Cerebellar-cerebral dynamic functional connectivity alterations in major depressive disorder

Zhu, Daomin; Yang, Ying; Zhang, Yu; Wang, Chunli; Wang, Yajun; Zhang, Cun; Zhao, Wenming; Zhu, Jiajia

doi:10.1016/j.jad.2020.06.062

Cited by 49 publications

(35 citation statements)

References 106 publications

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“…Recent study showed patients with MDD had decreased cerebellar-cerebral dynamic FC of the cerebellar subregions connecting with the executive, default-mode and affective-limbic networks. The dynamic FC of the cerebellar subregion connecting with the affective-limbic network was related to severity of depression and anxiety symptoms in MDD patients [45] .Our findings proved that migraine patients comorbid depression had decreased FC of cerebellum compared migraineurs. Thus we can consider cerebellum not only involve the processing of migraine pain but also plays a role in contribute to modulate cortical excitability in migraineurs with depression.…”

Section: Discussionsupporting

confidence: 60%

Alterations of Amygdala Volume and Functional Connectivity in Patients with Migraine Comorbid Depression

Chen¹,

Gui²,

Zu³

et al. 2021

Preprint

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Objective: The comorbidity of migraine and depressive has been recognized, but the pathophysiology remains unknown. Here, we aimed to explore the structural change of amygdala(AMY) and abnormal function in the centromedial amygdala (CMA) among migraineurs with depression. Methods: High-resolution T1-weighted and functional magnetic resonance images were acquired from subjects of 22 migraine comorbid with depression(EMwD ), 22 episodic migraine (EM), 20 major depressive disorder (MDD), respectively, and 18 healthy controls(HC). Apply voxel-based morphometry (VBM ) and resting state functional connectivity (rsFC) to examing inter-group differences in brain structure and function. Results: The volume of bilateral AMY increased in EMwD and EM compared to HC. EMwD showed larger volume than MDD. And the volume of AMY showed positive correlation with duration of illness in patient groups. Compared with EM, EMwD exhibited decreased rsFC between the right CMA and left cerebellum, left dorsolateral prefrontal cortex (DLPFC) , left precuneus(PCC). In addition, rsFC between the left CMA and left DLPFC was negatively correlated with Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD). Conclusions: According to our findings, the larger volume of amygdala and the abnormal functional connectivity may help to determining the common symptoms in migraine with depression, and may be a treatment target for migraine and depression comorbidities.

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Section: Discussionsupporting

confidence: 60%

Alterations of Amygdala Volume and Functional Connectivity in Patients with Migraine Comorbid Depression

Chen¹,

Gui²,

Zu³

et al. 2021

Preprint

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“…Because of the nature of constantly changing neural activity, increasing evidences have demonstrated that FC across brain regions is inherently dynamic, rather than simply static (18,19). Static and dynamic FC detect different aspects of abnormal neural activity in PD and can offer complementary evidence (20,21).…”

Section: Introductionmentioning

confidence: 99%

More Than Just Static: Dynamic Functional Connectivity Changes of the Thalamic Nuclei to Cortex in Parkinson's Disease With Freezing of Gait

et al. 2021

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Background: The thalamus is not only a key relay node of the thalamocortical circuit but also a hub in the regulation of gait. Previous studies of resting-state functional magnetic resonance imaging (fMRI) have shown static functional connectivity (FC) between the thalamus and the cortex are disrupted in Parkinson's disease (PD) patients with freezing of gait (FOG). However, temporal dynamic FC between the thalamus and the cortex has not yet been characterized in these patients.Methods: Fifty PD patients, including 25 PD patients with FOG (PD-FOG) and 25 PD patients without FOG (PD-NFOG), and 25 healthy controls (HC) underwent resting-state fMRI. Seed-voxel-wise static and dynamic FC were calculated between each thalamic nuclei and other voxels across the brain using the 14 thalamic nuclei in both hemispheres as regions of interest. Associations between altered thalamic FC based on significant inter-group differences and severity of FOG symptoms were also examined in PD-FOG.Results: Both PD-FOG and PD-NFOG showed lower static FC between the right lateral posterior thalamic nuclei and right inferior parietal lobule (IPL) compared with HC. Altered FC dynamics between the thalamic nuclei and several cortical areas were identified in PD-FOG, as shown by temporal dynamic FC analyses. Specifically, relative to PD-NFOG or HC, PD-FOG showed greater fluctuations in FC between the left intralaminar (IL) nuclei and right IPL and between the left medial geniculate and left postcentral gyrus. Furthermore, the dynamics of FC between the left pulvinar anterior nuclei and left inferior frontal gyrus were upregulated in both PD-FOG and PD-NFOG. The dynamics of FC between the right ventral lateral nuclei and left paracentral lobule were elevated in PD-NFOG but were maintained in PD-FOG and HC. The quantitative variability of FC between the left IL nuclei and right IPL was positively correlated with the clinical scales scores in PD-FOG.Conclusions: Dynamic FC between the thalamic nuclei and relevant associative cortical areas involved in sensorimotor integration or cognitive function was disrupted in PD-FOG, which was reflected by greater temporal fluctuations. Abnormal dynamic FC between the left IL nuclei of the thalamus and right IPL was related to the severity of FOG.

