Centrifugal Fibers to the Retina in the Rhesus Monkey

Noback, Charles R.; Fa, Mettler

doi:10.1159/000124424

Cited by 20 publications

(4 citation statements)

References 10 publications

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“…We cannot exclude the possibility that some GABA + fibers in the NFL are efferents. In primate retina, efferents have been reported in studies using reduced silver (Wolter, 1957(Wolter, , 1965Honrubia & Elliott, 1968, 1970Noback & Mettler, 1973;Reperant et al, 1981) and more definitively, HRP uptake from optic nerve injections (Perry et al, 1984), but these efferent axons all terminated in the INL or the IPL. We saw no indication of long GABA + fibers with terminal arborizations in the NFL.…”

Section: Discussionmentioning

confidence: 99%

GABA-Immunoreactive Synaptic Plexus in the Nerve Fiber Layer of Primate Retina

1989

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Synaptic contacts onto fibers and somata in the nerve fiber layer (NFL) and ganglion cell layer (GCL) of macaque and human retina were demonstrated at the electron microscopical (EM) level. Many presynaptic processes in monkey NFL are gamma aminobutyric acid (GABA) immunoreactive, using anti-GABA antiserum with an EM immunogold procedure. Immunocytochemistry at the light microscopic level revealed that many GABA-reactive cells in the GCL send branching processes into the NFL, forming a sparse synaptic plexus. The presence of long, unbranched GABA-reactive fibers running horizontally in the NFL and entering the optic nerve suggests that some ganglion cells may be GABAergic. GABA-reactive cells contributing to the plexus appear to be a new class of displaced amacrines that arborize in the NFL.

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Section: Discussionmentioning

confidence: 99%

GABA-Immunoreactive Synaptic Plexus in the Nerve Fiber Layer of Primate Retina

1989

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“…This effect of eye position is likely to be mediated by descending feedback connections. As descending connections affect the very earliest possible levels of auditory processing (for reviews, see Giard et al 2000;Simmons 2002) and also reach the retina (Brooke et al 1965;Labandeira-Garcia et al 1990;Noback and Mettler 1973), we may be only scratching the surface of eye-position effects in the brain.…”

Section: Discussionmentioning

confidence: 99%

Eye-Centered, Head-Centered, and Complex Coding of Visual and Auditory Targets in the Intraparietal Sulcus

Mullette-Gillman¹,

Cohen²,

Groh³

2005

Journal of Neurophysiology

210

251

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The integration of visual and auditory events is thought to require a joint representation of visual and auditory space in a common reference frame. We investigated the coding of visual and auditory space in the lateral and medial intraparietal areas (LIP, MIP) as a candidate for such a representation. We recorded the activity of 275 neurons in LIP and MIP of two monkeys while they performed saccades to a row of visual and auditory targets from three different eye positions. We found 45% of these neurons to be modulated by the locations of visual targets, 19% by auditory targets, and 9% by both visual and auditory targets. The reference frame for both visual and auditory receptive fields ranged along a continuum between eye- and head-centered reference frames with approximately 10% of auditory and 33% of visual neurons having receptive fields that were more consistent with an eye- than a head-centered frame of reference and 23 and 18% having receptive fields that were more consistent with a head- than an eye-centered frame of reference, leaving a large fraction of both visual and auditory response patterns inconsistent with both head- and eye-centered reference frames. The results were similar to the reference frame we have previously found for auditory stimuli in the inferior colliculus and core auditory cortex. The correspondence between the visual and auditory receptive fields of individual neurons was weak. Nevertheless, the visual and auditory responses were sufficiently well correlated that a simple one-layer network constructed to calculate target location from the activity of the neurons in our sample performed successfully for auditory targets even though the weights were fit based only on the visual responses. We interpret these results as suggesting that although the representations of space in areas LIP and MIP are not easily described within the conventional conceptual framework of reference frames, they nevertheless process visual and auditory spatial information in a similar fashion.

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“…Many anatomical studies have suggested the presence of centrifugal fibers in the optic nerve and retina in mammals, including humans (see Stell, 1972;Rodieck, 1973;Noback & Mettler, 1973;Wakakura & Ishikawa, 1982 for review). Although much of this evidence seems inadequate to prove the presence of the retinopetal system (see Brindley & Hamasaki, 1966), evidence obtained by silver-impregnation methods strongly suggests centrifugal fibers in the mammalian retina (e.g.…”

Section: Centrifugal Fibers In the Mammalian Retina: Anatomical And Pmentioning

confidence: 99%

Centrifugal pathways to the retina: Influence of the optic tectum

Uchiyama

1989

Vis Neurosci

119

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Two types of centrifugal pathways to the retina have been found in the vertebrates, according to the location of the cell bodies and presence or absence of connections with the optic tectum. One type is represented by the isthmo-optic nucleus (ION) of birds and, therefore, termed "ION-type" retinopetal system. The other type is termed "non-ION-type" retinopetal system. The ION-type retinopetal systems have been found in the cyclostomes, teleosts, reptiles, and birds. This review describes the anatomy and physiology of the ION-type retinopetal systems, mainly of birds and teleosts. On the basis of anatomical and physiological evidence cited in this review, the ION-type retinopetal systems can be regarded as the tectofugal pathways to the retina. The function of the ION-type retinopetal systems is discussed in detail, with special emphasis on their relation to the role of the tectum in mediating visuomotor behavior.

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Centrifugal Fibers to the Retina in the Rhesus Monkey

Cited by 20 publications

References 10 publications

GABA-Immunoreactive Synaptic Plexus in the Nerve Fiber Layer of Primate Retina

GABA-Immunoreactive Synaptic Plexus in the Nerve Fiber Layer of Primate Retina

Eye-Centered, Head-Centered, and Complex Coding of Visual and Auditory Targets in the Intraparietal Sulcus

Centrifugal pathways to the retina: Influence of the optic tectum

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