Cerebellar-Dependent Learning in Larval Zebrafish

Aizenberg, Mark; Schuman, Erin M.

doi:10.1523/jneurosci.6565-10.2011

Cited by 102 publications

(90 citation statements)

References 20 publications

(17 reference statements)

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“…The use of perceptual timing tasks that allow investigation of how the fish perceives the duration of a stimulus or a sequence of stimuli is more plausible given the current technical limitations. A perceptual timing task can also be combined with restricted tail movement as some previous studies have shown promising results (CS -US conditioning in [69] and CS-entrained rhythms in [70]) in young larval fish, with minimum training required. It is also possible to train a larval fish in a different environment before imaging and then record the brain calcium signals to the same stimulus under a microscope, but this depends on how well a fish can generalize what it learned across different contexts.…”

Section: Future Interval-timing Studies Using Zebrafishmentioning

confidence: 99%

Zebrafish forebrain and temporal conditioning

Cheng

Jesuthasan

Penney

2014

Phil. Trans. R. Soc. B

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The rise of zebrafish as a neuroscience research model organism, in conjunction with recent progress in single-cell resolution whole-brain imaging of larval zebrafish, opens a new window of opportunity for research on interval timing. In this article, we review zebrafish neuroanatomy and neuromodulatory systems, with particular focus on identifying homologies between the zebrafish forebrain and the mammalian forebrain. The neuroanatomical and neurochemical basis of interval timing is summarized with emphasis on the potential of using zebrafish to reveal the neural circuits for interval timing. The behavioural repertoire of larval zebrafish is reviewed and we demonstrate that larval zebrafish are capable of expecting a stimulus at a precise time point with minimal training. In conclusion, we propose that interval timing research using zebrafish and whole-brain calcium imaging at single-cell resolution will contribute to our understanding of how timing and time perception originate in the vertebrate brain from the level of single cells to circuits.

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Section: Future Interval-timing Studies Using Zebrafishmentioning

confidence: 99%

Zebrafish forebrain and temporal conditioning

Cheng

Jesuthasan

Penney

2014

Phil. Trans. R. Soc. B

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“…Darland and Dowling, 2001;Sison and Gerlai, 2010;Bianco et al, 2011) and to forage in response to synthetic chemicals (Braubach et al, 2009). Young larvae (6-8 dpf ) can similarly be trained to exhibit tail-flicking behavior in response to light by pairing it with touching by a probe (Aizenberg and Schuman, 2011). The ability to perform associative learning increases with age.…”

Section: Larvae Learn To Sense Flowmentioning

confidence: 99%

Zebrafish learn to forage in the dark

Carrillo

McHenry

2016

Journal of Experimental Biology

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A large diversity of fishes struggle early in life to forage on zooplankton while under the threat of predation. Some species, such as zebrafish (Danio rerio), acquire an ability to forage in the dark during growth as larvae, but it is unclear how this is achieved. We investigated the functional basis of this foraging by video-recording larval and juvenile zebrafish as they preyed on zooplankton (Artemia sp.) under infrared illumination. We found that foraging improved with age, to the extent that 1-month-old juveniles exhibited a capture rate that was an order of magnitude greater than that of hatchlings. At all ages, the ability to forage in the dark was diminished when we used a chemical treatment to compromise the cranial superficial neuromasts, which facilitate flow sensing. However, a morphological analysis showed no developmental changes in these receptors that could enhance sensitivity. We tested whether the improvement in foraging with age could instead be a consequence of learning by raising fish that were naïve to the flow of prey. After 1 month of growth, both groups foraged with a capture rate that was significantly less than that of fish that had the opportunity to learn and indistinguishable from that of fish with no ability to sense flow. This suggests that larval fish learn to use water flow to forage in the dark. This ability could enhance resource acquisition under reduced competition and predation. Furthermore, our findings offer an example of learning in a model system that offers promise for understanding its neurophysiological basis.

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“…Nonassociative forms of learning, such as habituation and sensitization, were successfully shown in larval zebrafish (Best et al, 2008). However, associative forms of learning were only shown in a few studies at later developmental stages (Aizenberg and Schuman, 2011). The advantages of using early-stage zebrafish larvae include the large amount of offspring and the translucency of the animals, which allows for various in vivo imaging techniques visualizing neural activity during the actual behavior.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous alternation behavior in larval zebrafish

Bögli

Huang

2016

Journal of Experimental Biology

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Spontaneous alternation behavior (SAB) describes the tendency of animals to alternate their turn direction in consecutive turns. SAB, unlike other mnestic tasks, does not require any prior training or reinforcement. Because of its close correlation with the development and function of the hippocampus in mice, it is thought to reflect a type of memory. Adult zebrafish possess a hippocampus-like structure utilizing the same neurotransmitters as in human brains, and have thus been used to study memory. In the current study, we established SAB in zebrafish larvae at 6 days post-fertilization using a custommade forced-turn maze with a rate of 57%. Our demonstration of the presence of SAB in larval zebrafish at a very early developmental stage not only provides evidence for early cognition in this species but also suggests its future usefulness as a high-throughput model for mnestic studies.

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Cerebellar-Dependent Learning in Larval Zebrafish

Cited by 102 publications

References 20 publications

Zebrafish forebrain and temporal conditioning

Zebrafish forebrain and temporal conditioning

Zebrafish learn to forage in the dark

Spontaneous alternation behavior in larval zebrafish

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