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“…As dFC analysis can extract more time-varying characteristics of information exchange between brain regions on a time scale and because these characteristics are significantly related to many physiological parameters ( 12 ), pathological features ( 13 ), and even intervention effects ( 14 ), dFC analysis seems to be particularly suitable for evaluating the complex and changeable characteristics of brain networks after stroke and exploring the neural mechanism of functional rehabilitation. Previous studies have shown that the proportion between integrated and segregated states was not balanced in patients who suffered from strokes ( 4 ) and that the temporal dynamics of FC were closely related to clinical severity ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

Low-Frequency Repetitive Transcranial Magnetic Stimulation Restores Dynamic Functional Connectivity in Subcortical Stroke

Qin

Guo

et al. 2021

Front. Neurol.

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Background and Purpose: Strokes consistently result in brain network dysfunction. Previous studies have focused on the resting-state characteristics over the study period, while dynamic recombination remains largely unknown. Thus, we explored differences in dynamics between brain networks in patients who experienced subcortical stroke and the effects of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on dynamic functional connectivity (dFC).Methods: A total of 41 patients with subcortical stroke were randomly divided into the LF-rTMS (n = 23) and the sham stimulation groups (n = 18). Resting-state functional MRI data were collected before (1 month after stroke) and after (3 months after stroke) treatment; a total of 20 age- and sex-matched healthy controls were also included. An independent component analysis, sliding window approach, and k-means clustering were used to identify different functional networks, estimate dFC matrices, and analyze dFC states before treatment. We further assessed the effect of LF-rTMS on dFCs in patients with subcortical stroke.Results: Compared to healthy controls, patients with stroke spent significantly more time in state I [p = 0.043, effect size (ES) = 0.64] and exhibited shortened stay in state II (p = 0.015, ES = 0.78); the dwell time gradually returned to normal after LF-rTMS treatment (p = 0.015, ES = 0.55). Changes in dwell time before and after LF-rTMS treatment were positively correlated with changes in the Fugl–Meyer Assessment for Upper Extremity (pr = 0.48, p = 0.028). Moreover, patients with stroke had decreased dFCs between the sensorimotor and cognitive control domains, yet connectivity within the cognitive control network increased. These abnormalities were partially improved after LF-rTMS treatment.Conclusion: Abnormal changes were noted in temporal and spatial characteristics of sensorimotor domains and cognitive control domains of patients who experience subcortical stroke; LF-rTMS can promote the partial recovery of dFC. These findings offer new insight into the dynamic neural mechanisms underlying effect of functional recombination and rTMS in subcortical stroke.Registration:http://www.chictr.org.cn/index.aspx, Unique.identifier: ChiCTR1800019452.

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Cerebellar-cerebral dynamic functional connectivity alterations in major depressive disorder

Cited by 49 publications

References 106 publications

Alterations of Amygdala Volume and Functional Connectivity in Patients with Migraine Comorbid Depression

Alterations of Amygdala Volume and Functional Connectivity in Patients with Migraine Comorbid Depression

More Than Just Static: Dynamic Functional Connectivity Changes of the Thalamic Nuclei to Cortex in Parkinson's Disease With Freezing of Gait

Low-Frequency Repetitive Transcranial Magnetic Stimulation Restores Dynamic Functional Connectivity in Subcortical Stroke

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