Centrifugal ultrafiltration preconcentration for studying the colloidal phase of a uranium-containing soil suspension

Maria, Emmanuelle; Faucher, Stéphane; Crançon, Pierre; Lespès, Gaëtane

doi:10.1016/j.chroma.2021.461957

Cited by 1 publication

(1 citation statement)

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“…Therefore, we developed a rapid, convenient, and low-cost method to screen optimal carriers for sampling hydrophobic compounds with the use of centrifugal ultrafiltration which is a membrane-based separation or concentration technique [ 16 , 17 ]. Doxorubicin was used as the model compound and its RR U (relative recoveries obtained from ultrafiltration) and RR M were compared when different types or concentrations of cyclodextrins were used as the carriers.…”

Section: Introductionmentioning

confidence: 99%

A rapid screening method to select microdialysis carriers for hydrophobic compounds

Wang

et al. 2021

PLoS ONE

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Microdialysis is a minimally invasive sampling technique which is widely applied in many fields including clinical studies. This technique usually has limitation on sampling hydrophobic compounds as aqueous solutions are commonly used as the perfusates. The relative recovery of hydrophobic compounds is often low and irreproducible because of the non-specific binding to microdialysis membranes or catheter tubing. Carriers such as cyclodextrins have been used to improve the recovery and consistency, however the identification of an optimal carrier can only be achieved after time-consuming and costly microdialysis experiments. We therefore developed a rapid, convenient, and low-cost method to identify the optimal carriers for sampling hydrophobic compounds with the use of centrifugal ultrafiltration. Doxorubicin was used as the model compound and its relative recoveries obtained from centrifugal ultrafiltration and from microdialysis were compared. The results show that the relative recoveries are highly correlated (correlation coefficient ≥ 0.9) between centrifugal ultrafiltration and microdialysis when different types or different concentrations of cyclodextrins were used as the carriers. In addition to doxorubicin, this method was further confirmed on three other drugs with different hydrophobicity. This method may facilitate and broaden the use of microdialysis perfusion on sampling or delivering hydrophobic substances in various applications.

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Section: Introductionmentioning

confidence: 99%

A rapid screening method to select microdialysis carriers for hydrophobic compounds

Wang

et al. 2021

PLoS ONE

View full text Add to dashboard Cite

show abstract

Centrifugal ultrafiltration preconcentration for studying the colloidal phase of a uranium-containing soil suspension

Cited by 1 publication

References 25 publications

A rapid screening method to select microdialysis carriers for hydrophobic compounds

A rapid screening method to select microdialysis carriers for hydrophobic compounds

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