Cephalic index correlates poorly with intracranial volume in non-syndromic scaphocephalic patients

Leikola, Junnu; Koljonen, Virve; Heliövaara, Arja; Hukki, Jyri; Koivikko, Mika P.

doi:10.1007/s00381-014-2456-x

Cited by 21 publications

(13 citation statements)

References 28 publications

(30 reference statements)

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“…However, the same study indicates that CI has poor correlation with measures overall hemispheric asymmetry. Similarly, in patients with sagittal synostosis, CI has shown poor correlation with intracranial volume, highlighting that CI may not be a valid craniometric measurement (Leikola et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Comparing Cephalic Index and Midsagittal Vector Analysis in Assessing Morphology in Sagittal Synostosis: A CT-Based Morphometric Analysis

Hong

Zellner

et al. 2018

The Cleft Palate-Craniofacial Journal

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Introduction: Assessment of cranial dysmorphism in sagittal synostosis is often subjective but objective measures can be applied. These include cephalic index (CI) and midsagittal vector analysis (MSVA). Objective: To assess discriminant validity, construct validity, and responsiveness of CI and MSVA measured from computed tomography (CT) in patients with sagittal synostosis. Methods: Patients with nonsyndromic isolated sagittal synostosis with complete preoperative (n = 30) and postoperative (n = 13) CT data were included. Age-matched control group (n = 24) comprised of normocephalic patients who underwent CT for reasons related to trauma. Outcome Measures: Retrospective CT evaluation of CI and MSVA was conducted and correlated with a dysmorphism numeric rating scale (D-NRS) that measured surgeon-rated severity of sagittal synostosis. Responsiveness of CI and MSVA was evaluated using dysmorphism global rating of change (D-GRC). Results: Thirty patients with sagittal synostosis were demographically similar to 24 normocephalic patients. The difference in CI and MSVA was statistically significant between normocephalic and scaphocephalic patients. Cephalic index had a good correlation with D-NRS ( r = −0.665, ρ = −0.667), but not with MSVA ( r = 0.250, ρ = 0.203). Change in CI ( r = 0.738, ρ = 0.657) was well correlated with D-GRC, but not with MSVA ( r = −0.409, ρ = −0.301). Conclusion: Cephalic index appears to quantify the severity of sagittal synostosis better than MSVA. Cephalic index also has better responsiveness than MSVA to measure a reduction in severity of disease; however, MSVA is a better descriptive craniometric measurement. Midsagittal vector analysis was able to quantify the shift in morphology in sagittal synostosis following surgical treatment.

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Section: Discussionmentioning

confidence: 99%

Comparing Cephalic Index and Midsagittal Vector Analysis in Assessing Morphology in Sagittal Synostosis: A CT-Based Morphometric Analysis

Hong

Zellner

et al. 2018

The Cleft Palate-Craniofacial Journal

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“…This work flow is admittedly too complicated and unnecessarily exact for clinical use, but automated segmentation algorithms have shown excellent results [15]. Volume estimates and indices from simple three-plane measurements do not reliably reflect the ICV and are, in our experience, obsolete [16].…”

Section: Siv Measurementmentioning

confidence: 99%

Length of synostosis and segmented intracranial volume correlate with age in patients with non-syndromic sagittal synostosis

et al. 2017

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“…All CTs were obtained using a 64-slice scanner (LightSpeed VCT). The following parameters were used: helical full, 0.5-second rotation time, increment of 39.37 mm/rotation (pitch 0.984:1), and 100 kV at 40 mA and 120 kV at 50 mA of tube current for those aged less and over 1.5, respectively, with images reconstructed at a thickness of 0.625 mm at 0.312-mm intervals (Leikola et al, 2014). Invaginations of teeth were classified according to the Oehlers classification system (Oehlers, 1957).…”

Section: Methodsmentioning

confidence: 99%

Dental Age, Agenesis, and Morphology in Patients With Operated Single-Suture Craniosynostoses

Leinonen

Rice

Leikola

et al. 2020

The Cleft Palate-Craniofacial Journal

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Objective: The aim of this study was to evaluate the dental age, agenesis, and morphology of children with surgically operated single-suture craniosynostoses from orthopantomographs. Design: A single-centered cross-sectional observational archival study. Patients: A sample of 196 Finnish patients with single-suture craniosynostosis without additional birth defects or syndromes (excluding Muenke syndrome) was included in this study. Main Outcome Measures: Dental age was assessed using the method developed by Demirjian et al. and modified by Nyström et al. for the Finnish population. Methods described by Tulensalo et al. and Oehlers et al. were used to study taurodontism and dens invaginatus, respectively. Results: The study sample of 149 patients was divided into 3 groups: patients with sagittal synostosis (n = 103), coronal synostosis (n = 25), and metopic synostosis (n = 21). Orthopantomographs taken on average at ages 8.20 to 8.33 were used. The dental ages in different groups were on average 0.37, 0.60, and 0.66 years ahead of normative values, for sagittal, coronal, and metopic groups, respectively. Tooth agenesis, taurodontism, and invaginated teeth were found in all groups with invaginations having a high prevalence. Peg-shaped upper lateral incisors and one geminated lower lateral incisor were also found. Conclusions: These descriptive data may help improve dental care in patients with single-suture craniosynostosis.

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Cephalic index correlates poorly with intracranial volume in non-syndromic scaphocephalic patients

Abstract: Cephalic index correlates poorly with intracranial volume in non-syndromic scaphocephalic patients. For some patients, surgery and growth resulted in only subtle or no change in CI despite a notable increase in intracranial volume.

Cited by 21 publications

References 28 publications

Comparing Cephalic Index and Midsagittal Vector Analysis in Assessing Morphology in Sagittal Synostosis: A CT-Based Morphometric Analysis

Comparing Cephalic Index and Midsagittal Vector Analysis in Assessing Morphology in Sagittal Synostosis: A CT-Based Morphometric Analysis

Length of synostosis and segmented intracranial volume correlate with age in patients with non-syndromic sagittal synostosis

Dental Age, Agenesis, and Morphology in Patients With Operated Single-Suture Craniosynostoses

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