Centre-surround organization of fast sensorimotor integration in human motor hand area

Dubbioso, Raffaele; Raffin, Estelle; Karabanov, Anke Ninija; Thielscher, Axel; Siebner, Hartwig R.

doi:10.1016/j.neuroimage.2017.06.063

Cited by 47 publications

(61 citation statements)

References 44 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, ADM muscle was located more medially (p=0.005) and superiorly (p=0.005) relative to the hotspot of the FDI muscle. This finding replicates our previous sulcus-aligned mapping studies, using a single line of targets placed at the caudal border of the precentral crown (27,33,34). Finally, ANOVA also revealed main effects of the two within-subject factors group (F(1,22)= 47.491, p<0.001) and coordinates (F(2,44)= 251.644, p< 0.001).…”

Section: Precentral Corticomotor Mappingsupporting

confidence: 89%

“…This is problematic because the angle at which the electrical current "hits" the precentral gyrus has strong impact on the TMS-induced electric field (32). These considerations prompted us to develop a sulcus-aligned TMS mapping procedure which adjusts the orientation of the TMS coil at each mapping site to the local curvature of the precentral gyrus (27,33,34). The procedure exploits the fact that the motor hand representation in the precentral gyrus can be readily identified on structural MRIs by its characteristic knob-like shape (35).…”

Section: Sulcus-aligned Tms Mapping Of the Motor Hand Knobmentioning

confidence: 99%

“…manually placed thirty-five stimulation sites: seven targets for five lines. As in our recent sulcus-aligned mapping studies (27,33,34), we chose a biphasic TMS pulse configuration. Biphasic pulse configurations are more efficient to stimulate the M1HAND than monophasic pulses (36).…”

Section: Sulcus-aligned Tms Mapping Of the Motor Hand Knobmentioning

confidence: 99%

See 2 more Smart Citations

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

Dubbioso

Madsen

Thielscher

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Transcranial magnetic stimulation (TMS) of the precentral hand knob can evoke motor evoked potentials (MEP) in contralateral hand muscles. Biophysical modelling points to the dorsal premotor cortex (PMd) in the superficial crown-lip region as primary site of TMS-induced neuronal excitation. Here, we used a sulcusaligned MRI-informed TMS mapping approach to determine the optimal site (hotspot) for evoking MEPs in the precentral hand knob. Individual precentral hotspot location varied along the rostro-caudal axis. Individuals with a more rostral location had longer MEP latencies. Spatiotemporal "hotspot rostrality" was associated with higher precentral myelin-related signals, stronger movement-related activation of PMd in the precentral crown, and higher temporal precision during paced finger tapping. Together, our multimodal mapping approach provides first-time evidence for behaviourally relevant, structural and functional phenotypic variation in the crown of human precentral motor hand knob. The results have important implications for physiological and interventional TMS studies targeting the precentral hand knob.

show abstract

Section: Precentral Corticomotor Mappingsupporting

confidence: 89%

Section: Sulcus-aligned Tms Mapping Of the Motor Hand Knobmentioning

confidence: 99%

See 1 more Smart Citation

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

Dubbioso

Madsen

Thielscher

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Complete voluntary muscle relaxation was monitored audio visually by high‐gain EMG (50μV/division). Trials contaminated with voluntary activity were discarded from the analysis …”

