Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

Belo, José António; Bouwmeester, Tewis; Leyns, Luc; Kertesz, Nathalie; Gallo, Maria F; Follettie, Maximillian T.; Robertis, E. M. De

doi:10.1016/s0925-4773(97)00125-1

Cited by 430 publications

(342 citation statements)

References 36 publications

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“…First, polarity and, therefore, pattern appears to already exist in the epiblastal ectoderm before gastrulation as evinced by asymmetric patterns of gene expression typically encountered within epiblast (e.g., Bmp4,Otx2,Fgf8,T [Brachury],Cripto,Wnt3,Nodal,Hesx1,Hex,, VE-1, Lim1 [Lhx1], GATA, Dlx, and Dkk1; Lawson et al, 1991;Lawson and Pedersen, 1992;Dono et al, 1993;Simeone et al, 1993;Ang and Rossant, 1994;Crossley and Martin, 1995;Belo et al, 1997;Varlet et al, 1997;Eyal-Giladi, 1997;Beddington and Robertson, 1998;Biben et al, 1998;Ding et al, 1998;Shawlot et al, 1998;Thomas et al, 1998;Liu et al, 1999;Pera et al, 1999;Crossley et al, 2001;Tian et al, 2002;Chapman et al, 2002). This asymmetry is mirrored by the underlying hypoblast (visceral endoderm;e.g., Otx2, Lim1, Hesx1, Hex, HNF3␤, Lefty1, Nodal (Acampora et al, 1995;Thomas and Beddington, 1996;Belo et al, 1997;Filosa et al, 1997;Varlet et al, 1997;Thomas et al, 1998;Meno et al, 1999;Shimono and Berhinger, 1999;Kim...…”

Section: First Perambulations: Polarity and Pattern In The Pregastrulmentioning

confidence: 99%

“…This asymmetry is mirrored by the underlying hypoblast (visceral endoderm;e.g., Otx2, Lim1, Hesx1, Hex, HNF3␤, Lefty1, Nodal (Acampora et al, 1995;Thomas and Beddington, 1996;Belo et al, 1997;Filosa et al, 1997;Varlet et al, 1997;Thomas et al, 1998;Meno et al, 1999;Shimono and Berhinger, 1999;Kimura et al, 2001). …”

Section: First Perambulations: Polarity and Pattern In The Pregastrulmentioning

confidence: 99%

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21^st Century neontology and the comparative development of the vertebrate skull

Depew

Simpson

2006

Developmental Dynamics

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Classic neontology (comparative embryology and anatomy), through the application of the concept of homology, has demonstrated that the development of the gnathostome (jawed vertebrate) skull is characterized both by a fidelity to the gnathostome bauplan and the exquisite elaboration of final structural design. Just as homology is an old concept amended for modern purposes, so are many of the questions regarding the development of the skull. With due deference to Geoffroy-St. Hilaire, Cuvier, Owen, Lankester et al., we are still asking: How are bauplan fidelity and elaboration of design maintained, coordinated, and modified to generate the amazing diversity seen in cranial morphologies? What establishes and maintains pattern in the skull? Are there universal developmental mechanisms underlying gnathostome autapomorphic structural traits? Can we detect and identify the etiologies of heterotopic (change in the topology of a developmental event), heterochronic (change in the timing of a developmental event), and heterofacient (change in the active capacetence, or the elaboration of capacity, of a developmental event) changes in craniofacial development within and between taxa? To address whether jaws are all made in a like manner (and if not, then how not), one needs a starting point for the sake of comparison. To this end, we present here a "hinge and caps" model that places the articulation, and subsequently the polarity and modularity, of the upper and lower jaws in the context of cranial neural crest competence to respond to positionally located epithelial signals. This model expands on an evolving model of polarity within the mandibular arch and seeks to explain a developmental patterning system that apparently keeps gnathostome jaws in functional registration yet tractable to potential changes in functional demands over time. It relies upon a system for the establishment of positional information where pattern and placement of the "hinge" is driven by factors common to the junction of the maxillary and mandibular branches of the first arch and of the "caps" by the signals emanating from the distal-most first arch midline and the lamboidal junction (where the maxillary branch meets the frontonasal processes). In this particular model, the functional registration of jaws is achieved by the integration of "hinge" and "caps" signaling, with the "caps" sharing at some critical level a developmental history that potentiates their own coordination. We examine the evidential foundation for this model in mice, examine the robustness with which it can be applied to other taxa, and examine potential proximate sources of the signaling centers. Lastly, as developmental biologists have long held that the anterior-most mesendoderm (anterior archenteron roof or prechordal plate) is in some way integral to the normal formation of the head, including the cranial skeletal midlines, we review evidence that the seminal patterning influences on the early anterior ectoderm extend well beyond the neural plate and are just as importan...

