Cerasomes: A New Family of Artificial Cell Membranes with Ceramic Surface

Kikuchi, Jun‐ichi

doi:10.5772/14167

Cited by 7 publications

(6 citation statements)

References 63 publications

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“…In these mixtures, one may suggest that APTES is hydrolyzed and can further condense to form Si–O–Si bonds yielding aminosilane oligomers. The final structure of the vesicles is probably very similar to that of cerasome. − These later vesicles are formed by using a synthetic lipid on which is anchored an inorganic, silica precursor. In water, condensation of silica groups occurs forming a ceramic layer at the surface of the bilayers.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, APTES has already been used in combination with fatty acid derivatives (via ion-pairing) in concentrated systems with the purpose of building chiral solid porous silicate materials . Recently, phospholipids bearing a silicate headgroup were synthesized and shown to self-assemble into vesicles and polymerize yielding the formation of artificial-cell like systems with a ceramic surface called “cerasome”. − …”

Section: Introductionmentioning

confidence: 99%

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Aminosilane/Oleic Acid Vesicles as Model Membranes of Protocells

et al. 2014

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Oleic acid vesicles represent good models of membrane protocells that could have existed in prebiotic times. Here, we report the formation, growth polymorphism, and dynamics of oleic acid spherical vesicles (1-10 μm), stable elongated vesicles (>50 μm length; 1-3 μm diameter), and chains of vesicles (pearl necklaces, >50 μm length; 1-3 μm diameter) in the presence of aminopropyl triethoxysilane and guanidine hydrochloride. These vesicles exhibit a remarkable behavior with temperature: spherical vesicles only are observed when keeping the sample at 4 °C for 2 h, and self-aggregated spherical vesicles occur upon freezing/unfreezing (-20/20 °C) samples. Rather homogeneous elongated vesicles are reformed upon heating samples at 80 °C. The phenomenon is reversible through cycles of freezing/heating or cooling/heating of the same sample. Deuterium NMR evidences a chain packing rigidity similar to that of phospholipid bilayers in cellular biomembranes. We expect these bilayered vesicles to be surrounded by a layer of aminosilane oligomers, offering a variant model for membrane protocells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aminosilane/Oleic Acid Vesicles as Model Membranes of Protocells

et al. 2014

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“…Therefore, maintaining the vesicular structure of liposomal membranes to mimic the molecular interactions in cell membranes to express biological functions remains a challenge. 11 Kikuchi et al 12,13 developed cerasomes, which are a novel kind of organic-inorganic nanohybrid material composed of a spherical lipid bilayer membrane with an internal aqueous phase similar to liposomes and then the surface of the lipid bilayer is covered with an ultrathin inorganic silicate framework. The inorganic framework increases the morphological stability of cerasomes compared with that of conventional liposomes.…”

Section: Introductionmentioning

confidence: 99%

A biocompatible cerasome based platform for direct electrochemistry of cholesterol oxidase and cholesterol sensing

Chen

Liu

et al. 2016

RSC Adv.

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“…9 Several attempts have been previously made to introduce an organic–inorganic hybrid structure to artificial lipid membranes in a lamellar phase. 10 Synthetic lipids with an alkoxysilyl head group spontaneously form lipid bilayers with a ceramic-like siloxane on the surface of the lipid bilayer through the sol–gel reaction consisting of hydrolysis and following polycondensation in an aqueous solution. In particular, cerasome, an organic–inorganic hybrid vesicle 10 a – e , g as well as a hybrid bicelle, 10 f a discoidal lipid assembly with a siloxane surface have been developed so far.…”

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confidence: 99%