Section: Methodsmentioning

confidence: 99%

Neurophysiological Signatures of Motor Impairment in Patients with Rett Syndrome

Bernardo

Cobb

Coppola

et al. 2020

Annals of Neurology

Self Cite

View full text Add to dashboard Cite

Objective: Rett syndrome (RTT) is an X-linked dominant neurodevelopmental disorder due to pathogenic mutations in the MECP2 gene. Motor impairment constitutes the core diagnostic feature of RTT. Preclinical studies have consistently demonstrated alteration of excitation/inhibition (E/I) balance and aberrant synaptic plasticity at the cortical level. We aimed to understand neurobiological mechanisms underlying motor deficit by assessing in vivo synaptic plasticity and E/I balance in the primary motor cortex (M1). Methods: In 14 patients with typical RTT, 9 epilepsy control patients, and 11 healthy controls, we applied paired-pulse transcranial magnetic stimulation (TMS) protocols to evaluate the excitation index, a biomarker reflecting the contribution of inhibitory and facilitatory circuits in M1. Intermittent TMS-theta burst stimulation was used to probe long-term potentiation (LTP)-like plasticity in M1. Motor impairment, assessed by ad hoc clinical scales, was correlated with neurophysiological metrics. Results: RTT patients displayed a significant increase of the excitation index (p = 0.003), as demonstrated by the reduction of short-interval intracortical inhibition and increase of intracortical facilitation, suggesting a shift toward cortical excitation likely due to GABAergic dysfunction. Impairment of inhibitory circuits was also confirmed by the reduction of long-interval intracortical inhibition (p = 0.002). LTP-like plasticity in M1 was abolished (p = 0.008) and scaled with motor disability (all p = 0.003). Interpretation: TMS is a method that can be used to assess cortical motor function in RTT patients. Our findings support the introduction of TMS measures in clinical and research settings to monitor the progression of motor deficit and response to treatment. ANN NEUROL 2020;87:763-773 R ett syndrome (RTT) is the second most common cause of severe intellectual disability in females and is usually the result of dominantly acting mutations in the X-linked gene MECP2, which encodes methyl-CpG-binding protein 2 (MeCP2). 1 MeCP2 is expressed quite widely throughout the body, with notably high expression in postnatal neurons. 2,3 The currently used diagnostic criteria for RTT include an early neurologic regression occurring after an initially normal development that severely affects motor, cognitive, and communication skills. 4 Motor impairment constitutes the core diagnostic features of RTT, such as partial or complete loss of acquired purposeful hand skills and spoken language, the development of gait abnormalities, stereotypic hand movements, and the View this article online at wileyonlinelibrary.com.

show abstract

“…This protocol can provide information about latent sensorimotor interactions between body parts [26–29], and has been widely used to examine sensory interactions within the same body part. For example, hand muscle responses are strongly inhibited following stimulation of hand nerves or the skin on the fingertip [14,15,24,25,27,28,16–23], especially when the stimulus is given close to the target muscle [30], and topographic information can be preserved in the sensory-to-motor inhibitory pattern [31]. Similarly, stimulation of the shoulder area inhibits responses in the shoulder muscle infraspinatus [32], and stimulation of the dorsal surface of the foot inhibits responses in the leg muscle tibialis anterior [29].…”

Section: Introductionmentioning

confidence: 99%

Electrocutaneous stimulation to the face inhibits motor evoked potentials in the hand: face-hand interactions revealed by afferent inhibition

Ramalho

Moly

Raffin

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Reorganization of the sensorimotor cortex following amputation and other interventions has revealed large-scale plastic changes between the hand and face representations. To investigate whether hand-face interactions are also present in the normal state of the system we measured sensorimotor interactions between these two areas using an afferent inhibition transcranial magnetic stimulation (TMS) protocol in which the TMS motor evoked potential (MEP) is inhibited when it is preceded by an afferent stimulus. We hypothesized that if hand-face interactions exist in the normal state of the system then stimulation of the face would inhibit hand MEPs. In two separate experiments we delivered an electrocutaneous stimulus to either the right upper lip (Experiment 1) or right cheek (Experiment 2) and recorded muscular activity from the right first dorsal interosseous (FDI). Both lip and cheek stimulation inhibited FDI MEPs. To investigate the specificity of this effect we conducted two additional experiments in which cutaneous stimulation was applied to either the right forearm (Experiment 3) or right arm (Experiment 4). Neither forearm nor arm stimulation inhibited FDI MEPs. These data provide the first evidence for face-to-hand afferent inhibition and we suggest that the mechanisms underlying these sensorimotor interactions could contribute to face/hand interactions observed following sensorimotor reorganisation.

show abstract

Centre-surround organization of fast sensorimotor integration in human motor hand area

Cited by 47 publications

References 44 publications

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

Neurophysiological Signatures of Motor Impairment in Patients with Rett Syndrome

Electrocutaneous stimulation to the face inhibits motor evoked potentials in the hand: face-hand interactions revealed by afferent inhibition

Contact Info

Product

Resources

About