Centre variation in incidence, indication and diagnosis of adult native renal biopsy in Scotland

McQuarrie, Emily P.; Mackinnon, Bruce; Young, Brian J.; Yeoman, Lindsay; Stewart, Graham; Fleming, Stewart; Robertson, Sue; Simpson, Keith; Fox, Jonathan G.; Geddes, Colin C.

doi:10.1093/ndt/gfn677

Cited by 49 publications

(45 citation statements)

References 16 publications

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“…Since 128,057,352 people resided in Japan in 2010, the estimated rate of renal biopsy was 140.6 to 164.0 per million population. This rate was higher than that in Romania [24], Spain [25], the Czech Republic [10], Denmark [26], and Scotland [27], was similar to that in France [28], and was lower than that in USA, Finland [29], and Australia [30].…”

Section: Discussion and Commentsmentioning

confidence: 59%

“…The incidence of renal biopsy and the incidence of biopsy-proven renal diseases such as IgAN and primary glomerular disease (except IgAN) could be surveyed in major renal centers in Japan in terms of the epidemiological aspects to work out appropriate countermeasures. In this aspect, the incidence of pediatric IgAN was reported to be 4.5 cases/year per 100,000 children under 15 years of age from 1983 to 1999 in Yonago City, Japan [31], although center variations in the country in terms of the incidence, indications and diagnosis of adult native renal biopsy have been reported [27]. Finally, a committee report of J-KDR including J-RBR in 2009, 2010 and their total was conducted.…”

Section: Discussion and Commentsmentioning

confidence: 99%

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Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010

et al. 2013

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123Clin Exp Nephrol (2013) 17:155-173 DOI 10.1007 nephritic syndrome (55.4 % and 50.0 % in 2009 and 2010, respectively), followed by nephrotic syndrome (22.4 % and 27.0 %); the most frequent pathological diagnosis as classified by the pathogenesis was IgA nephropathy (31.6 % and 30.4 %), followed by primary glomerular diseases (except IgA nephropathy) (27.2 % and 28.1 %). Among the primary glomerular diseases (except IgA nephropathy) in the patients with nephrotic syndrome, membranous nephropathy was the most common histopathology in 2009 (40.3 %) and minor glomerular abnormalities (50.0 %) were the most common in 2010 in native kidneys in the J-RBR. Five new secondary and longitudinal research studies by the J-KDR were started in 2009 and one was started in 2010.

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Section: Discussion and Commentsmentioning

confidence: 59%

Section: Discussion and Commentsmentioning

confidence: 99%

Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010

et al. 2013

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“…When we compared the biopsy distribution in NEP-TUNE with that in other pathology-based registries and cohorts in the southeastern United States, Saudi Arabia, Japan, and Scotland, NEPTUNE had an FSGS fraction similar to that in Saudi Arabia and Scotland (NEPTUNE, 32%; Saudi Arabia, 28%; Scotland, 28%), a greater fraction that that in Japan (6%), and a fraction lower than that in the southeastern United States (46%) (7)(8)(9)(10). MCD was more common in NEPTUNE that in the other registries (NEP-TUNE, 27%; southeastern United States, 13%; Saudi Arabia, 18%; Japan, 15%; Scotland, 18%).…”

