Centriole migration during regeneration and normal development of olfactory epithelium

Mulvaney, Bruce D.; Heist, Herbert E.

doi:10.1016/s0022-5320(71)80157-0

Cited by 22 publications

(22 citation statements)

References 13 publications

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“…This is in general agreement with estimates for other mammals ( x lo4): pig, 6.2 (Gasser, 1956); rabbit, 12 (Allison and Warwick, 1949). 15 (Clark andWarwick, 1956), 12.6 (Mulvaney andHeist, 1971);andrat, 8.3 (Menco, 1980), 5-10 (Hinds andMcNelly, 1981). The surface density of supporting cells was estimated to be 2.3 x lo4 per mm2.…”

Section: Relative Densities Of Cell Types In the Mousesupporting

confidence: 88%

“…These cells would be in a range of different stages: quiescent basal cells, those undergoing division, and 'almost mature' cells. In the rabbit the number of 'almost mature' cells (those with a dendrite close to, but not through the epithelial surface) was -20% of the number of mature neurons (Mulvaney and Heist, 1971). If the same ratio is true for mouse, then about one-quarter of the cells we have called 'immature and basal cells' would actually be 'almost mature' receptor cells.…”

Section: Relative Densities Of Cell Types In the Mousementioning

confidence: 98%

“…Two probable requirements for this final maturation are the formation of synapses in the olfactory bulb (Hinds et al, 1984) and the penetration of the epithelial surface by the dendrites to form the olfactory knob (Breipohl et al, 1986). In the adult rabbit there is clear evidence for such a population of 'almost mature' cells; the number of dendrites just below the epithelial surface is 22% more than the number of dendritic knobs just above the surface (Mulvaney and Heist, 1971). In the adult salamander, immature receptor cells without an olfactory knob also comprise a large proportion of the cells in the epithelium (Mackay-Sim er al., 1988).…”

Section: Introductionmentioning

confidence: 99%

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On the Life Span of Olfactory Receptor Neurons

Mackay‐Sim

Kittel

1991

Eur J of Neuroscience

190

112

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The life span of olfactory receptor neurons was investigated after injection of a retrograde tracer into the olfactory bulb. Mice were injected unilaterally with colloidal gold conjugated with Concanavalin A and their olfactory epithelia were examined after 7, 14, 30, 60, and 90 days. Gold particles could be seen in the epithelia at all survival periods after silver intensification. There was no gold in the epithelia on the uninjected side. In order to test whether gold could be recycled within the epithelium upon the death of receptor neurons, the olfactory bulbs of some mice were ablated 4 days after colloidal gold injection. None of the receptor neurons in these epithelia contained gold at any survival period. To investigate whether gold was continuously available at the injection site, olfactory bulbs were examined by electron microscopy. By 7 days after injection all gold was sequestered intracellularly and was presumably unavailable for uptake by the olfactory axons. These results indicate that olfactory receptor neurons live for at least three times the commonly accepted life span of 30 days. A long life span challenges the widely held view that olfactory receptor neurons are regularly replaced.

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Section: Relative Densities Of Cell Types In the Mousesupporting

confidence: 88%

Section: Relative Densities Of Cell Types In the Mousementioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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On the Life Span of Olfactory Receptor Neurons

Mackay‐Sim

Kittel

1991

Eur J of Neuroscience

190

112

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“…Although there is much to be learned about the differentiation of olfactory dendrites, Heist and Mulvaney (1968) and Mulvaney and Heist (1971) certainly provided a first look at the process. In studies of differentiating neurons in the olfactory epithelium of rabbits, they presented evidence that centrioles replicate in the perikarya and migrate to the tips of differentiating dendritic processes.…”

Section: Microtubule Organizing Centersmentioning

confidence: 99%

Ultrastructural studies of microtubules and microtubule organizing centers of the vertebrate olfactory neuron

Burton

1992

Microscopy Res & Technique

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The olfactory neuron is specialized along its length into highly determined morphological regions. These regions include the dendritic cilia, dendritic vesicle, dendritic shaft proper, perikaryon, axon, zone of transition where the axon widens as it approaches its termination, and the axon terminal. Except for the zone of transition and the terminal, characteristic populations of microtubules occur in these compartments. In the olfactory vesicle, three discrete microtubule organizing centers (MTOCs) nucleate microtubules: the basal body, the lateral foot associated with the body, and dense masses of nearby material. Little is known about MTOCs elsewhere in the neuron, although the polarity of the axonal microtubules indicate that they originate at or near the perikaryon. An attempt is made to summarize what is known of the origin, structure, distribution, and function of microtubules in vertebrate olfactory neurons, which are useful model systems in which to study microtubules. Information about olfactory neuron microtubules may be applicable to neurons in general (e.g., the discovery that axons contain microtubules of uniform polarity was first made in the olfactory neuron) or to microtubules in other eukaryotic cells.

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“…Some olfactory sensory neurons were finalizing differentiation. In these, centrioles, located at various depths inside the cytoplasm, indicated migration of these structures to the luminal surface to become basal bodies (Mulvaney & Heist, 1971). The number of cilia on each olfactory sensory neuron seen in these sections ranged from 1 to 3.…”

Section: Resultsmentioning

confidence: 99%

Morphological and electrophysiological examination of olfactory sensory neurons during the early developmental prolarval stage of the sea lamprey Petromyzon marinus L

et al. 2005

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This study examined olfactory sensory neuron morphology and physiological responsiveness in newly hatched sea lamprey, Petromyzon marinus L. These prolarvae hatch shortly after neural tube formation, and stay within nests for approximately 18 days, before moving downstream to silty areas where they burrow, feed and pass to the larval stage. To explore the possibility that the olfactory system is functioning during this prolarval stage, morphological and physiological development of olfactory sensory neurons was examined. The nasal cavity contained an olfactory epithelium with ciliated olfactory sensory neurons. Axons formed aggregates in the basal portion of the olfactory epithelium and spanned the narrow distance between the olfactory epithelium and the brain. The presence of asymmetric synapses with agranular vesicles within fibers in the brain, adjacent to the olfactory epithelium suggests that there was synaptic connectivity between olfactory sensory axons and the brain. Neural recordings from the surface of the olfactory epithelium showed responses following the application of L-arginine, taurocholic acid, petromyzonol sulfate (a lamprey migratory pheromone), and water conditioned by conspecifics. These results suggest that lampreys may respond to olfactory sensory input during the prolarval stage.

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Centriole migration during regeneration and normal development of olfactory epithelium

Cited by 22 publications

References 13 publications

On the Life Span of Olfactory Receptor Neurons

On the Life Span of Olfactory Receptor Neurons

Ultrastructural studies of microtubules and microtubule organizing centers of the vertebrate olfactory neuron

Morphological and electrophysiological examination of olfactory sensory neurons during the early developmental prolarval stage of the sea lamprey Petromyzon marinus L

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