Centrapalus pauciflorus: Review of its Medicinal uses, Phytochemistry and Pharmacological Properties

Abstract

Centrapalus pauciflorus is a herbaceous plant that is used as a traditional medicine and a source of epoxidised oil. This study is aimed at providing a critical review of the pharmacological properties, phytochemistry and medicinal uses of C. pauciflorus. Documented information on the pharmacological properties, phytochemistry and medicinal uses of C. pauciflorus was collected from several online sources, which included Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as scientific publications, these, books, dissertations, book chapters and journal articles. This study showed that the leaves and epoxidised oil of C. pauciflorus are used as traditional medicines for external injury, wounds, diabetes, chest pains, eye infections, stomach problems and skin infections. Phytochemical compounds identified from the species include coumarins, essential oils, fatty acids, flavonol glycosides, phenolic acids, sterols, sesquiterpene lactones, triterpenoids, alkaloids, cardiac glycosides, carotenoids, flavonoids, polyuronoids, saponins, steroids, tannins and terpenoids. Pharmacological research revealed that C. pauciflorus extracts and compounds isolated from the species have analgesic, anti-dermatitis, antimicrobial, antiulcerogenic, hypoglycemic, insecticide, larvicidal and sedative activities. Centrapalus pauciflorus should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.

Pauciflorins A–E, Unexpected Chromone–Monoterpene-Derived Meroterpenoids from Centrapalus pauciflorus

“…11 C. pauciflorus has been used in traditional medicine to treat chest and stomach pain. 12 In a preliminary experiment, fractions obtained from the chloroform-soluble extract of C. pauciflorus were assayed against the human breast (MCF-7 and MDA-MB-231), cervical (HeLa), and ovarian (A2780) cancer cell lines for antiproliferative activity. As presented in Figure S1 in the Supporting Information , fraction 3 eluted with 60% MeOH from the polyamide column exhibited the most potent activity; so therefore this fraction was selected for isolation of the chemical constituents.…”