Ceramic nanoparticles: Recompense, cellular uptake and toxicity concerns

Singh, Deependra; Singh, Satpal; Sahu, Jageshwari; Srivastava, Shikha; Singh, Manju Rawat

doi:10.3109/21691401.2014.955106

Cited by 79 publications

(44 citation statements)

References 62 publications

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“…In vivo experiments have revealed that carbon nanotubes are found to cause dose-dependent epithelioid granulomatous lesions in the lung and persistent interstitial inflammation on chronic exposure [ 40 , 41 ]. Furthermore, ceramic nanoparticles, commonly used for drug delivery, have been reported to exhibit oxidative stress/cytotoxic activity in the lungs, liver, heart, and brain, as well as have teratogenic/carcinogenic effects [ 42 ].…”

Section: Toxicity Of Nanoparticlesmentioning

confidence: 99%

Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death

et al. 2015

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Nanoparticles are emerging as a useful tool for a wide variety of biomedical, consumer and instrumental applications that include drug delivery systems, biosensors and environmental sensors. In particular, nanoparticles have been shown to offer greater specificity with enhanced bioavailability and less detrimental side effects as compared to the existing conventional therapies in nanomedicine. Hence, bionanotechnology has been receiving immense attention in recent years. However, despite the extensive use of nanoparticles today, there is still a limited understanding of nanoparticle-mediated toxicity. Both in vivo and in vitro studies have shown that nanoparticles are closely associated with toxicity by increasing intracellular reactive oxygen species (ROS) levels and/or the levels of pro-inflammatory mediators. The homeostatic redox state of the host becomes disrupted upon ROS induction by nanoparticles. Nanoparticles are also known to up-regulate the transcription of various pro-inflammatory genes, including tumor necrosis factor-α and IL (interleukins)-1, IL-6 and IL-8, by activating nuclear factor-kappa B (NF-κB) signaling. These sequential molecular and cellular events are known to cause oxidative stress, followed by severe cellular genotoxicity and then programmed cell death. However, the exact molecular mechanisms underlying nanotoxicity are not fully understood. This lack of knowledge is a significant impediment in the use of nanoparticles in vivo. In this review, we will provide an assessment of signaling pathways that are involved in the nanoparticle-induced oxidative stress and propose possible strategies to circumvent nanotoxicity.

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Section: Toxicity Of Nanoparticlesmentioning

confidence: 99%

Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death

et al. 2015

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“…In the context of the ceramic industry, many reports show that occupational exposure to ceramic dusts and fibres is associated with chronic bronchitis, chronic obstructive pulmonary disease, reduced lung function, wheezing, breathlessness and dry cough (Jaakkola et al, 2011;Kargar et al, 2013;Trethowan et al, 1995). (Bakand et al, 2012;Li et al, 2010;Paur et al, 2011;Pietroiusti et al, 2018 ;Stone et al, 2017 (Singh et al, 2016).…”

Section: General Remarksmentioning

confidence: 99%

Nanoparticle exposure and hazard in the ceramic industry: an overview of potential sources, toxicity and health effects

Bessa

Brandão

Viana

et al. 2020

Environmental Research

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The ceramic industry is an industrial sector of great impact in the global economy that has been benefitting from advances in materials and processing technologies. Ceramic manufacturing has a strong potential for airborne particle formation and emission, namely of ultrafine particles (UFP) and nanoparticles (NP), meaning that workers of those industries are risk of potential exposure to these particles. At present, little is known on the impact of engineered nanoparticles (ENP) on the environment and human health and no established Occupational Exposure Limits (OEL) or specific regulations to airborne nanoparticles (ANP) exposure exist raising concerns about the possible consequences of such exposure. In this paper, we provide an overview of the current knowledge on occupational exposure to NP in the ceramic industry and their impact on human health. Possible sources and exposure scenarios, a summary of the existing methods for evaluation and monitoring of ANP in the workplace environment and proposed Nano Reference Values (NRV) for different classes of NP are presented. Case studies on occupational exposure to ANP generated at different stages of the ceramic manufacturing process are described. Finally, the toxicological potential of intentional and unintentional ANP that have been identified in the ceramic industry workplace environment is discussed based on the existing evidence from in vitro and in vivo inhalation toxicity studies.

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“…The components most commonly used in ceramic nanoparticles are silica and aluminum. However, the core of these nanoparticles is not limited to these two materials; in fact, they can be composed of a combination of metallic and nonmetallic materials [ 28 ]. For instance, CeO 2 -capped mesoporous silica nanoparticles (MSN) have been developed to act as vehicles for drug delivery by releasing β -cyclodextrin into lung cancer cells [ 29 ].…”

Section: Nanoparticles In Medicinementioning

confidence: 99%

Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress

Mauricio

Guerra-Ojeda

Marchio

et al. 2018

Oxidative Medicine and Cellular Longevity

149

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Nanotechnology has had a significant impact on medicine in recent years, its application being referred to as nanomedicine. Nanoparticles have certain properties with biomedical applications; however, in some situations, they have demonstrated cell toxicity, which has caused concern surrounding their clinical use. In this review, we focus on two aspects: first, we summarize the types of nanoparticles according to their chemical composition and the general characteristics of their use in medicine, and second, we review the applications of nanoparticles in vascular alteration, especially in endothelial dysfunction related to oxidative stress. This condition can lead to a reduction in nitric oxide (NO) bioavailability, consequently affecting vascular tone regulation and endothelial dysfunction, which is the first phase in the development of cardiovascular diseases. Therefore, nanoparticles with antioxidant properties may improve vascular dysfunction associated with hypertension, diabetes mellitus, or atherosclerosis.

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Ceramic nanoparticles: Recompense, cellular uptake and toxicity concerns

Cited by 79 publications

References 62 publications

Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death

Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death

Nanoparticle exposure and hazard in the ceramic industry: an overview of potential sources, toxicity and health effects

Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress

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