Ceramic cement as a potential stand-alone treatment for bone fractures: An in vitro study of ceramic–bone composites

Koh, Ilsoo; Gombert, Yvonne; Persson, Cecilia; Engqvist, Håkan; Helgason, Benedikt; Ferguson, Stephen J.

doi:10.1016/j.jmbbm.2016.03.027

Cited by 4 publications

(5 citation statements)

References 36 publications

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“…The test was done under load control using 500-N load cell. 12 Eight specimens for each concentration were tested.…”

Section: Methodsmentioning

confidence: 99%

“…Based on extensive literature review, the mechanical property of PMMA bone cement is measured using several methods. [12][13][14] The forces tested were three-point bending and axial loading (compression) only, due to the limitation of resources and financial constrain. Stiffness (brittle) was calculated from the stress-strain curve.…”

Section: Mechanical Testing Of Antibiotic-loaded Pmmamentioning

confidence: 99%

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Addition of ceftaroline fosamil or vancomycin to PMMA: An in vitro comparison of biomechanical properties and anti-MRSA efficacy

Haseeb

Singh

Teh

et al. 2019

J Orthop Surg (Hong Kong)

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Background: Ceftaroline is a cephalosporin that is effective against methicillin-resistant Staphylococcus aureus (MRSA) infections. The objective of this study was to determine the feasibility of using ceftaroline-loaded Polymethyl methacrylate (PMMA) as antibiotic cement against MRSA versus vancomycin-loaded PMMA in an in vitro setting. Methods: PMMA pellets were prepared with three separate concentrations of each of the two antibiotics tested. They were tested to determine the effect of increasing concentration of antibiotics on the biomechanical properties of PMMA and antibiotic activity by measuring the zone of inhibition and broth elution assay. Results: Ceftaroline PMMA at 3 wt%, three-point bending was 37.17 + 0.51 N (p < 0.001) and axial loading was 41.95 N + 0.51 (p < 0.001). At 5-wt% vancomycin-PMMA, three-point bending was 41.65 + 0.79 N (p ¼ 0.02) and axial loading was 49.49 + 2.21 N (p ¼ 0.01). Stiffness of ceftroline-loaded PMMA in low and medium concentration was significantly higher than the vancomycin. The zone of inhibition for ceftaroline was higher than vancomycin. Ceftaroline at 3 wt% eluted up to 6 weeks (0.3 + 0.1 mg/ml) above the minimum inhibitory concentration (MIC) and vancomycin at 2.5 wt% eluted up to 3 weeks, same as MIC, that is, 0.5 + 0.0 mg/ml. Conclusions: Ceftaroline, loaded at similar concentrations as vancomycin into PMMA, is a more potent alternative based on its more favourable bioactivity and elution properties, while having a lesser effect on the mechanical properties of the cement. The use of 3-wt% ceftaroline as antibiotic laden PMMA against MRSA is recommended. It should be noted that this was an in vitro study and to determine the clinical efficacy would need prospective, controlled and randomized studies.

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“…The test was done under load control using 500-N load cell. 12 Eight specimens for each concentration were tested.…”

Section: Methodsmentioning

confidence: 99%

Section: Mechanical Testing Of Antibiotic-loaded Pmmamentioning

confidence: 99%

Addition of ceftaroline fosamil or vancomycin to PMMA: An in vitro comparison of biomechanical properties and anti-MRSA efficacy

Haseeb

Singh

Teh

et al. 2019

J Orthop Surg (Hong Kong)

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“…The composite and cement specimens were prepared using a polytetrafluoroethylene (PTFE) split-mold [19] (Fig. 2).…”

Section: Cement Augmentationmentioning

confidence: 99%

Mechanical and morphological characterization of PMMA/bone composites in human femoral heads

