Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?

Luan, Yi; Li, Mingli; Zhao, Yi; Li, Qianqian; Jiang, Wen; Gao, Siqi; Yang, Yang

doi:10.1016/j.biopha.2021.112292

Cited by 11 publications

(11 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Breast cancer is an out-of-control proliferation of mammary gland epithelial cells due to a variety of carcinogenic factors [12,13]. The early stage of the disease is often manifested as breast lumps, nipple discharge, axillary lymph node enlargement and other symptoms, and the late stage can be manifested as the distant metastasis of cancer cells, multiple organ lesions and the direct threat to the patient's life [14,15]. According to the latest data from the International Agency for Research on Cancer (IARC) in 2018, breast cancer is the most common cancer among women worldwide, accounting for 24.2 % of all cancers, with 52.9 percent occurring in developing countries.…”

Section: Discussionmentioning

confidence: 99%

Sini San inhibits breast cancer cell migration and angiogenesis via the HIF 1 /VEGF pathway

Zhang¹,

Chen²,

Lv³

et al. 2023

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To investigate the effects of Sini San (SNS) on breast cancer (BC), and the mechanism of action.Methods: MDA-MB-231 and SK-BR-3 cells were used as breast cancer cell models. Cell viability, migration, and invasion were determined by CCK-8, Transwell and wound healing assays, respectively. SNS mechanism of action and its anti-cancer effect were investigated by network pharmacological analysis, and further verified by Immunoblot.Results: Sini San inhibited the proliferation of the breast cancer (BC) cells., and also suppressed the migration as well as the invasion of BC cells, and also restrained the angiogenesis of BC cells. In performing the network pharmacological analysis of Sini Powder in the treatment of BC, 337 drugdisease targets were obtained. PPI network was established through String, and GO and KEGG enrichment analysis was performed on the target sites. KEGG analysis showed that genes were enriched in HIF-1 and VEGF pathways.Conclusion: Sini San suppressed cell migration as well as angiogenesis via the HIF-1 /VEGF pathway

show abstract

Section: Discussionmentioning

confidence: 99%

Sini San inhibits breast cancer cell migration and angiogenesis via the HIF 1 /VEGF pathway

Zhang¹,

Chen²,

Lv³

et al. 2023

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…They play an important role in regulating many cellular processes during interphase, such as cell morphology and polarization; as well as during mitosis, such as spindle formation, chromosome segregation and cytokinesis ( 18 ). These intracellular organelles are regulated by a large variety of centrosome-associated proteins throughout the cell cycle ( 19 ) ( Figure 1 , Table 1 ). The complex process of centriole duplication and maturation is orchestrated by a number of proteins during various stages of the cell cycle ( Figures 1 - 4 ).…”

Section: Centrosomes and Their Associated Proteins During The Cell Cyclementioning

confidence: 99%

“…PLK1 also regulates NIMA-related-kinase 2 (NEK2), which participates in bipolar spindle assembly to promote mitotic entry as well as mediates centrosome separation during mitosis by interacting with Centrosomal NEK2-Associated Protein 1 (C-NAP1; also known as CEP250) ( 21 , 55 , 66 , 75 , 76 ) ( Figure 4 ). At this stage, the separating centrosomes form the poles of the mitotic spindle to facilitate chromosome segregation ( Figure 1 ) ( 19 ).…”

Section: Centrosomes and Their Associated Proteins During The Cell Cyclementioning

confidence: 99%

Centrosomes and associated proteins in pathogenesis and treatment of breast cancer

Athwal,

Kochiyanil,

Bhat

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

Breast cancer is the most prevalent malignancy among women worldwide. Despite significant advances in treatment, it remains one of the leading causes of female mortality. The inability to effectively treat advanced and/or treatment-resistant breast cancer demonstrates the need to develop novel treatment strategies and targeted therapies. Centrosomes and their associated proteins have been shown to play key roles in the pathogenesis of breast cancer and thus represent promising targets for drug and biomarker development. Centrosomes are fundamental cellular structures in the mammalian cell that are responsible for error-free execution of cell division. Centrosome amplification and aberrant expression of its associated proteins such as Polo-like kinases (PLKs), Aurora kinases (AURKs) and Cyclin-dependent kinases (CDKs) have been observed in various cancers, including breast cancer. These aberrations in breast cancer are thought to cause improper chromosomal segregation during mitosis, leading to chromosomal instability and uncontrolled cell division, allowing cancer cells to acquire new genetic changes that result in evasion of cell death and the promotion of tumor formation. Various chemical compounds developed against PLKs and AURKs have shown meaningful antitumorigenic effects in breast cancer cells in vitro and in vivo. The mechanism of action of these inhibitors is likely related to exacerbation of numerical genomic instability, such as aneuploidy or polyploidy. Furthermore, growing evidence demonstrates enhanced antitumorigenic effects when inhibitors specific to centrosome-associated proteins are used in combination with either radiation or chemotherapy drugs in breast cancer. This review focuses on the current knowledge regarding the roles of centrosome and centrosome-associated proteins in breast cancer pathogenesis and their utility as novel targets for breast cancer treatment.

show abstract

“…Centrosomes are microtubule-organizing centers in human cells that are required for mitotic spindle formation. Centrosome abnormalities in HPV-associated tumors cause mitotic defects and aneuploidy [ 26 ].…”

Section: Hpv Oncogenesismentioning

confidence: 99%

The complexity of human papilloma virus in cancers: a narrative review

Sofiani

Veisi

Rukerd

et al. 2023

Infect Agents Cancer

View full text Add to dashboard Cite

Among human tumorigenic viruses, the role of Human papillomavirus (HPV) has been proven as one of the most important oncoviruses that are associated with a large number of cancers. Most cancers of the genital area such cervical and anal cancer as are caused by HPV, and in many other cancers, such as colorectal, gastric, liver, esophageal, urinary bladder, and head and neck cancers, it is considered as one of the important risk factors. Our search was conducted for published researches between 2000 and 2022 by using several international databases including Scopus, PubMed, and Web of Science as well as Google scholar. We also evaluated additional evidence from relevant published articles. It has been demonstrated that HPV can promote tumorigenesis via focusing on genes, proteins, and signaling pathways, by using E6 and E7 oncoproteins and inhibiting two crucial tumor suppressors, P53 and Rb. The following study was performed to investigate different malignant cancers under the influence of HPV infection and changes in molecular factors caused by HPV infection.

show abstract

Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?

Cited by 11 publications

References 110 publications

Sini San inhibits breast cancer cell migration and angiogenesis via the HIF 1 /VEGF pathway

Sini San inhibits breast cancer cell migration and angiogenesis via the HIF 1 /VEGF pathway

Centrosomes and associated proteins in pathogenesis and treatment of breast cancer

The complexity of human papilloma virus in cancers: a narrative review

Contact Info

Product

Resources

About