Cerebellar volume change in response to electroconvulsive therapy in patients with major depression

Depping, Malte S.; Nolte, Henrike Maria; Hirjak, Dušan; Palm, Elisa; Hofer, Stefan; Stieltjes, Bram; Maier‐Hein, Klaus H.; Sambataro, Fabio; Thomann, Philipp A.

doi:10.1016/j.pnpbp.2016.09.007

Cited by 39 publications

(28 citation statements)

References 36 publications

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“…The distinct characteristics between our study and the studies described in the meta‐analyses could have led to these opposing conclusions. First, the meta‐analyses and reviews based their conclusions on four relatively small studies , , , compared to our sample size, and could, therefore, be underpowered. Second, the studies investigated mainly executive functioning , , , rather than memory compared to our study, or they included only one measure of cognition, the MMSE .…”

Section: Discussionmentioning

confidence: 99%

“…First, the meta‐analyses and reviews based their conclusions on four relatively small studies , , , compared to our sample size, and could, therefore, be underpowered. Second, the studies investigated mainly executive functioning , , , rather than memory compared to our study, or they included only one measure of cognition, the MMSE . Finally, the studies explored the relation between regional volumetric changes post‐ECT and cognition only secondary to their a priori hypotheses, and were therefore not optimally designed for detecting associations between volumetric changes and ECT‐related cognitive effects.…”

Section: Discussionmentioning

confidence: 99%

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Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Laroy

Bouckaert

Vansteelandt

et al. 2019

Acta Psychiatr Scand

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Laroy M, Bouckaert F, Vansteelandt K, et al. Association between hippocampal volume change and change in memory following electroconvulsive therapy in late-life depression.Objective: Electroconvulsive therapy (ECT)-induced hippocampal volume change (HVC) has been repeatedly described in recent years. The similar time course of HVC and ECT-related cognitive effects suggest a relation, that is to date, understudied. This study investigates whether HVC following ECT predicts the change in memory performance six months after the end of the ECT treatment. Methods: Hippocampal volume (HV) was measured via high-resolution 3D T1weighted images in 88 patients with late-life depression, within 1 week before and after ECT. Memory performance was assessed before and six months after ECT. Multiple linear regression was used to examine whether change in memory performance could be predicted based on ECT-induced changes in HV. Results: Larger right absolute HVC predicts less pronounced improvement on the VAT (visual memory) in the whole sample. For the 8-Word Test (verbal memory), Category Fluency Test (semantic memory), and MMSE, the effect is only present in patients who switched from right unilateral to bitemporal stimulation after six ECT sessions. Absolute HVC in the left hemisphere was not significantly related to cognitive change. Conclusion: A larger absolute change in right HV during ECT is associated with less improvement in memory performance up to 6 months post-ECT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Laroy

Bouckaert

Vansteelandt

et al. 2019

Acta Psychiatr Scand

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“…The circuits that connect the cerebellum to the cerebral cortices and paralimbic regions have been identified (Schmahmann, Weilburg, & Sherman, 2007;Stoodley & Schmahmann, 2009 and WM, particularly in the posterior lobules of the cerebellum (VI and VII; Baldaçara et al, 2008;Grieve et al, 2013). Recently, a study by Malte revealed (Depping et al, 2016(Depping et al, , 2017 that patients with an acute MDD episode have a higher volume in Cerebellar lobule IX, Cerebellar lobule VIII and Cerebellar lobule VIIb than HCs. However, research studies regarding the changes in the cerebellar volume and emotional memory in patients with depression remain scarce.…”

Section: Discussionmentioning

confidence: 99%

“…Lobule VII includes the vermis at the midline and the hemispheric portions of lobules VIIA (Crus I and Crus II) and VIIB. Recently, studies by Depping et al (2016Depping et al ( , 2017 have shown an increased GM volume in lobules VIIA and IX in individuals with MDD. Schutter, Koolschijn, Peper, and Crone (2012) demonstrated that the posterior lobules of the cerebellum are significantly involved in processes that are associated with cognitive and emotional functions.…”

