.432, p = 0.039).Conclusions: Chronic tinnitus patients have greater cerebellar functional connectivity to certain cerebral brain regions which is associated with specific tinnitus characteristics. Resting-state cerebellar-cerebral functional connectivity disturbances may play a pivotal role in neuropathological features of tinnitus.

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Cerebellifugal Fibres to the Cochlear Nuclei and Superior Olivary Complex

Cited by 4 publications

References 15 publications

Cerebellum and auditory function: An ALE meta‐analysis of functional neuroimaging studies

Cerebellum and auditory function: An ALE meta‐analysis of functional neuroimaging studies

Origin of hyperactivity in the hamster dorsal cochlear nucleus following intense sound exposure

Increased Resting-State Cerebellar-Cerebral Functional Connectivity Underlying Chronic Tinnitus

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