Cerebellar induced aphasia: case report of cerebellar induced prefrontal aphasic language phenomena supported by SPECT findings

Mariën, Peter; Saerens, J.; Nanhoe, R.; Moens, Ellen; Nagels, Guy; Pickut, Barbara A.; Dierckx, Rudi; Deyn, Peter Paul De

doi:10.1016/s0022-510x(96)00059-7

Cited by 118 publications

(102 citation statements)

References 61 publications

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“…Finally, Gasparini et al (1999) tested a fourth patient with a superior-lateral right cerebellar infarct who also manifested some grammatical difficulties in his Italian speech, along with a slightly reduced verbal immediate recall, slowed speech, and severe word-finding difficulties. Like the patient described by Mariën et al (1996Mariën et al ( ,2000, this patient was also impaired on a test of sentence comprehension (8 correct out of 17). While these cases provided the most extensive testing of grammatical morphology, other reports of cerebellar patients focusing on other aspects of language have also mentioned grammatical difficulties (Fabbro et al, 2000;Riva & Giorgi, 2000;Mewasingh et al, 2003).…”

Section: Introductionmentioning

confidence: 51%

“…In addition to dysarthric speech and slightly reduced verbal fluency, the patient had a tendency to omit free-standing grammatical morphemes (e.g., auxiliaries) and clitics in his spontaneous speech and often used the infinitive form of a verb rather than conjugating it. Mariën et al (1996Mariën et al ( ,2000 described a second cerebellar patient with abnormal grammatical morphology. This Dutch-speaking patient had suffered a lesion to the right cerebellar hemisphere, with additional minor damage to the basal ganglia.…”

Section: Introductionmentioning

confidence: 99%

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The Cerebellum and English Grammatical Morphology: Evidence from Production, Comprehension, and Grammaticality Judgments

Justus

2004

Journal of Cognitive Neuroscience

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Three neuropsychological experiments on a group of 16 cerebellar patients and 16 age-and education-matched controls investigated the effects of damage to the cerebellum on English grammatical morphology across production, comprehension, and grammaticality judgment tasks. In Experiment 1, participants described a series of pictures previously used in studies of cortical aphasic patients. The cerebellar patients did not differ significantly from the controls in the total number of words produced or in the proportion of closed-class words. They did differ to a marginally significant extent in the production of required articles. In Experiment 2, participants identified the agent in a series of aurally presented sentences in which three agency cues (subject-verb agreement, word order, and noun animacy) were manipulated. The cerebellar patients were less affected than the controls were by the manipulation of subject-verb agreement to a marginally significant extent. In Experiment 3, participants performed a grammaticality judgment task on a series of aurally presented sentences. The cerebellar patients were significantly less able to discriminate grammatical and ungrammatical sentences than the controls were, particularly when the error was of subject-verb agreement as opposed to word order. The results suggest that damage to the cerebellum can result in subtle impairments in the use of grammatical morphology, and are discussed in light of hypothesized roles for the cerebellum in language.

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Section: Introductionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

The Cerebellum and English Grammatical Morphology: Evidence from Production, Comprehension, and Grammaticality Judgments

Justus

2004

Journal of Cognitive Neuroscience

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“…Secondly, it is generally accepted that the left inferior frontal gyrus of the language dominant hemisphere is crucially implicated in (expressive) syntax processing. Lesion studies have also shown that damage to the adjacent neural structures such as the dominant frontal operculum (Alexander, Naesser, & Palumbo, 1990), the insula (Dronkers, 1996) and the precentral gyrus (Miceli et al, 1983) may lead to agrammatism and a number of recent case reports have demonstrated that focal damage to the right cerebellum, functionally linked with the prefrontal language areas, may cause expressive and receptive agrammatism as well (Silveri, Leggio, & Molinari, 1994;Mariën, Saerens, Nanhoe, Moens, Nagels, et al, 1996;Fabbro, Skrap, & Aglioti, 2000;Mariën, Engelborghs, Fabbro, & De Deyn, 2001). A detailed literature survey, however, did not reveal one single instance of agrammatism following a causative lesion in the upper BA6 of the language dominant hemisphere.…”

Section: Discussionmentioning

confidence: 99%

Grammar disruption in a patient with Neuro-Sweet syndrome

et al. 2012

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This paper for the first time reports detailed neurolinguistic findings in a patient with NeuroSweet syndrome. In this patient the presenting symptoms of central nervous system involvement primarily consisted of a selective grammar deficit restricted to spontaneous speech. On MRI a left prefrontal ischemic stroke (superior part BA 6) and two small subcortical left parietal infarctions were found. Neurolinguistic analyses, however, did not reveal a profile consistent with any observations of agrammatism caused by structural damage to the language areas critically involved in grammatical processing. It is hypothesized that selectively distorted grammar might reflect disruption of the frontosubcortical network involved in language processing. Prefrontal neurobehavioural abnormalities associated with functional disruption of the inferior medial frontal regions as demonstrated by SPECT, additionally suggest that agrammatic symptoms may be linked to a higher-level cognitive disorder following encephalopathic central nervous system involvement.

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“…It cannot be excluded, however, that more subtle language deficits may be revealed in a larger group of children with chronic cerebellar lesions and in more challenging tasks. Specific problems in grammar function, verbal working memory, temporal aspects of both speech production and perception have been shown in adult cerebellar patients (Ackermann et al 2004;Desmond et al 1997;Gasparini et al 1999;Justus 2004;Marien et al 1996Marien et al , 2000Zettin et al 1997).…”

Section: Aphasiamentioning

confidence: 99%

Children and Adolescents With Chronic Cerebellar Lesions Show No Clinically Relevant Signs of Aphasia or Neglect

Richter

Schoch²,

Kaiser³

et al. 2005

Journal of Neurophysiology

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. Children and adolescents with chronic cerebellar lesions show no clinically relevant signs of aphasia or neglect. J Neurophysiol 94: 4108 -4120, 2005. First published July 20, 2005 doi:10.1152/jn.00611.2005. We studied language and visuospatial functions of 12 children and adolescents who had undergone surgery for cerebellar astrocytoma without subsequent radiation or chemotherapy and compared them with 27 age-, gender-, and education-matched healthy control subjects. To study possible lateralization of the functions of the left and right cerebellar hemispheres, subjects performed several language tasks including a verb-generation task as well as standard neglect and extinction tests. Three-dimensional-MR images confirmed that lesions affected cerebellar hemispheres in all children but one who had a pure vermal lesion. The right cerebellar hemisphere was affected in six, the left hemisphere in four children, and both hemispheres in one child. There were no signs of aphasia in the children or adolescents with cerebellar lesions. Language abilities did not differ between cerebellar patients and control subjects except for small increases in reaction times in verb generation in patients with left-sided lesions. Visuospatial functions were also intact in cerebellar subjects except for minor group differences in neglect tasks. In sum, chronic focal cerebellar lesions acquired in childhood or youth do not result in persistent language disorders or clinically significant signs of spatial neglect or extinction.

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Cerebellar induced aphasia: case report of cerebellar induced prefrontal aphasic language phenomena supported by SPECT findings

Cited by 118 publications

References 61 publications

The Cerebellum and English Grammatical Morphology: Evidence from Production, Comprehension, and Grammaticality Judgments

The Cerebellum and English Grammatical Morphology: Evidence from Production, Comprehension, and Grammaticality Judgments

Grammar disruption in a patient with Neuro-Sweet syndrome

Children and Adolescents With Chronic Cerebellar Lesions Show No Clinically Relevant Signs of Aphasia or Neglect

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