Sas

Helgason

Ferguson

et al. 2021

Journal of the Mechanical Behavior of Biomedical Materials

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PMMA has gained an important place in a variety of orthopaedic applications in the femur. However, appropriate data on the mechanical properties of bone-cement composites from the human femur are lacking. Therefore, the goal of this study was to determine the morphological and quasi-static compressive properties of proximal femoral bone-cement composites. Thirty trabecular bone specimens were extracted from fifteen pairs of human femoral heads using specimen-specific cutting guides to ensure an accurate alignment with the main trabecular direction (MTD). One specimen from each pair was augmented with PMMA bone cement, while the other one was left untreated. Specimens were scanned with µCT to determine morphological parameters and tested in quasi-static compression until failure. We found that the long axis of the specimens was highly aligned with the MTD (mean error < 5°). A higher compressive modulus and ultimate strength were observed for the bone-cement composite specimens (E = 5.7 ± 0.4 GPa; = 77.9 ± 5.1 MPa) compared to the bone only specimens (E = 2.9 ± 0.7 GPa; = 19.0 ± 5.8 MPa). Furthermore, the composites had a higher modulus, but lower strength than cement itself (E = 5.0 ± 0.3 GPa; = 85.9 ± 2.7 MPa) and the composite modulus was significantly correlated with the bone volume fraction (BV/TV). These results are in contrast to previous findings on human vertebral bone, where the composite was more compliant than cement and no correlation was found between BV/TV and the composite modulus. Thus, properties of bone-cement composites cannot simply be applied across different anatomical sites; the site-specific differences in bone density and trabecular alignment should be taken into account. Collectively, the present results suggest that at low BV/TV, cement dominates the composite properties, while at high BV/TV, the contribution of bone becomes apparent, revealing a positive relationship between BV/TV and the on-axis modulus.

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“… Acidentes envolvendo choques, traumas, patologias, deformações congênitas do ramo do côndilo e mordidas acidentais com objetos duros (LANDES et al, 2013) 1979).…”

Section: Lista De Equaçõesunclassified

“…A mandíbula é o maior e mais forte osso do crânio, cuja forma característica de ferradura é unitária e com simetria bilateral. Para explicar a complexidade do comportamento ósseo, uma analogia desse material com os cerâmicos pode ser adotada (KOH et al, 2016;MALMSTRÖM et al, 2016;INGOLE, 2018), visto que a tensão de tração é mais agravante do que a tensão de compressão no quesito fratura. A ruptura dos ossos apresenta a fratura do tipo frágil, com ausência da região de deformação plástica.…”

Section: Anatomia Do Crâniounclassified

Desenvolvimento e análise de um modelo de mecanismo aplicado a prótese de Articulação Temporomandibular (ATM)

Idogava¹

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Agradecimentos especiais ao Professor Gregory Bregion Daniel por aceitar o desafio de um tema interdisciplinar, por toda atenção ao longo do trabalho, pelas conversas descontraídas e bem-humoradas no laboratório e por sempre encontrar uma solução ao longo dos desafios que enfrentamos. Agradecimentos ao Professor Pedro Yoshito Noritomi pela primeira oportunidade de contato com a área de bioengenharia pelos casos de apoio do Núcleo de Tecnologias Tridimensionais (NT3D) do Centro de Tecnologia da Informação Renato Archer e pelos conselhos tanto profissionais quanto pessoais. Agradecimentos à Universidade Estadual de Campinas e a todo o corpo docente e de funcionários da Faculdade de Engenharia Mecânica por mudar os rumos de minha vida desde 2011 e por sempre me proporcionar um ambiente sadio de conhecimento. Agradecimentos à equipe do Departamento de Tecnologias Tridimensionais do CTI Renato Archer e a todos os profissionais da área da saúde que visitaram a instituição pelas conversas produtivas e trocas de conhecimento. Em especial ao chefe da equipe Jorge Vicente Lopes da Silva e pela supervisão e atenção nos treinamentos de Daniel Takanori Kemmoku. Agradecimentos ao Grupo do Laboratório de Máquinas Rotativas (LAMAR) por toda ajuda e suporte ao longo dos projetos desenvolvidos durante o mestrado.Agradecimento ao suporte financeiro das instituições: Pró-

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Ceramic cement as a potential stand-alone treatment for bone fractures: An in vitro study of ceramic–bone composites

Cited by 4 publications

References 36 publications

Addition of ceftaroline fosamil or vancomycin to PMMA: An in vitro comparison of biomechanical properties and anti-MRSA efficacy

Addition of ceftaroline fosamil or vancomycin to PMMA: An in vitro comparison of biomechanical properties and anti-MRSA efficacy

Mechanical and morphological characterization of PMMA/bone composites in human femoral heads

Desenvolvimento e análise de um modelo de mecanismo aplicado a prótese de Articulação Temporomandibular (ATM)

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