Cerebellar Purkyn? cell responses to inputs from sensorimotor cortex

Allen, G. I.; Azzena, Gian Battista; Ohno, Tadao

doi:10.1007/bf00238315

Cited by 27 publications

(16 citation statements)

References 32 publications

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“…First, within the rostral dorsal accessory olive (the site of relay for climbing fiber paths terminating in the medial C1 zone), descending and ascending projections overlap heavily (Berkley and Worden, 1978;Bull et al, 1990). We found that complex spikes of single Purkinje cells could be evoked by both SR and CP stimulation, providing unequivocal evidence that descending and ascending paths can converge on the same olivary neurons supplying climbing fibers to the relevant region of cortex, as reported previously (Provini et al, 1968;Miller et al, 1969;Leicht et al, 1973;Allen et al, 1974).…”

Section: Methodological Considerationssupporting

confidence: 84%

“…Llinas and Sasaki, 1989) and/or our use of submaximal stimulus intensities (typically, twice the threshold for evoking a detectable cortical response) (cf. Allen et al, 1974). Note also that for the paired-pulse test, facilitations were evident at longer stimulus intervals.…”

Section: Evidence That Sr and Cp Stimulation Activate A Similar Populmentioning

confidence: 87%

“…Given the size and distribution of the evoked field potentials, the results also suggest that COCPs provide a potent excitatory input to climbing fibers in the behaving animal. Activation of such paths has only previously been demonstrated in anesthetized preparations (Miller et al, 1969;Allen et al, 1974;Andersson and Nyquist, 1983;Baker et al, 2001). …”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the test response was on average 71% smaller at an interstimulus interval of 20 msec (cf. Allen et al, 1974).…”

Section: Methodological Considerationsmentioning

confidence: 99%

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Changes in Excitability of Ascending and Descending Inputs to Cerebellar Climbing Fibers during Locomotion

Pardoe¹,

Edgley²,

Drew³

et al. 2004

J. Neurosci.

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The inferior olive climbing fiber projection plays a central role in all major theories of cerebellar function. Therefore, mechanisms that control the ability of climbing fibers to forward information to the cerebellum are of considerable interest. We examined changes in transmission in cerebro-olivocerebellar pathways (COCPs) and spino-olivocerebellar pathways (SOCPs) during locomotion in awake cats (n ϭ 4) using low-intensity electrical stimuli delivered to the contralateral cerebral peduncle or the ipsilateral superficial radial nerve to set up volleys in COCPs and SOCPs, respectively. The responses were recorded as evoked extracellular climbing fiber field potentials within the C1 or C3 zones in the paravermal cerebellar cortex (lobule Va-Vc). At most C1 and C3 zone sites, the largest COCP responses occurred during the stance phase, and the smallest responses occurred during the swing phase of the ipsilateral forelimb step cycle. In marked contrast, SOCP responses recorded at the same sites were usually largest during the swing phase and smallest during the stance phase. Because substantial climbing fiber responses could be evoked in all phases of the step cycle, the results imply that olivary neurons remain excitable throughout, and that the differences between SOCPs and COCPs in their pattern of step-related modulation are unlikely to have arisen solely through inhibition at the level of the inferior olive (e.g., by activity in the inhibitory cerebellar nucleo-olivary pathway). The different patterns of modulation also suggest that climbing fiber signals conveyed by COCPs and SOCPs are likely to affect information processing within the cerebellar cortical C1 and C3 zones at different times during locomotion.

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Section: Methodological Considerationssupporting

confidence: 84%

Section: Evidence That Sr and Cp Stimulation Activate A Similar Populmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

“…In contrast, the test response was on average 71% smaller at an interstimulus interval of 20 msec (cf. Allen et al, 1974).…”

Section: Methodological Considerationsmentioning

confidence: 99%

See 2 more Smart Citations

Changes in Excitability of Ascending and Descending Inputs to Cerebellar Climbing Fibers during Locomotion

