Cerebellar tDCS consistency and metabolite changes: A recommendation to decrease barriers to replicability

Moussa-Tooks, Alexandra B.; Burroughs, Leah; Rejimon, Abinand C.; Cheng, Hu; Hetrick, William P.

doi:10.1016/j.brs.2020.08.005

Cited by 6 publications

(5 citation statements)

References 13 publications

(25 reference statements)

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“…Moreover, righthanded finger-tapping activated right cerebellar lobules IV-V and VIII (Stoodley et al, 2012). In a recent modeling study, the electrode montage used in our current study has consistently been demonstrated to generate an electrical field with its peak strength within cerebellar lobules VII and VIII (Moussa-Tooks et al, 2020).…”

Section: Cerebellar Tdcs Did Not Affect Online Learningsupporting

confidence: 68%

No Impact of Cerebellar Anodal Transcranial Direct Current Stimulation at Three Different Timings on Motor Learning in a Sequential Finger-Tapping Task

Nguemeni

Stiehl

Hiew

et al. 2021

Front. Hum. Neurosci.

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Background: Recently, attention has grown toward cerebellar neuromodulation in motor learning using transcranial direct current stimulation (tDCS). An important point of discussion regarding this modulation is the optimal timing of tDCS, as this parameter could significantly influence the outcome. Hence, this study aimed to investigate the effects of the timing of cerebellar anodal tDCS (ca-tDCS) on motor learning using a sequential finger-tapping task (FTT).Methods: One hundred and twenty two healthy young, right-handed subjects (96 females) were randomized into four groups (Duringsham, Before, Duringreal, After). They performed 2 days of FTT with their non-dominant hand on a custom keyboard. The task consisted of 40 s of typing followed by 20 s rest. Each participant received ca-tDCS (2 mA, sponge electrodes of 25 cm2, 20 min) at the appropriate timing and performed 20 trials on the first day (T1, 20 min). On the following day, only 10 trials of FTT were performed without tDCS (T2, 10 min). Motor skill performance and retention were assessed.Results: All participants showed a time-dependent increase in learning. Motor performance was not different between groups at the end of T1 (p = 0.59). ca-tDCS did not facilitate the retention of the motor skill in the FTT at T2 (p = 0.27). Thus, our findings indicate an absence of the effect of ca-tDCS on motor performance or retention of the FTT independently from the timing of stimulation.Conclusion: The present results suggest that the outcome of ca-tDCS is highly dependent on the task and stimulation parameters. Future studies need to establish a clear basis for the successful and reproducible clinical application of ca-tDCS.

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Section: Cerebellar Tdcs Did Not Affect Online Learningsupporting

confidence: 68%

No Impact of Cerebellar Anodal Transcranial Direct Current Stimulation at Three Different Timings on Motor Learning in a Sequential Finger-Tapping Task

Nguemeni

Stiehl

Hiew

et al. 2021

Front. Hum. Neurosci.

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“…The ctDCS effects are primarily studied based on the impact of the Purkinje cell [ 41 ] under the quasi-uniform assumption that local polarization effect is proportional to the local electric field strength [ 50 ]; however, the local electric field effects on the dentate nuclei should also be considered [ 51 ]. Such cerebellar sub-structure specific investigation of ctDCS electric field is crucial to decrease the barriers to replicability [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating the feasibility of cerebellar transcranial direct current stimulation to facilitate post-stroke overground gait performance in chronic stroke: a partial least-squares regression approach

