Cerebellar Implant Studies

Larson, Sanford J.; Sances, Anthony; Cusick, Joseph F.; Myklebust, Joel B.; Millar, Edward A.; Boehmer, Robert D.; Hemmy, David C.; Ackmann, James J.; Swiontek, Thomas

doi:10.1109/tbme.1976.324592

Cited by 12 publications

(10 citation statements)

References 8 publications

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“…Median nerve stimulation was used [12], Evoked potentials were measured in the patients approximately 7 days after sur gery. In our previous studies, the alternate polarity electrodes caused minimal arti fact at the scalp during current application [10]. However, with the larger spaced superior-posterior cerebellar electrode systems, reported upon in this study, the electrical artifact at the scalp was approximately 1,000 times greater than the evoked potentials.…”

Section: Figcontrasting

confidence: 41%

“…While the mechanisms for reduction in generalized myoclonus may be different than those for reduction of amplitude of the SSEP, nevertheless clinical changes are observed at the same current levels which reduce the amplitude of the SSEP in the human [10,11].…”

Section: Discussionmentioning

confidence: 96%

“…Currents of 100 Hz applied to chronic electrodes of alternate polarity on the superior cerebellar surface of the chimpanzee and of the human have failed to demonstrate neuronal damage [10,11]. The somatosensory evoked potentials (SSEP) recorded from somatosensory cortex or scalp were depressed in amplitude at the current levels coincident with im proved motor function in patients with cerebral palsy, spastic torticollis, and multiple sclerosis [3,4,10,11,20].…”

mentioning

confidence: 99%

“…The somatosensory evoked potentials (SSEP) recorded from somatosensory cortex or scalp were depressed in amplitude at the current levels coincident with im proved motor function in patients with cerebral palsy, spastic torticollis, and multiple sclerosis [3,4,10,11,20]. A recent report indicates that cerebellar implants provide improvement in emotional status in patients with intractable psychiatric illness [7].…”

mentioning

confidence: 99%

“…A current density measuring probe, 0.3 mm on a side, was inserted with the measuring faces first parallel and then perpendicular to the axis of the brain stem. This method uses the loaded probe technique previously reported [10,19], The impedance in the region of the probe was also measured. Si nusoidal currents of 1,000 Hz, 2 mA rms, were applied to the total array by a Hew lett-Packard model 204B generator.…”

mentioning

confidence: 99%

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Evaluation of Electrode Configurations in Cerebellar Implants

Sances¹,

Larson²,

Myklebust³

et al. 1977

Stereotact Funct Neurosurg

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Capacitively coupled currents of 100 Hz, 0.25 msec duration, were applied to multielectrode arrays implanted upon the superior and posterior surfaces of the chimpanzee cerebellum. The current required for 90% reduction in the amplitude of the evoked potential was inversely proportional to the number of electrodes upon the cerebellar surface. A study of various waveforms showed that a 100 Hz, 0.25 msec pulse duration is near optimal for reduction of amplitude of the somatosensory evoked potential The current densities per electrode were 5–11 mA/cm² with a charge per pulse of 0.04–0.08 µC in humans with 15–20 electrodes on each superior surface and 10 electrodes on each posterior cerebellar surface.

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Section: Figcontrasting

confidence: 41%

Section: Discussionmentioning

confidence: 96%