Cephalometric craniofacial features of patients with Sagliker syndrome: a primary analysis of our experience

Mi, Jiaoping; He, Peng; Shi, Kai; Feng, Shaoyan; Chen, Xianzhen; He, Qi; Zhao, Mingyue; Ge, Pingjiang; Fan, Yunping

doi:10.21037/atm-21-1544

Cited by 5 publications

(3 citation statements)

References 16 publications

(14 reference statements)

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“…The study from China-Japan Friendship Hospital revealed that craniofacial changes in SS patients occurred exclusively at speci c sites with the maxillary body enlarged especially in sagittal and vertical directions, and the anterior part of mandibula increased in the vertical direction. Meanwhile, gender, age, dialysis age and higher serum alkaline phosphatase (ALP) level might be the progression risk factors for SS [20,21]. The high levels of ALP and PTH can lead to high transport bone diseases with incomplete new bone structures and vulnerability to fractures.…”

Section: Discussionmentioning

confidence: 99%

Sagliker Syndrome: A case of Chronic Renal Failure with Uncontrolled Secondary Hyperparathyroidism

Gu¹,

Xue²,

et al. 2023

Preprint

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Man, 55-year-old, developed Sagliker syndrome (SS) in the course of hemodialysis for end-stage renal disease from 2008, as a result of uncontrolled secondary hyperparathyroidism (SHPT). His medical managements failed and he had no chance of kidney transplantation. Although surgical parathyroidectomy was rejected and the disease development could not be reversed, PTH began to decline and SS progressed slowly under the control of management and guidance in medication treatment. It is possible that such patients can survive with long-time dialysis, but the prevention of severe SHPT is critical.

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Section: Discussionmentioning

confidence: 99%

Sagliker Syndrome: A case of Chronic Renal Failure with Uncontrolled Secondary Hyperparathyroidism

Gu¹,

Xue²,

et al. 2023

Preprint

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“…Las manifestaciones clínicas detectadas en la paciente se relacionan con las descritas por otros autores, entre ellas las características de perfil facial convexo y maloclusiones debido a la protusión del ángulo maxilar en relación al ángulo mandibular 14 , la estatura baja, el crecimiento del hueso escapular, el acortamiento con curvatura hacia arriba de las falanges distales, la deformidad de las rodillas, las escápulas y ciertas alteraciones en la marcha 1,15 . Por otra parte, algunos autores mencionan otros hallazgos que son menos frecuentes, como alteraciones neurológicas moderadas a severas, entre ellas cefaleas y anormalidades auditivas 15 .…”

Section: Discussionunclassified

Abordaje quirúrgico de tumor pardo de maxilar en síndrome de Sagliker

Fuentes

Cruz

2022

Alerta (San Salvador)

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Presentación del caso. Se trata de una paciente femenina de 20 años de edad con enfermedad renal crónica estadio 5 en tratamiento de hemodiálisis que notó aumento progresivo de la región palatina en los últimos siete meses, que le generaba dislalia y dificultad para la masticación con expansión del hueso maxilar, separación de las piezas dentales superiores y cambios en la configuración y perfil facial compatibles con un tumor pardo. Los resultados de laboratorio confirmaron un hiperparatiroidismo e hipocalcemia secundarios a la enfermedad renal. Los hallazgos ecográficos fueron compatibles con hiperplasia de paratiroides del lado izquierdo. Intervención terapéutica. Se administró carbonato de calcio y paricalcitol durante las dos semanas previas a la cirugía. El tratamiento consistió en una paratiroidectomía subtotal y la resección quirúrgica de la tumoración en el maxilar y los suplementos de calcio y vitamina D3 por vía oral. Evolución clínica. Se obtuvo normalización de los niveles de calcio y de fósforo y disminuyeron los niveles de la paratohormona. Después de un seguimiento de más de dos años, no se identificaron recurrencias.

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“…The etiology of secondary hyperparathyroidism is complex. There are not only genetic factors, but also many other stimulating factors, such as low calcium, high phosphorus, and insufficient calcitriol ( 8 ). For patients with Sagliker syndrome, there is currently no effective treatment.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of secondary hyperparathyroidism combined with Sagliker syndrome caused by chronic renal failure: a case report

Pang¹,

Meng²

2022

Gland Surg

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Background: Sagliker syndrome is caused by severe secondary hyperparathyroidism in hemodialysis patients with chronic renal failure. It is mainly manifested by disturbances of calcium and phosphorus metabolism and bone changes, which eventually lead to abnormal changes in facial appearance and morphology, seriously affecting the quality of life of patients. With the improvement of management mode and technology for hemodialysis in chronic renal failure, the incidence of severe secondary hyperparathyroidism related to hemodialysis is relatively reduced. Therefore, Sagliker syndrome is more rare. How to early identify and choose the appropriate treatment for Sagliker syndrome is particularly important.Case Description: A 34-year-old female patient with uremia, who underwent regular hemodialysis at the Blood Purification Center of Tianjin Third Central Hospital, developed Sagliker syndrome. The general data, clinical symptoms, height changes, biochemical indicators (serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, hemoglobin, and hematocrit), and parathyroid emission computerized tomography (ECT) were collected and analyzed. The patient had a history of hemodialysis with chronic renal failure for 6 years, and presented with bone pain for 2 years. Laboratory tests showed parathyroid hormone was 2,269 pg/mL and ECT showed 3 parathyroid hyperplasia. Finally, total parathyroidectomy and forearm transplantation were performed. The level of parathyroid hormone was significantly lower than that before the operation. On the first postoperative day, the level of parathyroid hormone decreased to 28.3 pg/mL. Four months later, the bone pain symptoms of the patient were significantly improved compared with those before the operation.Conclusions: Sagliker syndrome is a special syndrome in maintenance hemodialysis patients with refractory secondary hyperparathyroidism. Early monitoring and standardized treatment of secondary hyperparathyroidism may prevent the occurrence of Sagliker syndrome. Early identification and diagnosis of Sagliker syndrome and the choice of appropriate treatment will have an important impact for the prognosis.

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Cephalometric craniofacial features of patients with Sagliker syndrome: a primary analysis of our experience

Cited by 5 publications

References 16 publications

Sagliker Syndrome: A case of Chronic Renal Failure with Uncontrolled Secondary Hyperparathyroidism

Sagliker Syndrome: A case of Chronic Renal Failure with Uncontrolled Secondary Hyperparathyroidism

Abordaje quirúrgico de tumor pardo de maxilar en síndrome de Sagliker

Surgical treatment of secondary hyperparathyroidism combined with Sagliker syndrome caused by chronic renal failure: a case report

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