Cerebellar microstructural abnormalities in bipolar depression and unipolar depression: A diffusion kurtosis and perfusion imaging study

Zhao, Lianping; Wang, Ying; Jia, Yanbin; Zhong, Shuming; Sun, Yipeng; Zhou, Zhifeng; Zhang, Zhongping; Huang, Li

doi:10.1016/j.jad.2016.01.042

Cited by 57 publications

(68 citation statements)

References 52 publications

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“…Simultaneous cerebellar and amygdala reduction in MDD was also reported in prior gray matter density studies (Lee et al 2011; Peng et al 2011). Recent studies have shown that the cerebellum plays a role in emotion regulation and cognition (Baldacara et al 2008; Bugalho et al 2006; Phillips et al 2015), and also have implicated the cerebellum in MDD based on findings of altered structure (Yucel et al 2013; Zhao et al 2016) and function (Liu et al 2012; Ma et al 2013). …”

Section: Discussionmentioning

confidence: 99%

Co-altered functional networks and brain structure in unmedicated patients with bipolar and major depressive disorders

Sui

et al. 2017

Brain Struct Funct

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Bipolar disorder (BD) and major depressive disorder (MDD) share similar clinical characteristics that often obscure the diagnostic distinctions between these conditions. Both functional and structural brain abnormalities have been reported in these two disorders. However, the direct link between altered functioning and structure in these two diseases is unknown. To elucidate this relationship, we conducted a multimodal fusion analysis on the functional network connectivity (FNC) and gray matter density (GMD) from MRI data from 13 BD, 40 MDD, and 33 matched healthy controls (HC). A data-driven fusion method called mCCA+jICA was used to identify the co-altered FNC and GMD components. We found reduced GMD in the parietal and occipital cortices related to lower FNC in a sensory-motor network as well as stronger interconnection in frontal regions in BD compared to HC. Meanwhile, the MDD group exhibited GMD deficits in the amygdala and cerebellum. Among preliminary classifiers trained using features generated from these group discriminative components, the overall accuracy with resampling and cross-validation reached 91.3% for 3 groups and 99.5% for BD versus MDD. Our findings suggest that both overlapping and unique functional and structural deficits exist in BD and MDD, and the abnormalities may be utilized as potential diagnostic biomarkers.

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Section: Discussionmentioning

confidence: 99%

Co-altered functional networks and brain structure in unmedicated patients with bipolar and major depressive disorders

Sui

et al. 2017

Brain Struct Funct

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“…Some recent studies 34 35 36 conducting functional investigations of BD or UD have also reported impairment of perfusion and have demonstrated that changes in cerebral blood flow (CBF) might play a role in the development of the two disorders. Three dimensional arterial spin labeling (3D ASL) is a relatively novel developed MR perfusion technique that can noninvasively assess CBF by using arterial blood water as an endogenous freely diffusible tracer.…”

Section: Introductionmentioning

confidence: 99%

Microstructural Abnormalities of Basal Ganglia and Thalamus in Bipolar and Unipolar Disorders: A Diffusion Kurtosis and Perfusion Imaging Study

Zhao

Wang

Jia

et al. 2017

Psychiatry Investig

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ObjectiveBipolar disorder (BD) is often misdiagnosed as unipolar depression (UD), leading to mistreatment and poor clinical outcomes. However, little is known about the similarities and differences in subcorticalgray matter regions between BD and UD.MethodsThirty-five BD patients, 30 UD patients and 40 healthy controls underwent diffusional kurtosis imaging (DKI) and three dimensional arterial spin labeling (3D ASL). The parameters including mean kurtosis (MK), axial kurtosis (Ka), radial kurtosis (Kr), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), radial diffusivity (Dr) and cerebral blood flow (CBF) were measured by using regions-of-interest analysis in the caudate, putamen and thalamus of the subcortical gray matter regions.ResultsUD exhibited differences from controls for DKI measures and CBF in the left putamen and caudate. BD showed differences from controls for DKI measures in the left caudate. Additionally, BD showed lower Ka in right putamen, higher MD in right caudate compared with UD. Receiver operating characteristic analysis revealed the Kr of left caudate had the highest predictive power for distinguishing UD from controls.ConclusionThe two disorders may have overlaps in microstructural abnormality in basal ganglia. The change of caudate may serve as a potential biomarker for UD.

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“…Cognitive impairment is consistently observed in patients with depressive disorder and obstructs rehabilitation. Nonetheless, a consistent biomarker during recovery may be helpful in the differential treatment and management of these disorders …”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, a consistent biomarker during recovery may be helpful in the differential treatment and management of these disorders. 54 We also combined the area density fraction of axons and dendrites from immunohistological data as a rough histological estimate of neurite density (H ν ). H ν was found to be significantly reduced in both dHP and vHP, supporting the dMRI-based findings in the HP.…”

Section: Figurementioning

confidence: 99%

Neurite atrophy in dorsal hippocampus of rat indicates incomplete recovery of chronic mild stress induced depression

et al. 2019

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Depression is a leading cause of disability worldwide, and it can often ensue after a chronic mild stress (CMS) exposure. Despite intensive preclinical and clinical research, an objective test to diagnose depression is still not available, causing suboptimal diagnosis and treatment. Recently, the neuronal tracing technique and stereology showed persistent microstructural alterations in the stress‐sensitive brain regions, such as dendritic atrophy in the hippocampus (HP) and prefrontal cortex, (PFC) and hypertrophy in the amygdala (AM). These brain regions also showed consistent gliosis in cadaver brains of patients with depressive disorders as well as in the animal model of depression. Clinically feasible methods to probe these microstructural alterations could be useful in treatment planning and intervention. The present study employed ex vivo diffusion MRI (dMRI) and immunohistochemistry to identify microstructural alterations in stress‐sensitive brain regions of CMS‐induced anhedonic rats after eight weeks of spontaneous recovery in comparison with age‐matched controls. The investigation employs dMRI‐based neurite density model parameters (ν, Deff, and DL), traditional diffusion kurtosis imaging parameters (mean kurtosis, axial kurtosis, and radial kurtosis), kurtosis tensor parameters (mean kurtosis tensor, WL, and WT), and diffusion tensor parameters (fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity). The neurite density (ν) parameter has shown a significant reduction in dorsal HP in comparison with the control, while immunohistochemistry showed a significant reduction in histological neurite density (Hν) in dorsal HP, ventral HP, and AM. Hν also showed significant correlation with ν, which strengthens the reliability of ν and provides a plausible underpinning of the diffusion signal. However, the correlation was not significant when evaluated in the anhedonic group alone. These stress‐recovery findings are opposite to the changes observed just after the CMS exposure paradigm in our recent in vivo study. The present study revealed long‐term effects of CMS exposure, which may be due to incomplete microstructural normalization or long‐lasting microstructural alterations in dHP.

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Cerebellar microstructural abnormalities in bipolar depression and unipolar depression: A diffusion kurtosis and perfusion imaging study

Cited by 57 publications

References 52 publications

Co-altered functional networks and brain structure in unmedicated patients with bipolar and major depressive disorders

Co-altered functional networks and brain structure in unmedicated patients with bipolar and major depressive disorders

Microstructural Abnormalities of Basal Ganglia and Thalamus in Bipolar and Unipolar Disorders: A Diffusion Kurtosis and Perfusion Imaging Study

Neurite atrophy in dorsal hippocampus of rat indicates incomplete recovery of chronic mild stress induced depression

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