Ceramide synthases: Reflections on the impact of Dr. Lina M. Obeid

Kim, Jiyoon L.; Mestre, Beatriz; Shin, Sunhye; Futerman, Anthony H.

doi:10.1016/j.cellsig.2021.109958

Cited by 24 publications

(22 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ceramide synthase (CerS) can then catalyze the formation of dihydroceramide (dhCer) through the incorporation of acyl-CoA of different chain lengths to sphinganine. There are six different isoforms of CerS (CerS1-6) identified in mammals and plants [28]. Specifically, CerS1 is highly expressed in the nervous system and skeletal muscles, but is almost undetectable in other types of tissue.…”

Section: The De Novo Pathwaymentioning

confidence: 99%

Ceramide Metabolism and Parkinson’s Disease—Therapeutic Targets

et al. 2021

View full text Add to dashboard Cite

Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to being the precursor of complex sphingolipids, ceramides can act as second messengers, especially when they are generated at the plasma membrane of cells. Its metabolic dysfunction may lead to or be a consequence of an underlying disease. Recent reports on transcriptomics and electrospray ionization mass spectrometry analysis have demonstrated the variation of specific levels of sphingolipids and enzymes involved in their metabolism in different neurodegenerative diseases. In the present review, we highlight the most relevant discoveries related to ceramide and neurodegeneration, with a special focus on Parkinson’s disease.

show abstract

Section: The De Novo Pathwaymentioning

confidence: 99%

Ceramide Metabolism and Parkinson’s Disease—Therapeutic Targets

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The sphingolipid (SL 1 ) biosynthetic pathway begins with the condensation of an amino acid, normally serine, with a fatty acyl CoA, J o u r n a l P r e -p r o o f normally palmitoyl CoA, to generate 3ketosphinganine, followed by the action of 3ketosphinganine reductase to generate sphinganine (1). The latter is then N-acylated by (dihydro)ceramide synthases (CerSs), which can also N-acylate the sphingosine that is generated in the recycling pathway (2). Thus, dihydroceramide generation requires the input of two acyl CoAs.…”

Section: Introductionmentioning

confidence: 99%

Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis

Kim

Mestre

Malitsky

et al. 2022

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

“…Transmembrane spanning Ceramide synthase (CERS1) is a key enzyme in sphingolipid metabolism using acyl-CoA to generate ceramides with various acyl chain lengths that regulate differentiation, proliferation, and apoptosis (24). Structure information is not available for any of the CerS enzymes, there are no homologs with known structures, and the number and orientation of its transmembrane helices (TMH) are not known (25). The RoseTTAFold CERS1 model for residues 98 to 304 (Pfam TLC domain) (26) includes six TMH that traverse the membrane in an up and down arrangement (Fig.…”

mentioning

confidence: 99%

Accurate prediction of protein structures and interactions using a 3-track network

Baek

DiMaio

Anishchenko

et al. 2021

Preprint

122

133

View full text Add to dashboard Cite

DeepMind presented remarkably accurate protein structure predictions at the CASP14 conference. We explored network architectures incorporating related ideas and obtained the best performance with a 3-track network in which information at the 1D sequence level, the 2D distance map level, and the 3D coordinate level is successively transformed and integrated. The 3-track network produces structure predictions with accuracies approaching those of DeepMind in CASP14, enables rapid solution of challenging X-ray crystallography and cryo-EM structure modeling problems, and provides insights into the functions of proteins of currently unknown structure. The network also enables rapid generation of accurate models of protein-protein complexes from sequence information alone, short circuiting traditional approaches which require modeling of individual subunits followed by docking. We make the method available to the scientific community to speed biological research.

show abstract

Ceramide synthases: Reflections on the impact of Dr. Lina M. Obeid

Cited by 24 publications

References 121 publications

Ceramide Metabolism and Parkinson’s Disease—Therapeutic Targets

Ceramide Metabolism and Parkinson’s Disease—Therapeutic Targets

Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis

Accurate prediction of protein structures and interactions using a 3-track network

Contact Info

Product

Resources

About