CeO2 nanoparticles improve prooxidant/antioxidant balance, life quality and survival of old male rats

Nikitchenko, Yuri V.; Klochkov, Vladimir K.; Kavok, Nataliya; Karpenko, N. A.; Yefimova, Svetlana; Semynozhenko, V.P.; Nikitchenko, Irina V.; Божков, А. И.

doi:10.1007/s10522-022-09987-6

Cited by 8 publications

(4 citation statements)

References 69 publications

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“…It is known that CeO 2 degrades in physiological body fluids, resulting in the release of CeO 2 . [23] In our study, the degradation rate of CeO 2 could be adjusted by pH value, where a lower pH value significantly promoted CeO 2 degradation (Figure 1e). Additionally, the release of CeO 2 could be retarded by surface MSN and Ag coating, and the retained CeO 2 decreased with decreasing pH.…”

Section: Characterizations Of Ag@msn@ceo 2 Npssupporting

confidence: 51%

Enhancing Infected Diabetic Wound Healing through Multifunctional Nanocomposite‐Loaded Microneedle Patch: Inducing Multiple Regenerative Sites

Yu,

Chen,

Yan

et al. 2024

Adv Healthcare Materials

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Infected diabetic wound (DW) presents a prolonged and challenging healing process within the field of regenerative medicine. The effectiveness of conventional drug therapies is hindered by their limited ability to reach deep tissues and promote adequate wound healing rates. Therefore, there is an imperative to develop drug delivery systems that can penetrate deep tissues while exhibiting multifunctional properties to expedite wound healing. In this study, we devised a soluble microneedle (MN) patch made of γ‐PGA, featuring multiple arrays, which was loaded with core‐shell structured nanoparticles (NPs) known as Ag@MSN@CeO2, to enhance the healing of infected DWs. The NP comprises a CeO2 core with anti‐inflammatory and antioxidant properties, a mesoporous silica NP (MSN) shell with angiogenic characteristics, and an outermost layer doped with Ag to combat bacterial infections. We demonstrated that the MN platform loaded with Ag@MSN@CeO2 successfully penetrated deep tissues for effective drug delivery. These MN tips induced the formation of multiple regenerative sites at various points, leading to antibacterial, reactive oxygen species‐lowering, macrophage ecological niche‐regulating, vascular regeneration‐promoting, and collagen deposition‐promoting effects, thus significantly expediting the healing process of infected DWs. Considering these findings, the multifunctional MN@Ag@MSN@CeO2 patch exhibits substantial potential for clinical applications in the treatment of infected DW.This article is protected by copyright. All rights reserved

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Section: Characterizations Of Ag@msn@ceo 2 Npssupporting

confidence: 51%

Enhancing Infected Diabetic Wound Healing through Multifunctional Nanocomposite‐Loaded Microneedle Patch: Inducing Multiple Regenerative Sites

Yu,

Chen,

Yan

et al. 2024

Adv Healthcare Materials

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“…This research provides new insight into using nanoparticles in medicine containing cerium and phytocompounds (geniposide and harpagoside) against protein aggregation for in vitro tests and AD models. Based on previous studies, CeO 2 -NPs have potent antioxidant and redox properties [34], and the obtained results indicated that they could be promising for the therapy of diseases where oxidative stress plays a critical role, such as neurological disorders. Thus, CeO 2 -NPs, by their powerful free radical scavenging ability, were employed as carriers to load geniposide and harpagoside for the treatment of AD.…”

Section: Discussionmentioning

confidence: 92%

Geniposide and Harpagoside Functionalized Cerium Oxide Nanoparticles as a Potential Neuroprotective

Pérez Gutiérrez,

Rodríguez-Serrano,

Laguna-Chimal

et al. 2024

IJMS

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Alzheimer’s disease is associated with protein aggregation, oxidative stress, and the role of acetylcholinesterase in the pathology of the disease. Previous investigations have demonstrated that geniposide and harpagoside protect the brain neurons, and cerium nanoparticles (CeO2 NPs) have potent redox and antioxidant properties. Thus, the effect of nanoparticles of Ce NPs and geniposide and harpagoside (GH/CeO2 NPs) on ameliorating AD pathogenesis was established on AlCl3-induced AD in mice and an aggregation proteins test in vitro. Findings of spectroscopy analysis have revealed that GH/CeO2 NPs are highly stable, nano-size, spherical in shape, amorphous nature, and a total encapsulation of GH in cerium. Treatments with CeO2 NPs, GH/CeO2 NPs, and donepezil used as positive control inhibit fibril formation and protein aggregation, protect structural modifications in the BSA-ribose system, have the ability to counteract Tau protein aggregation and amyloid-β1–42 aggregation under fibrillation condition, and are able to inhibit AChE and BuChE. While the GH/CeO2 NPs, treatment in AD induced by AlCl3 inhibited amyloid-β1–42, substantially enhanced the memory, the cognition coordination of movement in part AD pathogenesis may be alleviated through reducing amyloidogenic pathway and AChE and BuChE activities. The findings of this work provide important comprehension of the chemoprotective activities of iridoids combined with nanoparticles. This could be useful in the development of new therapeutic methods for the treatment of neurodegenerative diseases.

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“…Taking into account the unique redox properties and oxygen exchange on the nanoparticle surface, the cerium oxide nanoparticles show promising applications as antimicrobial, anticancer, anti-inflammatory, antidiabetic or antifungal agents, bioscaffolds or drug delivery vehicles [ 21 , 27 ]. The morphology, Ce 3+ /Ce 4+ surface ratio, oxygen vacancies, zeta potential and the nanoparticle microenvironment can modify the redox activity mechanism and the biomedical effects of the cerium oxide nanoparticles [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Tailoring the Structural and Optical Properties of Cerium Oxide Nanoparticles Prepared by an Ecofriendly Green Route Using Plant Extracts

Fifere,

Ardeleanu,

Doroftei

et al. 2024

IJMS

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The present study explores an environmentally friendly green approach to obtain cerium oxide nanoparticles via a biomediated route using Mellisa officinalis and Hypericum perforatum plant extracts as reducing agents. The as-prepared nanoparticles were studied for their structural and morphological characteristics using XRD diffractometry, scanning electron microscopy, Raman, fluorescence and electronic absorption spectra, and X-ray photoelectron spectroscopy (XPS). The XRD pattern has shown the centered fluorite crystal structure of cerium oxide nanoparticles with average crystallite size below 10 nm. These observations were in agreement with the STEM data. The cubic fluorite structure of the cerium oxide nanoparticles was confirmed by the vibrational mode around 462 cm−1 due to the Ce-08 unit. The optical band gap was estimated from UV-Vis reflectance spectra, which was found to decrease from 3.24 eV to 2.98 eV. A higher specific area was determined for the sample using M. officinalis aqueous extract. The EDX data indicated that only cerium and oxygen are present in the green synthesized nanoparticles.

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CeO2 nanoparticles improve prooxidant/antioxidant balance, life quality and survival of old male rats

Cited by 8 publications

References 69 publications

Enhancing Infected Diabetic Wound Healing through Multifunctional Nanocomposite‐Loaded Microneedle Patch: Inducing Multiple Regenerative Sites

Enhancing Infected Diabetic Wound Healing through Multifunctional Nanocomposite‐Loaded Microneedle Patch: Inducing Multiple Regenerative Sites

Geniposide and Harpagoside Functionalized Cerium Oxide Nanoparticles as a Potential Neuroprotective

Tailoring the Structural and Optical Properties of Cerium Oxide Nanoparticles Prepared by an Ecofriendly Green Route Using Plant Extracts

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