Solanki

Rezaee

Dutta

et al. 2021

J NeuroEngineering Rehabil

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Background Investigation of lobule-specific electric field effects of cerebellar transcranial direct current stimulation (ctDCS) on overground gait performance has not been performed, so this study aimed to investigate the feasibility of two lobule-specific bilateral ctDCS montages to facilitate overground walking in chronic stroke. Methods Ten chronic post-stroke male subjects participated in this repeated-measure single-blind crossover study, where we evaluated the single-session effects of two bilateral ctDCS montages that applied 2 mA via 3.14 cm2 disc electrodes for 15 min targeting (a) dentate nuclei (also, anterior and posterior lobes), and (b) lower-limb representations (lobules VIIb-IX). A two-sided Wilcoxon rank-sum test was performed at a 5% significance level on the percent normalized change measures in the overground gait performance. Partial least squares regression (PLSR) analysis was performed on the quantitative gait parameters as response variables to the mean lobular electric field strength as the predictors. Clinical assessments were performed with the Ten-Meter walk test (TMWT), Timed Up & Go (TUG), and the Berg Balance Scale based on minimal clinically important differences (MCID). Results The ctDCS montage specific effect was found significant using a two-sided Wilcoxon rank-sum test at a 5% significance level for 'Step Time Affected Leg' (p = 0.0257) and '%Stance Time Unaffected Leg' (p = 0.0376). The changes in the quantitative gait parameters were found to be correlated to the mean electric field strength in the lobules based on PLSR analysis (R2 statistic = 0.6574). Here, the mean electric field strength at the cerebellar lobules, Vermis VIIIb, Ipsi-lesional IX, Vermis IX, Ipsi-lesional X, had the most loading and were positively related to the 'Step Time Affected Leg' and '%Stance Time Unaffected Leg,' and negatively related to the '%Swing Time Unaffected Leg,' '%Single Support Time Affected Leg.' Clinical assessments found similar improvement in the TMWT (MCID: 0.10 m/s), TUG (MCID: 8 s), and BBS score (MCID: 12.5 points) for both the ctDCS montages. Conclusion Our feasibility study found an association between the lobular mean electric field strength and the changes in the quantitative gait parameters following a single ctDCS session in chronic stroke. Both the ctDCS montages improved the clinical outcome measures that should be investigated with a larger sample size for clinical validation. Trial registration: Being retrospectively registered.

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“…Jalali et al (2018) found no evidence for changes in (excitatory) glutamate and (inhibitory) GABA concentrations in the right cerebellar hemisphere following 25 minutes of anodal tDCS at an intensity of 2 mA over the right cerebellum. Also, a study by Moussa-Tooks et al (2020) did not yield consistent effects on neurotransmitter concentrations to 1.5 mA anodal or sham tDCS over the left cerebellar hemisphere for 20 minutes.…”

Section: Cerebellar Transcranial Direct Current Stimulationmentioning

confidence: 92%

“…Overall, this suggests that while cerebellar tDCS is able to modulate cerebello-cortical pathways, the direction of the physiological effect is difficult to anticipate. To further address this issue, magnetic resonance spectroscopy (MRS) has been used to investigate the effects of tDCS on neurotransmitter concentrations in the cerebellum (Jalali et al 2018;Moussa-Tooks et al 2020). Jalali et al (2018) found no evidence for changes in (excitatory) glutamate and (inhibitory) GABA concentrations in the right cerebellar hemisphere following 25 minutes of anodal tDCS at an intensity of 2 mA over the right cerebellum.…”

Section: Cerebellar Transcranial Direct Current Stimulationmentioning

confidence: 99%

Non-invasive Brain Stimulation of the Cerebellum in Emotion

Klaus

Schutter

2022

The Emotional Cerebellum

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Transcranial magnetic and direct current stimulation are non-invasive brain stimulation techniques that are used to investigate cerebellar functions in healthy and clinical populations. These approaches allow transient modulation of neural excitability of the human cerebellar cortex to directly examine phenomenological, behavioral, and physiological aspects of motivation and emotion. While cerebellar neurostimulation in the field of social and affective neuroscience is still in its initial phase, empirical evidence confirms the direct involvement of the cerebellum in motivation and emotion. Non-invasive stimulation of the cerebellum provides a unique experimental approach to study the relation between the cerebellum and emotions in humans.

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Cerebellar tDCS consistency and metabolite changes: A recommendation to decrease barriers to replicability

Cited by 6 publications

References 13 publications

No Impact of Cerebellar Anodal Transcranial Direct Current Stimulation at Three Different Timings on Motor Learning in a Sequential Finger-Tapping Task

No Impact of Cerebellar Anodal Transcranial Direct Current Stimulation at Three Different Timings on Motor Learning in a Sequential Finger-Tapping Task

Investigating the feasibility of cerebellar transcranial direct current stimulation to facilitate post-stroke overground gait performance in chronic stroke: a partial least-squares regression approach

Non-invasive Brain Stimulation of the Cerebellum in Emotion

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