Pardoe¹,

Edgley²,

Drew³

et al. 2004

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Artifacts of iontophoretic current, pH, local anaesthesia, or failure to release drug were controlled, as previously described . Climbing and mossy fibres were activated by triple shocks (500 Hz) to the limbs, snout, or cerebral cortex (Allen, Azzena & Ohuo, 1974). 'Off beam' surface stimulation (single shock) was used to activate inhibitory basket and stellate cell inputs (Eccles, Ito & Szentagothai, 1967 (Freedman, Hoffer & Woodward, 1975 Results Mossy fibre activation is known to result in simple spike excitation of the Purkinje cell, with a latency of 5 to 10 ms (Allen et al, 1974).…”

mentioning

confidence: 99%

Noradrenaline Modulation of the Responses of the Cerebellar Purkinje Cell to Afferent Synaptic Activity

Freedman

Hoffer

Puro

et al. 1976

British J Pharmacology

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Noradrenaline, applied by microiontophoresis to rat cerebellar Purkinje neurones, selectively depressed spontaneous neuronal discharge. Simple spike and complex spike excitations, evoked by stimulation of the mossy and climbing fibres, were relatively preserved during the inhibition of spontaneous activity, and the number of full-sized action potentials in the complex spike increased. Inhibition mediated by the basket and stellate cells was augmented. Thus, relative to the change in spontaneous activity, noradrenaline increased the responsiveness of the Purkinje cell to afferent input.

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Transient cerebrocerebellar projections in kittens: Postnatal development and topography

Tolbert

Panneton

1983

J of Comparative Neurology

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Orthograde and retrograde labeling techniques were used to study the ontogenesis of transient cerebrocerebellar projections in kittens. Tritiated amino-acid or horseradish peroxidase injections were made into the coronal gyrus of the primary somatosensory cortex of kittens 1-70 postnatal days old. Orthogradely labeled axons were observed bilaterally in the superior and inferior cerebellar peduncles in kittens between 6 and 49 postnatal days of age. Most cerebrocerebellar axons labeled on the ipsilateral side arise from the pyramidal tract as it courses through the pontine nuclei. These axons descend through the pontine tegmentum as a diffusely organized corticotegmental tract and enter the ipsilateral superior cerebellar peduncle. Fewer cerebrocerebellar axons leave the pyramidal tract caudal to the pontine nuclei and project into the contralateral superior cerebellar peduncle. Cerebrocerebellar projections through the superior cerebellar peduncles terminate primarily in the cerebellar nuclei, where they are localized in the interpositus nuclei and in immediately adjacent areas of the dentate and fastigial nuclei. More caudally, labeled axons exit from the pyramidal tract and take a superficial route around the ventrolateral brainstem into the inferior cerebellar peduncles bilaterally. These projections are more numerous contralaterally and are directed primarily to the internal granule cell layer of the posterolateral folia of the anterior lobe, the posteromedial simplex lobule, and the dorsal paramedian lobule. Horseradish peroxidase injections were made into the cerebellar posterior lobe and deep nuclei and the results from these cases showed that the cerebrocerebellar pathway originates from pyramidal neurons in layer V primarily in the coronal, the precoronal, and the anterior and posterior sigmoid gyri on both sides. In these gyri, many of the HRP-positive neurons were found in clusters of two to five neurons, aligned in anterior-posterior strips. The results from all experiments provide evidence about the ontogeny of cerebrocerebellar projections. Projections through the superior cerebellar peduncles generally develop at 6-8 postnatal days of age, whereas projections through the inferior cerebellar peduncles first are seen at 8-10 days postnatally. Cerebrocerebellar projections reach their maximum development in the second postnatal week but sharply decrease in density during the third postnatal week. No cerebrocerebellar projections were observed after the seventh postnatal week of development. Possible functional implications for this transient projection are discussed.

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Cerebellar Purkyn? cell responses to inputs from sensorimotor cortex

Cited by 27 publications

References 32 publications

Changes in Excitability of Ascending and Descending Inputs to Cerebellar Climbing Fibers during Locomotion

Changes in Excitability of Ascending and Descending Inputs to Cerebellar Climbing Fibers during Locomotion

Noradrenaline Modulation of the Responses of the Cerebellar Purkinje Cell to Afferent Synaptic Activity

Transient cerebrocerebellar projections in kittens: Postnatal development and topography

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