Cephalosporin‐induced Nonconvulsive Status Epilepticus: Clinical and Electroencephalographic Features

Cefepime-Induced Nonconvulsive Status Epilepticus: Case Report and Review

“…The epileptogenic side effect of b-lactam antibiotics was first described in 1945 [2]. Cephalosporins, particularly cefepime, have been associated with NCSE, especially in adult patients with impaired renal function [3][4][5][6][7][8][9][10][11][12][13][14][15].…”

Cefepime Therapy and All‐Cause Mortality

“…Nursing, medical, and pharmacy staff should become more aware of the signs and symptoms of encephalopathy and nonconvulsive status epilepticus in patients who are being treated with cefepime. It should be noted that patients treated with cefepime did have higher rates of encephalopathy and nonconvulsive status epilepticus than did patients treated with other b-lactams [16][17][18][19]. The signs and symptoms of encephalopathy include delirium, acute confusion, impaired attention or memory, decreased alertness, and disorientation.…”

“…Second, these conditions should not always result in death. Third, patients with severe renal failure-an important risk factor for the above-mentioned conditions [16][17][18][19]-were not included in the studies analyzed. In their meta-analysis, Yahav et al [10] assumed that these conditions caused significant increased mortality, which is more a speculation than a plausible explanation.…”

De novoabsence status epilepticus of late onset (DNASLO) precipitated by oral treatment with cefuroxime: description of an ambulatory case

“…The administration of IVBZDs is considered key in making a "definitive" diagnosis of NCSE (Kaplan, 1999), and is routine practice in our department (Fernández-Torre et al, 2012). However, it is likely that both the use of antiepileptic drugs and the interruption of cephalosporin therapy led to faster clinical improvement, and arguably reduced complications and the potential for brain damage (Fernández-Torre et al, 2005). The resolution of the clinical and EEG anomalies after treatment with short-acting antiepileptic drugs is diagnostic of NCSE (Kaplan, 2005).…”