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Section: First Perambulations: Polarity and Pattern In The Pregastrulmentioning

confidence: 99%

Section: First Perambulations: Polarity and Pattern In The Pregastrulmentioning

confidence: 99%

21^st Century neontology and the comparative development of the vertebrate skull

Depew

Simpson

2006

Developmental Dynamics

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“…This is due, in part, to the relative lack of genetic markers of this tissue. Many genes that are expressed in the definitive endoderm, such as Hex, Cer1, Foxa2, and Sox17, are also expressed in the extraembryonic visceral endoderm (Ang et al, 1993;Belo et al, 1997;Biben et al, 1998;Shawlot et al, 1998;Thomas et al, 1998;Hallonet et al, 2002;KanaiAzuma et al, 2002). A second limitation of these definitive endoderm markers is that they are not expressed in the entire definitive endoderm at any point during gastrulation but instead only mark specific regions of the definitive endoderm.…”

Section: Introductionmentioning

confidence: 99%

Dynamic expression of Thyrotropin‐releasing hormone in the mouse definitive endoderm

McKnight¹,

Hou²,

Hoodless³

2007

Developmental Dynamics

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Thyrotropin-releasing hormone (TRH) is a well-characterized regulator of the hypothalamic-pituitary-thyroid endocrine axis. Here, we describe the expression of Trh during early embryonic development in the mouse. We find Trh to be highly expressed during postimplantation stages in the mouse embryo, with expression first observed in the epiblast at embryonic day (E) 6.5. During gastrulation, Trh is expressed in the newly formed definitive endoderm cells, and at embryonic day (E) 7.75, marks the entire definitive endoderm. Subsequently, Trh mRNA levels rapidly decrease such that, by E9.0, expression in the definitive endoderm is no longer detected, after which neural expression predominates. Thus, Trh is expressed dynamically and specifically in the developing mouse definitive endoderm from E7.0 to E8.5. Trh is unique among definitive endoderm markers as it transiently marks the entire definitive endoderm population and is not expressed in the extraembryonic endoderm. Trh will be a valuable tool to study definitive endoderm formation in the mouse embryo.

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“…Embryos were fixed in 4% paraformaldehyde on ice for 1 hour and processed as described for whole-mount in situ hybridization (Belo et al, 1997). Alternatively, embryos were fixed in 4% paraformaldehyde overnight at 4°C, cryoprotected in 30% sucrose and embedded in TissueTek (Sakura).…”

Section: In Situ Hybridizationmentioning

confidence: 99%

Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development

Geng

Lavado

Lagutin

et al. 2007

Gene Expression Patterns

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Recently, sequence analyses have identified a large number of opposite strands transcripts in the vertebrate genome. Although the transcripts appear to be spliced and polyadenylated, many of them are predicted to represent noncoding RNAs. High levels of noncoding transcripts of the Six3 opposite strand (Six3OS) were recently identified in the embryonic and postnatal retina of the mouse. In this study, we expanded those initial expression analyses, elucidated in detail the developmental expression profile of mouse Six3OS in the brain and visual system, and compared it with that of Six3. Our results show that Six3OS expression overlaps extensively with that of Six3 and is not altered in Six3-null embryos.

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Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

Cited by 430 publications

References 36 publications

21^st Century neontology and the comparative development of the vertebrate skull

21^st Century neontology and the comparative development of the vertebrate skull

Dynamic expression of Thyrotropin‐releasing hormone in the mouse definitive endoderm

Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development

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Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

Cited by 430 publications

References 36 publications

21st Century neontology and the comparative development of the vertebrate skull

21st Century neontology and the comparative development of the vertebrate skull

Dynamic expression of Thyrotropin‐releasing hormone in the mouse definitive endoderm

Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development

Contact Info

Product

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21^st Century neontology and the comparative development of the vertebrate skull

21^st Century neontology and the comparative development of the vertebrate skull