Cerebellar Units Show Several Types of Long-Lasting Posttetanic Responses to Telencephalic Stimulation in Catfish

Lee, Luke T.; Bullock, Theodore H.

doi:10.1159/000115875

Cited by 8 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The contrasting effects of repetitive stimulation may reflect two different in put systems into the cerebellum, mossy and climbing fibers, as emphasized by and Demer et al [1985] in cats. The participation of climbing fi bers in mediating the telencephalocerebellar response to repetitive stimulation in catfish was already sug gested in the study of their evoked field potentials [Lee, 1984], Although the present report reveals complex dy namic properties, it remains to be determined whether or how far these effects are sensitive to the temporal pattern, to high-frequency bursts or to posttetanic re covery phases [Lee and Bullock, 1990],…”

Section: Complex Dynamic Propertiesmentioning

confidence: 61%

Cerebellar Units Show Several Types of Early Responses to Telencephalic Stimulation in Catfish

Lee¹,

Bullock²

1990

Brain Behav Evol

Self Cite

View full text Add to dashboard Cite

The responses of cerebellar units following electrical stimulation applied to the area dorsalis centralis (Dc) of the telencephalon were studied in the siluroid teleost Ictalurus nebulosus. Two kinds of units are distinguished on physiological criteria, identified as Purkinje and eurydendroid cells (the efferent neurons of the cerebellum in teleosts equivalent to cells of the deep nuclei in other vertebrates). A high proportion of both kinds of units in the corpus cerebelli are sensitive to such stimulation. Each kind of unit shows several consistent response types. Purkinje cells fire simple spikes spontaneously at the rate of 8–50 spikes/s and respond to a single shock to Dc with an initial latency of 34–64 ms. The response can be one of the following types: (1) inhibition alone, with a duration of 0.3–1.5 s; (2) initial inhibition for 0.04–0.2 s, followed by postinhibitory rebound, or (3) initial excitation followed by inhibition which may or may not be followed by a late excitation. It is suggested that the initial excitation and initial inhibition reflect the activation of mossy fiber-granule cell-Purkinje cell circuitry and mossy fiber-granule cell-inhibitory interneuron-Purkinje cell circuitry, respectively. Indirect evidence suggests the involvement of climbing fibers, but their characteristic complex spikes are rarely seen. Changing the stimulation sites within Dc does not appear to change the response pattern but may alter the threshold intensities, latencies and amplitudes. Changing stimulation frequency has complex effects depending on the response type. Purkinje cells responding with initial excitation are located along the lateral edges and along the midline of the corpus cerebelli; units responding with initial inhibition are more often found in an intermediate zone. This suggests three sagittal bands on each side. The contralateral cerebellum has a relative excess of Purkinje cells with initially inhibitory response. Putative eurydendroid cells show either initial excitation or a pattern of inhibition, excitation, inhibition. The initial latency is longer than in Purkinje cells. The contralateral cerebellum has a relative excess of eurydendroid cells with initially excitatory responseThe high proportion of units that respond to Dc stimulation, their complex dynamics, diverse response types and compartmentalization point to the importance of the cerebrocerebellar influence in teleosts. Principal differences from mammals are the much longer latencies and less differentiation according to place stimulation in the cerebrum.

show abstract

Section: Complex Dynamic Propertiesmentioning

confidence: 61%