Centrifugal Therapeutic Plasma Exchange in Pediatric Patients

Hans, Rekha; Tiewsoh, Karalanglin; Lamba, Divjot Singh; Sharawat, Indar Kumar; Prakash, Satya; Tripathi, Parmatma Prasad; Sankhyan, Naveen; Sharma, Ratti Ram; Marwaha, Neelam

doi:10.1007/s12098-020-03657-6

Cited by 2 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is similar to the studies by Haque et al, Weiss et al, and Hans et al where the majority of TPE was for ASFA category I, and the most common indication were TMA. 7 , 9 , 10 In contrast to our study results, ‘Sepsis/MODS’(ASFA category III) was the predominant indication in studies done by Keskin et al, Sik et al and Duyu et al 6 , 11 , 12 A significant portion, specifically two-thirds, of our study population exhibited non-renal indications for TPE. This trend is becoming more acknowledged, as noted by Margabandhu et al 13 …”

Section: Discussioncontrasting

confidence: 99%

“…We had three SAEs secondary to hypervolemia due to rinse back volume which is best avoided when blood priming is used and in conditions such as acute kidney injury, myocardial dysfunction, and acute lung injury that are known to be associated with complications secondary to volume overload. 10 The incidence of minor adverse events was 10.4% which is similar to that reported by Stegmayr B et al (10.3%). 19 …”

Section: Discussionsupporting

confidence: 87%

“… 7 , 14 Our results are in contradiction to the Hans et al study where SAE has occurred only in 1% of the cohort. 10 The discrepancy is likely due to the sicker cohort and the use of membrane apheresis in our study in contrast to their stable patients and the use of centrifugal apheresis. We had three SAEs secondary to hypervolemia due to rinse back volume which is best avoided when blood priming is used and in conditions such as acute kidney injury, myocardial dysfunction, and acute lung injury that are known to be associated with complications secondary to volume overload.…”

Section: Discussionmentioning

confidence: 66%

See 2 more Smart Citations

Scope, Safety, and Feasibility of Therapeutic Plasma Exchange in Pediatric Intensive Care Unit: A Single-center Experience

Ranjit,

Margabandhu,

Balasubramanian

et al. 2023

Indian Journal of Critical Care Medicine

View full text Add to dashboard Cite

A bstract Background Indications for therapeutic plasma exchange (TPE) in the pediatric intensive care unit (PICU) are expanding. We aimed to study the demographics, clinical indications, and outcomes of patients who have undergone TPE in our PICU. Materials and methods This is a retrospective study performed among children aged from 1 month to 16 years of age. Demographics, indications, therapeutic response, serious adverse events (SAE), PICU length of stay (LOS), and death during hospitalization were studied as outcome variables. Results Therapeutic plasma exchange was performed in 115 sessions on 24 patients for 12 different indications falling under various American Society for Apheresis (ASFA) categories. Therapeutic plasma exchange was performed on ten, four, and ten children for ASFA category I, II, and III indications, respectively. The most common indications were thrombotic microangiopathy (TMA) (8/24) and acute liver failure (ALF) (6/24). During those 115 sessions, a total of five serious adverse events (SAEs) occurred, accounting for 4.3% of the cases. Minor adverse events occurred in 12 sessions (10.4%). Therapeutic response was good in 17 patients (71%) including 5 patients who underwent standard volume TPE (SV-TPE) for ALF. Median PICU LOS was 9 (range 2–120) days. The mortality rate was 12.5% (3/24). Conclusion Therapeutic plasma exchange is effective in various clinical conditions involving various organ systems. It is an excellent therapeutic modality in children with ALF, irrespective of the exchange volume and TMA. However, SAEs do occur in the minority. How to cite this article Balasubramanian KK, Venkatachalapathy P, Margabandhu S, Natraj R, Sridaran VK, Lakshmanan C, et al . Scope, Safety, and Feasibility of Therapeutic Plasma Exchange in Pediatric Intensive Care Unit: A Single-center Experience. Indian J Crit Care Med 2023;27(10):766–770.

show abstract