“…The centrifugal enhancement of infection has been described for human and murine cytomegaloviruses (Ho et al, 1993;Hodgkin et al, 1988;Hudson et al, 1976;Osborn and Walker, 1968), retroviruses (Bahnson et al, 1995;Chuck et al, 1996;Ho et al, 1993;Kotani et al, 1994;Pietroboni et al, 1989), bluetongue virus (Sundin and Mecham, 1989), adenoviruses (Nyberg-Hoffman et al, 1997), human herpesvirus type 6 (Pietroboni et al, 1989) and influenza A virus (Reading et al, 2001). This study evaluated the impact of centrifugation on HCV JFH1 infection of human hepatocytes.…”