Cephalosporin's induced hepatic enzyme derangement - An educational report

Vitamin C Ameliorates the Cefepime-Induced Changes of Liver Enzymes, Histopathology and Proinflammatory Cytokines in Male Albino Rats

“…In the current study, lipid vacuolations were observed in the hepatocytes of cefepime treated rats, such phenomenon was supported by the findings which suggested that cefepime interferes with the correlation of RNA with ribosomes, leading to lacking of protein building information which is a reason for the depletion in the synthesis of lipid acceptor protein in the hepatocytes, leading to inability of triglycerides to leave the hepatocytes resulting in accumulation of lipid inside the hepatocytes. 42,49 Histopathological examination of the liver of cefepime-treated rats showed scattered apoptotic cells, the cause of such apoptosis may be attributed to the drug which stimulated an intrinsic intracellular pathway which may cause inhibition of DNA and RNA synthesis and delayed or inhibited the cell division 50,51 , thus causing nuclear DNA damage. IL1β and TNFα cytokines are endowed with an outstanding tissue-damaging potential, including induction of apoptosis.…”