“Cerebellar lesions after low-grade tumor resection can induce memory impairment in children, similar to that observed in patients with frontal lesions”

Starowicz-Filip, Anna; Chrobak, Adrian Andrzej; Kwiatkowski, Stanisław; Milczarek, Olga; Rajtar-Zembaty, Anna

doi:10.1080/09297049.2019.1657391

Cited by 9 publications

(15 citation statements)

References 54 publications

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“…The recalling difficulties are also characterized by cerebellar laterality, as in our research, they concern only patients with right-sided cerebellar hemispheric lesions. In general, our research confirms the conclusions reached in previous single studies about the frontal-like nature of memory disorders accompanying patients with cerebellar damage (Koziol et al, 2014;Starowicz-Filip et al, 2020). However, contrarily to present findings, the frontal-like profile of cerebellar memory impairments obtained for pediatric patients in Starowicz-Filip et al's (2020) was irrespective of the cerebellar lesion side.…”

Section: Discussionsupporting

confidence: 92%

“…The results obtained by participants in the memory (memory retrieval and memory recognition) and fluency (perseverations and intrusions) domains have been analyzed in more detail to establish whether the cognitive profile of patients with cerebellar lesions can be characterized as frontal-like, as it has been demonstrated in the previous research (Starowicz-Filip et al, 2020). Moreover, because right cerebellar lesions are linked with language impairments, we also checked which components of the ACE III language domain are mostly attenuated due to cerebellar damage.…”

Section: Resultsmentioning

confidence: 97%

“…In our study, the patients with lesions localized in the left cerebellar hemisphere showed difficulties in copying geometric shapes, Mobius band, and cube or in the clock task. Previous research on adults (Riva and Giorgi, 2000;Molinari et al, 2004;Baillieux et al, 2010;Starowicz-Filip et al, 2020) and pediatric samples (Starowicz-Filip et al, 2017) have also yielded such selective attention and visuospatial impairments against the background of preserved language functions. These visuospatial impairments appeared particularly evident in the tasks of processing complex figures mentally, such as the mental rotation task and manipulation of tridimensional stimuli (Molinari et al, 2004) which are more demanding than straightforward redrawing of visually presented objects.…”

Section: Discussionmentioning

confidence: 94%

“…There is also a growing body of research which did not confirm the cerebellar crossed laterality effect (Levisohn et al, 2000;Beebe et al, 2005). Moreover, although single scientific reports confirmed the clear effect of cerebellar functional lateralization of left cerebellar hemisphere, and its connection with attention and visuospatial dysfunctions, the cognitive functioning of patients with cerebellar right-sided lesions shows the tendency to more global decline, going beyond the selective damage to linguistic functions (Baillieux et al, 2009;Daszkiewicz et al, 2009;Starowicz-Filip et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Cerebellar Functional Lateralization From the Perspective of Clinical Neuropsychology

et al. 2021

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Objective: The cerebellar functional laterality, with its right hemisphere predominantly involved in verbal performance and the left one engaged in visuospatial processes, has strong empirical support. However, the clinical observation and single research results show that the damage to the right cerebellar hemisphere may cause extralinguistic and more global cognitive decline. The aim of our research was to assess the pattern of cognitive functioning, depending on the cerebellar lesion side, with particular emphasis on the damage to the right cerebellar hemisphere.Method: The study sample consisted of 31 patients with focal cerebellar lesions and 31 controls, free of organic brain damage. The Addenbrooke’s Cognitive Examination ACE III and the Trail Making Test TMT were used to assess patients’ cognitive functioning.Results: Left-sided cerebellar lesion patients scored lower than controls in attention and visuospatial domain, but not in language, fluency, and memory functions. Participants with right-sided cerebellar lesion demonstrated a general deficit of cognitive functioning, with impairments not only in language and verbal fluency subscales but also in all ACE III domains, including memory, attention, and visuospatial functions. The TMT results proved that cerebellar damage is associated with executive function impairment, regardless of the lesion side.Conclusion: The cognitive profiles of patients with cerebellum lesions differ with regard to the lesion side. Left-sided cerebellar lesions are associated with selective visuospatial and attention impairments, whereas the right-sided ones may result in a more global cognitive decline, which is likely secondary to language deficiencies, associated with this lateral cerebellar injury.

