Cerebellar Mutism Syndrome After Posterior Fossa Tumor Surgery in Children—A Retrospective Single-Center Study

Schmidt, Stephanie; Kovács, Edina; Usta, Diren; Behnisch, Rouven; Sahm, Felix; Haux, Daniel; Witt, Olaf; Milde, Till; Unterberg, Andreas; Damaty, Ahmed El

doi:10.1016/j.wneu.2023.02.117

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…And from these, many theories to explain the postoperative paucity of speech have been postulated including: bilateral destruction or edema of the cerebellar nuclei [40], vasospasm, post-operative meningitis, unrecognized hydrocephalus, and psychiatric origin [5]. Risk factors most commonly associated with development of CMS include midline tumor location [14], surgical approach [3,25,[41][42][43][44][45][46], brain stem invasion or compression[8, 14, 47-49], tumor size [3,26,38], diagnosis of medulloblastoma [3,21,50,[50][51][52][53] and speci c tumor subtype [20,50], younger age at diagnosis [22,23] and preoperative language impairment [39], lower volume centers [22], male gender [23,54], left handedness [38,55]. Other authors failed to nd an association between age [22], ventricular size [19,22], extent of resection[8, 19,22], tumor size [22], handedness 35 , surgical approach [41], location in the cerebellar hemisphere[8], ultrasonic aspirator use [19], low volume center [19] nor second surgery [56].…”

Section: Discussionmentioning

confidence: 99%

National multicentered retrospective review of clinical and intraoperative factors associated with the development of cerebellar mutism after pediatric posterior fossa tumor resection

Kameda-Smith,

Ragulojan,

Elliott

et al. 2024

Childs Nerv Syst

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BackgroundCerebellar mutism (CM) is characterized by a signi cant loss of speech in children following posterior fossa (PF) surgery. The biological origin of CM remains unclear and is the subject of ongoing debate.Signi cant recovery from CM is less likely than previously described despite rigorous multidisciplinary neuro-rehabilitational efforts. MethodsA national multi-centered retrospective review of all children undergoing PF resection in 4 midsized Canadian academic pediatric institutions was undertaken. Patient, tumor, and surgical factors associated with the post-operative development of CM were reviewed. Retrospective identi cation of PF surgery patients including those developing and those that did not (internal control). ResultsThe study identi ed 258 patients across the 4 centers between 2010-2020 (mean age 6.73 years; 42.2 female). Overall, CM was experienced in 19.5% of patients (N = 50). Amongst children who developed CM histopathology included medulloblastoma (35.7%), pilocytic astrocytoma (32.6%), and ependymoma (17.1%). Intraoperative impression of adherence to the oor of the 4th ventricle was positive in 36.8%.Intraoperative abrupt changes in blood pressure and/or heart rate were identi ed in 19.4% and 17.8% of cases. The clinical resolution of CM was rated to be complete, signi cant resolution, slight improvement, no improvement, and deterioration in 56.0%, 8.0%, 20.0%, 14.0%, 2.0%, respectively. In the cohort of children who experienced post-operative CM as compared to their no-CM counterpart, proportionally more tumors were felt to be adherent to the oor of the 4th ventricle (56.0% vs 49.5%), intraoperative extent of resection was a GTR (74% vs 68.8%), and changes in heart rate were noted (≥ 20% from baseline) (26.0% vs 15.9%). However, a logistic regression for experiencing CM identi ed only intraoperative impression of adherence to the oor of the 4th ventricle (OR 2.32, p = 0.011), abrupt changes in intraoperative HR (> 20% from baseline) (OR 2.34, p = 0.028), and medulloblastoma histology (OR 3.77, p = 0.001) to signi cantly associated with development of post-operative CM. ConclusionAs a devastating surgical complication, identifying and understanding the biological origin of CM is the rst step to complication avoidance. Maximal safe resection irrespective of intraoperative pathology remains the strategy to minimize the devastating post-operative development of CM.

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Section: Discussionmentioning

confidence: 99%

National multicentered retrospective review of clinical and intraoperative factors associated with the development of cerebellar mutism after pediatric posterior fossa tumor resection

Kameda-Smith,

Ragulojan,

Elliott

et al. 2024

Childs Nerv Syst

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Clinical cerebellar neuroscience: ataxias — cognitive and affective symptoms in focal cerebellar lesions

Erdlenbruch,

Timmann,

Thieme

2024

Current Opinion in Behavioral Sciences

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National multicentered retrospective review of clinical and intraoperative factors associated with the development of cerebellar mutism after pediatric posterior fossa tumor resection

Kameda-Smith,

Ralugojan,

Elliott

et al. 2023

Preprint

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Background Cerebellar mutism (CM) is characterized by a significant loss of speech in children following posterior fossa (PF) surgery. The biological origin of CM remains unclear and is the subject of ongoing debate. Significant recovery from CM is less likely than previously described despite rigorous multidisciplinary neuro-rehabilitational efforts. Methods A national multi-centered retrospective review of all children undergoing PF resection in 4 midsized Canadian academic pediatric institutions was undertaken. Patient, tumor, and surgical factors associated with the post-operative development of CM were reviewed. Retrospective identification of PF surgery patients including those developing and those that did not (internal control). Results The study identified 258 patients across the 4 centers between 2010–2020 (mean age 6.73 years; 42.2 female). Overall, CM was experienced in 19.5% of patients (N = 50). Amongst children who developed CM histopathology included medulloblastoma (35.7%), pilocytic astrocytoma (32.6%), and ependymoma (17.1%). Intraoperative impression of adherence to the floor of the 4th ventricle was positive in 36.8%. Intraoperative abrupt changes in blood pressure and/or heart rate were identified in 19.4% and 17.8% of cases. The clinical resolution of CM was rated to be complete, significant resolution, slight improvement, no improvement, and deterioration in 56.0%, 8.0%, 20.0%, 14.0%, 2.0%, respectively. In the cohort of children who experienced post-operative CM as compared to their no-CM counterpart, proportionally more tumors were felt to be adherent to the floor of the 4th ventricle (56.0% vs 49.5%), intraoperative extent of resection was a GTR (74% vs 68.8%), and changes in heart rate were noted (≥ 20% from baseline) (26.0% vs 15.9%). However, a logistic regression for experiencing CM identified only intraoperative impression of adherence to the floor of the 4th ventricle (OR 2.32, p = 0.011), abrupt changes in intraoperative HR (> 20% from baseline) (OR 2.34, p = 0.028), and medulloblastoma histology (OR 3.77, p = 0.001) to significantly associated with development of post-operative CM. Conclusion As a devastating surgical complication, identifying and understanding the biological origin of CM is the first step to complication avoidance. Maximal safe resection irrespective of intraoperative pathology remains the strategy to minimize the devastating post-operative development of CM.

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Cerebellar Mutism Syndrome After Posterior Fossa Tumor Surgery in Children—A Retrospective Single-Center Study

Cited by 3 publications

References 24 publications

National multicentered retrospective review of clinical and intraoperative factors associated with the development of cerebellar mutism after pediatric posterior fossa tumor resection

National multicentered retrospective review of clinical and intraoperative factors associated with the development of cerebellar mutism after pediatric posterior fossa tumor resection

Clinical cerebellar neuroscience: ataxias — cognitive and affective symptoms in focal cerebellar lesions

National multicentered retrospective review of clinical and intraoperative factors associated with the development of cerebellar mutism after pediatric posterior fossa tumor resection

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