Section: Introductionmentioning

confidence: 99%

Relationship between cerebellar structure and emotional memory in depression

Liu

et al. 2017

Brain and Behavior

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BackgroundA few studies have been conducted on the relationship between cerebellar volume and emotional memory or clinical severity in major depressive disorder (MDD). In this study, we aimed to compare the volume and density of the cerebellar gray matter (GM) in patients with MDD and in healthy controls (HCs) and explore the association between these cerebellar parameters and measurements of emotional memory and clinical severity.MethodVoxel‐based morphometry (VBM) and Individual Brain Atlases using Statistical Parametric Mapping (IBASPM) were used to assess GM density and volume in the cerebellum, respectively, in patients with MDD and the HCs. Indicators of emotional memory performance were measured, including the hit rate (HR), rate of false alarm (FA), precision (Pr = HR − FA) and emotional memory enhancement [∆Pr = Pr(emotion) − Pr(neutral)] values. Beck Depression Inventory (BDI) scores were used to measure the severity of depression.ResultsIn the patients with MDD, the GM density was decreased in three cerebellar cortical regions and increased in three cerebellar cortical regions (p < .005). The GM volumes in eight cerebellar cortical regions were significantly smaller in the patients with MDD than in the HC subjects (p < .05). In the patients with MDD, the GM volume was correlated with the ∆Pr (p < .05) in two cerebellar cortical regions. The BDI scores were significantly correlated with the relative GM densities (p < .05) in 5 cerebellar cortical regions, and the GM volumes in 13 cerebellar cortical regions were correlated with the BDI scores in patients with MDD.ConclusionsEmotional memory and the severity of depressive symptoms are associated with structural changes in both the posterior and anterior GM regions in the cerebellum in patients with MDD. These findings could be useful for improving our understanding of the neurobiological mechanisms underlying emotional memory and explaining the abnormalities of the neural correlates that are associated with MDD.

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“…Even though the cognitive sequelae are transient and ECT does not increase the risk of dementia (Chu et al, 2018), the possibility of cognitive impairment can be dissuasive to an individual with a depressive episode even if they have found no benefit with other antidepressant modalities, particularly for independent-living outpatients. Specific brain regions including the hippocampus (Oltedal et al, 2018), amygdala , striatum (Wade et al, 2016), and cerebellum (Depping et al, 2017), as well as the whole-brain structural changes Ousdal et al, 2019) were investigated following ECT. In addition, single imaging modality (Abbott et al, 2013;Jiang et al, 2018;Leaver et al, 2019;Redlich et al, 2016;Sun et al, 2019;van Waarde et al, 2015) and multimodal analysis (Cano et al, 2017;Jorgensen et al, 2016;Nickl-Jockschat et al, 2016) but with a small sample size (n < 25 patients) have been assessed with treatment response.…”

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confidence: 99%

Electroconvulsive therapy treatment responsive multimodal brain networks

Abbott

Narr

et al. 2020

Human Brain Mapping

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Electroconvulsive therapy is regarded as the most effective antidepressant treatment for severe and treatment‐resistant depressive episodes. Despite the efficacy of electroconvulsive therapy, the neurobiological underpinnings and mechanisms underlying electroconvulsive therapy induced antidepressant effects remain unclear. The objective of this investigation was to identify electroconvulsive therapy treatment responsive multimodal biomarkers with the 17‐item Hamilton Depression Rating Scale guided brain structure–function fusion in 118 patients with depressive episodes and 60 healthy controls. Results show that reduced fractional amplitude of low frequency fluctuations in the prefrontal cortex, insula and hippocampus, linked with increased gray matter volume in anterior cingulate, medial temporal cortex, insula, thalamus, caudate and hippocampus represent electroconvulsive therapy responsive covarying functional and structural brain networks. In addition, relative to nonresponders, responder‐specific electroconvulsive therapy related brain networks occur in frontal‐limbic network and are associated with successful therapeutic outcomes. Finally, electroconvulsive therapy responsive brain networks were unrelated to verbal declarative memory. Using a data‐driven, supervised‐learning method, we demonstrated that electroconvulsive therapy produces a remodeling of brain functional and structural covariance that was unique to antidepressant symptom response, but not linked to memory impairment.

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Cerebellar volume change in response to electroconvulsive therapy in patients with major depression

Cited by 39 publications

References 36 publications

Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Association between hippocampal volume change and change in memory following electroconvulsive therapy in late‐life depression

Relationship between cerebellar structure and emotional memory in depression

Electroconvulsive therapy treatment responsive multimodal brain networks

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