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Section: Discussionsupporting

confidence: 92%

Section: Resultsmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Cerebellar Functional Lateralization From the Perspective of Clinical Neuropsychology

et al. 2021

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“…41 On the other hand, the presence of hydrocephalus seems to be associated with deficits in the development of memory functions also in children without intellectual disability and independently of the underlying etiology. 42 Moreover, specific cerebellar components, such as the right cerebellar hemisphere 43 Our results demonstrated that performances in visual attention were related to the number of fibers of the left PPC tract. The current hypothesis is that there are two major visual perceptual systems: the parietal-occipital circuit, which gives information about the location of the object, and the temporal-occipital one, which char-acterizes it.…”

Section: Correlation With Cerebellar Tracts According To Dti Tractogrmentioning

confidence: 57%

Possible association between the integrity of cerebellar pathways and neurocognitive performance in children with posterior fossa tumors

Liguoro

Passone

Zilli

et al. 2020

Pediatric Blood & Cancer

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Background Cerebellar tumor survivors often exhibit neuropsychological deficits that could be related to alterations in cerebro‐cerebellar networks. This is a pilot study designed to understand if diffusion tensor imaging (DTI)‐based tractography is able to identify possible correlations between cerebellar white matter structure and cognitive outcome in children on long‐term follow‐up for posterior fossa (PF) tumors who were thoroughly assessed for neuropsychological functioning. Methods DTI‐based tractography was performed in pediatric patients with PF tumors. Fractional anisotropy (FA) and volumetric measurements of spinocerebellar, dentorubrothalamocortical and corticopontocerebellar tracts were analyzed. Cognitive and neuropsychological functioning was assessed by the Wechsler Intelligence Scale for Children–IV Edition (WISC‐IV) and the Developmental Neuropsychological Assessment (NEPSY II). The associations between Full‐Scale Intelligence Quotient (FSIQ), NEPSY‐II scores, and fiber tracts were tested by the Spearman rank correlation coefficient. Results Seven patients (median age at diagnosis five years, range, 3‐13) treated for medulloblastoma (2/7; 29%) and pilocytic astrocytoma (5/7; 71%) were retrospectively evaluated. All children had complete surgery. The median FSIQ was 84 (range, 67‐93). Patients presented with several deficits on many NEPSY‐II tasks; in particular, memory was impaired in nearly half of them. FSIQ and neurocognitive tasks significantly correlated with specific corticopontocerebellar tracts. Conclusion Children on follow‐up for PF tumor showed scattered cognitive impairments, including deficits in long‐term and immediate memory. Tractography allowed us to describe a possible association between the integrity of cerebellar pathways and neurocognitive performance, suggesting that the myelinization of these fibers may represent an indicator for the development of long‐term cognitive sequelae.

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Language outcomes in children who underwent surgery for the removal of a posterior fossa tumor: A systematic review

Svaldi,

Ntemou,

Jonkers

et al. 2024

European Journal of Paediatric Neurology

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“Cerebellar lesions after low-grade tumor resection can induce memory impairment in children, similar to that observed in patients with frontal lesions”

Cited by 9 publications

References 54 publications

Cerebellar Functional Lateralization From the Perspective of Clinical Neuropsychology

Cerebellar Functional Lateralization From the Perspective of Clinical Neuropsychology

Possible association between the integrity of cerebellar pathways and neurocognitive performance in children with posterior fossa tumors

Language outcomes in children who underwent surgery for the removal of a posterior fossa tumor: A systematic review

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