Cerebellar and other neurological soft signs in antipsychotic‐naïve schizophrenia

Varambally, Shivarama; Venkatasubramanian, Ganesan; Thirthalli, Jagadisha; Janakiramaiah, N.; Gangadhar, Bangalore N.

doi:10.1111/j.1600-0447.2006.00837.x

Cited by 55 publications

(50 citation statements)

References 28 publications

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“…Cerebellum, being part of the fronto-thalamic-cerebellar circuitry, has also been hypothesized to affect cognition (Picard et al, 2008). Taken together, the functional impact of cerebellar reduction is perplexing, and more towards NSS or cognition than typical schizophrenic symptoms (Picard et al, 2008; Varambally et al, 2006), which is in line with our findings of no significant correlation with positive or negative symptoms.…”

Section: Discussionsupporting

confidence: 91%

The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients

Liu

Chen

Ehrlich

et al. 2015

Schizophrenia Research

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Both methylation and brain volume patterns hold important biological information for the development and prognosis of schizophrenia (SZ). A combined study to probe the association between them provides a new perspective to understanding SZ. Genomic methylation of peripheral blood and regional brain volumes derived from magnate resonance imaging were analyzed using parallel independent component analyses in this study. Nine methylation components and five brain volumetric components were extracted for 94 SZ patients and 106 healthy controls. After controlling for age, sex, race, and substance use, a component comprised primarily of bilateral cerebellar volumes was significantly correlated to a methylation component from 14 CpG sites in 13 genes. Both patients and healthy controls demonstrated similar associations, but patients had significantly smaller cerebellar volumes and dysmethylation in the associated epigenetic component compared to controls. The 13 genes are enriched in cellular growth and proliferation with some genes involved in neuronal growth and cerebellum development (GATA4, ADRA1D, EPHA3, and KCNK10), and these genes are prominently associated with neurological and psychological disorders. Such findings suggest that the methylation pattern of the genes coding for cellular growth may influence the cerebellar development through regulating gene expression, and the alteration in the methylation of these genes in SZ patients may contribute to the cerebellar volume reduction observed in patients.

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Section: Discussionsupporting

confidence: 91%

The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients

Liu

Chen

Ehrlich

et al. 2015

Schizophrenia Research

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“…Patients under antipsychotic treatment (olanzapine, quetiapine, or clozapine) presented greater total score than neuroleptic naive patients in previous study [24]. Varambally et al have examined 32 schizophrenia patients and healthy controls using ICARS and NSS.…”

Section: Discussionmentioning

confidence: 99%

Relationship between cerebellar impairments and lexicon retrieval in schizophrenia - preliminary study

Chrobak¹,

Biela²,

Siuda³

et al. 2013

Arch Psych Psych

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SummaryAim of the study. Investigation of relationship between cerebellar motor dysfunctions and language impairments connected with cerebellum during phonological and semantic fluency tasks and verb generation task in schizophrenic patients and healthy control group. Subject or material and methods. 14 schizophrenic patients on olanzapine, clozapine or quetiapine treatment and 13 healthy volunteers were examined. Motor signs were assessed by using the International Co-operative Ataxia Rating Scale (ICARS). Phonological and semantic fluency tasks were performed. All of the words were recorded and counted. Results. Patients with schizophrenia revealed significantly higher ICARS mean score (12.21) than control group (3.92), and lower number of proper generated words in semantic fluency and verb generation tasks. Strong negative correlation (rs(13) = -0.71, p<0.01) was found between ICARS total score and number of proper answers in verb generation task. Discussion. Higher number of total ICARS score in schizophrenia patients in comparison to control group may suggest cerebellar impairments. There is disproportion between semantic and phonological fluency. Significant correlation between verb generation and cerebellar signs supports a hypothesis of cerebellum dysfunction during this task in schizophrenia patients. Conclusions. Schizophrenic patients reveal impairments which may be connected with the cerebellum. schizophrenia / verb generation / cerebellum / cognitive dysmetria

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“…CSS total score, posture subscore and oculomotor subscore had significant positive correlation with a negative syndrome score. [32]…”

Section: Neurodevelopmental Hypothesis Of Schizophrenia - Evidence Basementioning

confidence: 99%

Schizophrenia is a disorder of aberrant neurodevelopment: A synthesis of evidence from clinical and structural, functional and neurochemical brain imaging studies

Venkatasubramanian

2007

Indian J Psychiatry

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Cerebellar and other neurological soft signs in antipsychotic‐naïve schizophrenia

Abstract: Findings support intrinsic cerebellar dysfunction in schizophrenia. The observations are discussed in relationship with cognitive dysmetria.

Cited by 55 publications

References 28 publications

The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients

The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients

Relationship between cerebellar impairments and lexicon retrieval in schizophrenia - preliminary study

Schizophrenia is a disorder of aberrant neurodevelopment: A synthesis of evidence from clinical and structural, functional and neurochemical brain imaging studies

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