Cephalosporin P

KORZYBSKI, TADEUSZ; KOWSZYK-GINDIFER, ZUZANNA; KURYŁOWICZ, WŁODZIMIERZ

doi:10.1016/b978-1-4831-9801-9.50100-8

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…The antibiotics in this complex have been distinguished from the previously known actinomycins by comparison of their hydrolysis products with those ofthe known compounds (1,2,(4)(5)(6)(7)(8)(9). The components have as constituent parts both known amino and imino acids as well as amino and imino acids that have not previously been shown to be constituents of actinomycin antibiotics.…”

Section: Resultsmentioning

confidence: 99%

A New Actinomycin Complex Produced by a Micromonospora Species: Fermentation, Isolation, and Characterization

Wagman¹,

Marquez²,

Watkins³

et al. 1976

Antimicrob Agents Chemother

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A species of Micromonospora, Micromonospora floridensis NRRL 8020, has been found to produce an actinomycin complex consisting of at least 25 active components. After solvent extraction of the complex, separation of the individual components was carried out by preparative thin-layer chromatography. Hydrolysis and subsequent electrophoretic and chromatographic identification of the amino acid content of each of the isolated components have shown differences from known actinomycins, and the probability exists that these contain a number of amino or imino acids not previously found in other members of this group of antibiotics.

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Section: Resultsmentioning

confidence: 99%

A New Actinomycin Complex Produced by a Micromonospora Species: Fermentation, Isolation, and Characterization

Wagman¹,

Marquez²,

Watkins³

et al. 1976

Antimicrob Agents Chemother

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“…Strains s18, 532, SI79 and s187 were constructed as recombinants in crosses between derivatives of strain ~3(2). Streptomyces griseus produces the antibiotic grisin (grisemin) (Korzybski, Kowszyk-Gindifer & Kurylowicz, 1969;Krasilnikov, 1970). A derivative, ~8 0 6 , which produced more antibiotic than wild-type strains of S. griseus ~r.15, was selected after a single treatment of S. griseus Kr.…”

Section: E T H O D Smentioning

confidence: 99%

Construction and Properties of Hybrids Obtained in Interspecific Crosses between Streptomyces coelicolor A3(2) and Streptomyces griseus Kr. 15

Lomovskaya

Voeykova

Mkrtumian

1977

Journal of General Microbiology

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S U M M A R Y Recombinants between Streptomyces coelicolor ~3 ( 2 )and Streptomyces griseus ~r .15 were obtained using methods of hybrid construction. Recombinant RcgI, obtained from a cross between S. griseus and a S. coelicolor UF (SCPI-) strain, phenotypically resembled S. coelicolor UF strains and in crosses with a S. coelicolor NF donor strain produced recombinant progeny at a frequency of roo %. Recombinant Rcg3, like SCPI-carrying S. coelicolor strains, inhibited SCPI-strains of S. coelicolor and in crosses with a UF recipient strain of S. coelicolor generated recombinants at high frequency. In crosses between S. griseus and RcgI the frequency of recombinant formation was increased about roo-fold relative to crosses between S. griseus and S. coelicolor. Effective transfer of S. griseus and Rcg3 chromosomal markers into RcgI and S. coelicolor, respectively, indicated that S. griseus had donor properties.Studies of the ability of recombinants to support phage growth indicated that parental chromosomal fragments containing genes involved in control of phagereceptor formation and intracellular growth were present in the hybrids. Grisinproducing recombinants, capable of restricting phages attacking S. coelicolor and S. griseus, were obtained.

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Cephalosporin P

Cited by 2 publications

References 5 publications

A New Actinomycin Complex Produced by a Micromonospora Species: Fermentation, Isolation, and Characterization

A New Actinomycin Complex Produced by a Micromonospora Species: Fermentation, Isolation, and Characterization

Construction and Properties of Hybrids Obtained in Interspecific Crosses between Streptomyces coelicolor A3(2) and Streptomyces griseus Kr. 15

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