Section: Discussionmentioning

confidence: 77%

Complete Remission in the Nephrotic Syndrome Study Network

Gipson

Troost

Lafayette

et al. 2016

Clinical Journal of the American Society of Nephrology

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Background and objectives This analysis from the Nephrotic Syndrome Study Network (NEPTUNE) assessed the phenotypic and pathology characteristics of proteinuric patients undergoing kidney biopsy and defined the frequency and factors associated with complete proteinuria remission (CRever).Design, setting, participants, & measurements We enrolled adults and children with proteinuria $0.5 g/d at the time of first clinically indicated renal biopsy at 21 sites in North America from April 2010 to June 2014 into a prospective cohort study. NEPTUNE central pathologists assigned participants to minimal-change disease (MCD), FSGS, membranous nephropathy, or other glomerulopathy cohorts. Outcome measures for this analysis were (1) CRever with urine protein-to-creatinine ratio (UPC) ,0.3 g/g with preserved native kidney function and (2) ESRD. Continuous variables are reported as median and interquartile range (IQR; 25th, 75th percentile). Cox proportional hazards modeling was used to assess factors associated with CRever.Results We enrolled 441 patients: 116 (27%) had MCD, 142 (32%) had FSGS, 66 (15%) had membranous nephropathy, and 117 (27%) had other glomerulopathy. The baseline UPC was 4.1 g/g (IQR, 1.9, 7.7) and the eGFR was 81 ml/min per 1.73 m 2 (IQR, 50, 105). Median duration of observation was 19 months (IQR,11, 30). CRever occurred in 46% of patients, and 4.6% progressed to ESRD. Multivariate analysis demonstrated that higher prebiopsy proteinuria (hazard ratio, 0.3; 95% confidence interval, 0.2 to 0.5) and pathology diagnosis (FSGS versus MCD; hazard ratio, 0.2; 95% confidence interval, 0.1 to 0.5) were inversely associated with CRever. The effect of immunosuppressive therapy on remission varied by pathology diagnosis.Conclusions In NEPTUNE, the high frequency of other pathology in proteinuric patients affirms the value of the diagnostic kidney biopsy. Clinical factors, including level of proteinuria before biopsy, pathology diagnosis, and immunosuppression, are associated with complete remission.

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“…Liberal biopsy practice in subjects with suspected nephropaties was noted in Finland and also in Sydney while patients in Toronto and Glasgow undergo renal biopsy in case of heavy proteinuria (> 1g/24 h) or renal failure [6]. These results correspond with higher biopsy rate in Finland (176 p.m.p./year) [14] and in Australia (215 p.m.p./year) [15] and lower biopsy rate in Scotland (126.3 p.m.p./year) [16,17]. The biopsy rate in the Czech Republic increased significantly from 44.1 p.m.p./year in 1994 to 58.2 p.m.p./year in 2001 and to 61.6 p.m.p./year in 2011 [4].…”

Section: Discussionmentioning

confidence: 99%

IgA Nephropathy in Czech Patients - Are We Able Reliably Predict the Outcome?

Maixnerová

Neprašová

Skibová

et al. 2014

Kidney Blood Press Res

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Background/Aims: The aim of our study was to retrospectively analyse data of 520 Czech patients with IgA nephropathy (IgAN) and to specify the risk factors affecting renal survival of IgAN patients. Methods: Cox proportional hazards regression model was used to evaluate the effects of different variables on renal survival during a median follow up of six years. McNemar´s test was used to analyse the progression of renal function according to Bartosik´s formula. Results: In our retrospective analysis of 520 Czech IgAN patients Cox proportional hazards regression model with five variables [hypertension, sex, GFR, proteinuria, age] was used. Significant regression coefficient was found for GFR, hypertension and proteinuria. Using stepwise algorithm GFR (OR = 3.09), hypertension (OR = 2.09) and proteinuria (OR = 1.97) were found as the most important factors for renal survival in our group of IgAN patients. Among patients with CKD 3 we found significantly better renal survival in patients with proteinuria < 1g/day compared to patients with higher proteinuria. We did not find the significant difference between predicted progression of renal function due to Bartosik´s formula and real progression of renal parametres assessed by GFR at the end of the follow up in our group of IgAN patients. Conclusion: Our retrospective study of 520 Czech IgAN patients confirmed GFR, hypertension and proteinuria as the most important factors affecting the prognosis of IgAN patients. We validated Toronto Bartosik´s formula to predict prognosis of IgAN patients.

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Centre variation in incidence, indication and diagnosis of adult native renal biopsy in Scotland

Cited by 49 publications

References 16 publications

Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010

Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010

Complete Remission in the Nephrotic Syndrome Study Network

IgA Nephropathy in Czech Patients - Are We Able Reliably Predict the Outcome?

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