CERAD test performance and cognitive impairment in Parkinson's disease

Karrasch, Mira; Laatu, Sari; Martikainen, Kirsti; Marttila, Reijo J.

doi:10.1111/ane.12138

Cited by 19 publications

(22 citation statements)

References 23 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also includes tests of frontostriatal, executive functions, including verbal fluency and clock drawing. In fact, we recently showed significant differences in several CERAD subtests between patients with PD who were functioning normally in everyday life and those who did have cognitive problems affecting everyday functioning . There were significant effects in executive subtests, but the largest effects were observed in visuospatial function, learning and delayed recall, which supports the notions that as cognitive functioning deteriorates in PD, the domains affected include the frontostriatally mediated executive functions and free recall, as well as more posterior‐cortical functions (e.g., visuospatial functions) .…”

Section: Introductionmentioning

confidence: 57%

Education-corrected CERAD identifies MCI and dementia in Parkinson's disease

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 57%

Education-corrected CERAD identifies MCI and dementia in Parkinson's disease

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nonetheless, it has to be mentioned that the sensitivity of MMSE to detect executive dysfunction and language deficits remains controversial . Therefore, in this study a comprehensive neuropsychological test battery including the CERAD‐plus test battery, the digit span test, the Frontal Assessment Battery, the clock drawing task, and the Hospital Anxiety and Depression Scale were used. Our study shows that approximately 40% of patients had a documented slight to moderate cognitive impairment in at least one domain, wherein executive functions were most often affected in line with previous findings .…”

Section: Discussionmentioning

confidence: 99%

Cognition in multiple system atrophy: a single‐center cohort study

Eschlböck

Delazer

Krismer

et al. 2020

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Objective Cognitive impairment in multiple system atrophy (MSA) is common, but remain poorly characterized. We evaluated cognitive and behavioral features in MSA patients and assessed between‐group differences for MSA subtypes and the effect of orthostatic hypotension (OH) on cognition. Methods This retrospective study included 54 patients with clinical diagnosis of possible and probable MSA referred to the Department of Neurology at Medical University of Innsbruck between 2000 and 2018. Neurological work‐up included comprehensive neuropsychological testing including Consortium to Establish a Registry for Alzheimer's Disease (CERAD‐plus) test battery, Frontal Assessment Battery (FAB), digit span test (DST), clock drawing task (CLOX1), and Hospital Anxiety and Depression Scale (HADS‐D). Results The mean MMSE score was 27.6 points. Overall, slight to moderate cognitive impairment was noted in up to 40% of patients, with predominant impairment of executive function and verbal memory. Patients with the cerebellar variant performed significantly worse than patients with the parkinsonian type (P < 0.05) in a screening of executive functions (FAB) and in phonemic verbal fluency. Depression and anxiety scores were elevated in 28% and 22% of MSA patients, respectively. Cognitive profile, depression, and anxiety levels were comparable between patients with and without OH. Interpretation Cognitive deficits are relatively frequent in MSA and primarily affect executive functions and verbal memory. Future comparative studies including Parkinson dementia, Lewy body disease, and MSA cases with and without OH are required to elucidate disease‐specific cognitive profiles in these synucleinopathies and to examine the influence of cardiovascular autonomic dysfunction on cognitive function in MSA.

show abstract

“…The participants were assessed for cognitive performance by the neuropsychological test battery of 'The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-Neuropsychological Assessment Battery' (Memory Clinic University Hospital Basel, 2005). A detailed description of the CERAD test battery is published elsewhere (Karrasch et al, 2013;Chandler et al, 2005). The following four cognitive domains are assessed by the subtests of the CERAD-Plus: semantic memory, episodic memory, constructional praxis, and executive function.…”

Section: Assessment Of Cognitive Functionsmentioning

confidence: 99%