Cerebellar defect and impaired motor coordination in mice lacking vimentin

Colucci‐Guyon, Emma; Ribotta, Minerva Giménez y; Maurice, Tangui; Babinet, Charles; Privat, Alain

doi:10.1002/(sici)1098-1136(19990101)25:1<33::aid-glia4>3.0.co;2-j

Cited by 105 publications

(39 citation statements)

References 43 publications

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“…Improved motor learning has been described in mice lacking the Purkinje cell protein 2/L7 (33), a G-protein modulator. Gene knock-out strains of Glast (34), vimentin (35), and neuronal cell adhesion protein (36) exhibit various defects in Bergmann glia cells but no enhancement of motor functions.…”

Section: Discussionmentioning

confidence: 99%

Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor

Marazziti

Pietro

Golini

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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In the developing cerebellum, the proliferation and differentiation of glial and neuronal cell types depend on the modulation of the sonic hedgehog (Shh) signaling pathway. The vertebrate Gprotein-coupled receptor 37-like 1 (GPR37L1) gene encodes a putative G-protein-coupled receptor that is expressed in newborn and adult cerebellar Bergmann glia astrocytes. This study shows that the ablation of the murine Gpr37l1 gene results in premature down-regulation of proliferation of granule neuron precursors and precocious maturation of Bergmann glia and Purkinje neurons. These alterations are accompanied by improved adult motor learning and coordination. Gpr37l1 −/− mice also exhibit specific modifications of the Shh signaling cascade. Specific assays show that in Bergmann glia cells Gpr37l1 is associated with primary cilium membranes and it specifically interacts and colocalizes with the Shh primary receptor, patched 1. These findings indicate that the patched 1-associated Gpr37l1 receptor participates in the regulation of postnatal cerebellum development by modulating the Shh pathway.mutant mouse model | mitogenic signaling

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Section: Discussionmentioning

confidence: 99%

Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor

Marazziti

Pietro

Golini

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…However, until recently, the functions of this IF protein remained elusive, as the phenotype of vimentin-deficient mice seemed to be relatively mild (93). More recently, detailed analyses of these mice have revealed significant defects pointing to involvement of vimentin in several cellular functions, including regulation of the morphology of glial cells (94). In addition, vimentin-knockout fibroblasts have deficiencies in motility and directional migration that affect wound healing and fibroblast migration (95,96).…”

Section: The Switch In the If Paradigm: From Structural Proteins To Mmentioning

confidence: 99%

Introducing intermediate filaments: from discovery to disease

Eriksson

Dechat²,

Grin³

et al. 2009

J. Clin. Invest.

380

366

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It took more than 100 years before it was established that the proteins that form intermediate filaments (IFs) comprise a unified protein family, the members of which are ubiquitous in virtually all differentiated cells and present both in the cytoplasm and in the nucleus. However, during the past 2 decades, knowledge regarding the functions of these structures has been expanding rapidly. Many disease-related roles of IFs have been revealed. In some cases, the molecular mechanisms underlying these diseases reflect disturbances in the functions traditionally assigned to IFs, i.e., maintenance of structural and mechanical integrity of cells and tissues. However, many disease conditions seem to link to the nonmechanical functions of IFs, many of which have been defined only in the past few years.

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“…During the development of the nervous system, vimentin is transiently expressed in virtually all the precursors cells of both neuronal and glial lineages. In the astroglial cell lineage, vimentin is the only IF protein expressed in radial glia and immature astrocytes in the embryonic nervous system (Alonso, 2001;Colluci-Guyon et al, 1999;Schnitzer et al, 1981). The expression of glial fibrillary acidic protein (GFAP), vimentin and fibronectin (Fn) was studied in cells cultured from human glioma and fetal brain by indirect immunofluorescence (IIF) microscopy and multiple labelling experiments (Paetau 1988).…”

Section: Discussionmentioning

confidence: 99%