Cerebellar Agenesis: A Case to Remember

Abstract

There is a wide range of congenital anomalies of the posterior fossa. Of these, absence of cerebellar components seems to exist on a spectrum, much like anomalies seen with the more frequently encountered Dandy–Walker malformation. Here, we present a rare case of cerebellar agenesis, as seen at our institution, which falls on the extreme side of the spectrum. We also discuss normal and aberrant posterior fossa development, established or hypothesized genetic causes of such development, and implications on cerebellar function.

Cerebellar Agenesis: Two Case Reports With Review

“…Can another part take over if one part is damaged? (09) The development plasticity and functional compensation seen with the remaining brain tissue when cerebellar deficiency is arising very early during embryogenesis is remarkable (10). Only mild to moderate motor deficiency, ataxia dysarthria with mild mental impairment is seen in patient 1 having complete absence of cerebellum (11).…”