Ceramides and glycosphingolipids in maturation process: leukemic cells as an experimental model

Smoleńska-Sym, Gabriela; Spychalska, Justyna; Zdebska, Ewa; Woźniak, Jolanta; Traczyk, Z; Pszenna, Ewa; Maj, Stanisław; Danikiewicz, Witold; Bieńkowski, Tomasz; Kościelak, Jerzy

doi:10.1016/j.bcmd.2004.04.002

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…Owing to the close interaction between lipid metabolism and other cellular processes, such as energy homeostasis, gene regulation, membrane trafficking, and protein metabolism, it is clear that data from lipidomics studies are essential to comprehend the system as a whole. Finally, knowing the regulatory networks of lipid homeostasis is critical to tackling how its deregulation contributes to diseases, such as metabolic syndrome, Alzheimer disease, and genetic disorders of lipid catabolism ( Outeiro and Muchowski, 2004 ; Smolenska-Sym et al. , 2004 ; Cookson et al.…”

Section: Resultsmentioning

confidence: 99%

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis

Santos

Riezman

Aguilera-Romero

et al. 2014

MBoC

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Section: Resultsmentioning

confidence: 99%

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis

Santos

Riezman

Aguilera-Romero

et al. 2014

MBoC

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“…With respect to neutral GSLs, human neutrophils express GlcCer, LacCer, and a set of (neo)lacto-series GSLs, but no globoside has been detected (23, 31–33, 35, 39, 88). During differentiation of the promyelocyte cell line HL60 toward granulocytes using all-trans retinoic acid or phorbol myristate acetate (PMA), the (neo)lacto-series synthase B3GNT5 was upregulated (21, 89).…”

Section: Biosynthesis and Expression Of Gsls In Naïve And Differentiamentioning

confidence: 99%

The Role of Glycosphingolipids in Immune Cell Functions

et al. 2019

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Glycosphingolipids (GSLs) exhibit a variety of functions in cellular differentiation and interaction. Also, they are known to play a role as receptors in pathogen invasion. A less well-explored feature is the role of GSLs in immune cell function which is the subject of this review article. Here we summarize knowledge on GSL expression patterns in different immune cells. We review the changes in GSL expression during immune cell development and differentiation, maturation, and activation. Furthermore, we review how immune cell GSLs impact membrane organization, molecular signaling, and trans-interactions in cellular cross-talk. Another aspect covered is the role of GSLs as targets of antibody-based immunity in cancer. We expect that recent advances in analytical and genome editing technologies will help in the coming years to further our knowledge on the role of GSLs as modulators of immune cell function.

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“…Neutrophilic and monocytic differentiations are also often accompanied by changes in N-glycan, ganglioside and neutral GSL expression (Saito 1993;McEver et al 1995;Hinkovska-Galcheva et al 1998;Liu et al 1998;Cooling et al 2003). In leukemic cells, GSLs have been found to be biomarkers of successive maturation stages (Yu 1994;Smolenska-Sym et al 2004). For example, in HL-60 cells, granulocytic and monocytic differentiations are accompanied by distinct changes in ganglioside synthesis and expression (Nakamura et al 1992).…”

Section: Introductionmentioning

confidence: 99%

High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients

Wang

Wen

et al. 2012

Glycobiology

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Glycosphingolipids (GSLs) are information-bearing biomolecules that play critical roles in embryonic development, signal transduction and carcinogenesis. Previous studies indicate that certain GSLs are associated with differentiation in acute myeloid leukemia (AML) cells. In this study, we collected bone marrow samples from healthy donors and AML patients and analyzed the GSL expression profiles comprehensively using electrospray ionization linear ion-trap mass spectrometry. The results showed that AML patients had higher expression of the GSL lactotriaosylceramide (Lc3), GM3 and neolactotetraosylceramide (nLc4) in their bone marrow than did the healthy donors (P < 0.05), especially the M1 subtype of AML. To further explore the molecular mechanisms of Lc3, we examined the expression of the Lc3 synthase β1,3-N-acetylglucosaminyltransferase5 (β3Gn-T5) and found that the bone marrow samples of AML patients had 16-fold higher expression of β3Gn-T5 than those of healthy donors (P < 0.05). Our results suggest that AML-associated GSLs Lc3, GM3 and nLc4 are possibly involved in initiation and differentiation of AML.

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Ceramides and glycosphingolipids in maturation process: leukemic cells as an experimental model

Cited by 6 publications

References 49 publications

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis

The Role of Glycosphingolipids in Immune Cell Functions

High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients

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