Ceramic scaffolds for biomaterials applications

Swain, Shasank S.; Swain, P.; Parida, Saroj Kumar; Rautray, Tapash R.

doi:10.1016/b978-0-323-99626-6.00016-0

Cited by 3 publications

(1 citation statement)

References 114 publications

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“…In the case of cellular adhesion and osteogenic cell proliferation, the polarization of the sample leads to an increased charge, which facilitates the attraction of cells to the surface of the sample. This interaction between the sample and the cells can promote the growth and differentiation of osteogenic cells, which is a crucial process for the formation of bone tissue [59].…”

Section: Resultsmentioning

confidence: 99%

Magnesium-Substituted Hydroxyapatite /Spider Silk fibroin /N-Carboxymethyl Chitosan Based Microsphere: A potential template for bone regeneration

Swain,

Mishra,

Das

et al. 2024

Preprint

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Ageing, sedentary lifestyle and bone trauma have contributed to a sequel of clinical manifestation and risk factors associated with bone health. However, there are constant efforts made by researchers on both invasive and non-invasive strategies for a revival of bone architecture. In recent years, biomaterials, primarily biocomposites, have improved the facet of bone repair and regeneration. In the present work, a biocomposite of spider silk fibroin (SSF), N-caboxymethyl chitosan (N-CMCh) and magnesium (Mg2+) incorporated hydroxyapatite (HA), i.e. SSF/N-CMCh/Mg-HA was prepared to fabricate microspheres for bone regenerative applications. Initially, synthetic stoichiometric HA doped with Mg was synthesized by wet chemical method. The crystallographic property of Mg2+ incorporation in HA was investigated by XRD analysis. SEM-EDX and FTIR confirmed even distribution of the element and stoichiometric ratio of Ca:P along with Mg2+ in the biocomposite. A comparative analysis of the polarized SSF/N-CMCh/Mg-HA and SSF/N-CMCh was carried out to analyse the porosity and swelling of the fabricated microspheres. In vitro evaluation confirms the cellular metabolic viability of the microspheres. Further, Mg-HA-incorporated microspheres showed better protein absorption with enhanced ALP activity. Improved biocompatibility of the microspheres could be confirmed with high expression of osteogenic gene markers such as ALP, OCN, RUNX2, and COL-1. The studies confirmed that the fabricated SSF/N-CMCh/Mg-HA microspheres could be used as a potential template for bone regeneration.

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Section: Resultsmentioning

confidence: 99%

Magnesium-Substituted Hydroxyapatite /Spider Silk fibroin /N-Carboxymethyl Chitosan Based Microsphere: A potential template for bone regeneration

Swain,

Mishra,

Das

et al. 2024

Preprint

Self Cite

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Preparation of Eggshell Derived HA-BT Composite for Biomedical Applications

Mishra,

Swain,

Rautray

2024

Integrated Ferroelectrics

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ZnO-doped β-TCP ceramic-based scaffold promotes osteogenic and antibacterial activity

Mangaraj,

Priyadarshini,

Swain

et al. 2024

Bioinspired, Biomimetic and Nanobiomaterials

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β-tricalcium phosphate (β-TCP) scaffold, a synthetic bone graft material, has been explored as a potential solution in the healing of bone deformities due to its acceptable degradation rate and ability to support bone growth. However, these scaffolds have limitations such as poor mechanical properties, to stimulate bone growth, and an increased risk of infection after implantation. To overcome these issues, a new type of biomedical scaffold has been developed that incorporated ZnO particles into β-TCP using wet chemical techniques. The scaffolds were created using sintering to produce porous β-TCP scaffolds with good connectivity. The addition of ZnO as a dopant significantly improved the biophysical properties of the scaffolds, with higher concentrations of ZnO leading to better cell adhesion and proliferation. The scaffolds placed in SBF demonstrated their exceptional ability to promote bone growth and regeneration by developing a bone-like apatite layer on their surfaces. The mechanical and physical properties of the scaffolds were effectively assessed using XRD and SEM analyses. To validate the efficacy of the specimen in preventing microbial growth and promoting bone growth, an MTT test, and gene expression investigation were conducted. ZnO-doped β-TCP scaffolds are envisaged to show enormous potential for use in future bone healing applications.

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Ceramic scaffolds for biomaterials applications

Cited by 3 publications

References 114 publications

Magnesium-Substituted Hydroxyapatite /Spider Silk fibroin /N-Carboxymethyl Chitosan Based Microsphere: A potential template for bone regeneration

Magnesium-Substituted Hydroxyapatite /Spider Silk fibroin /N-Carboxymethyl Chitosan Based Microsphere: A potential template for bone regeneration

Preparation of Eggshell Derived HA-BT Composite for Biomedical Applications

ZnO-doped β-TCP ceramic-based scaffold promotes osteogenic and antibacterial activity

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