Centrally-mediated sensory information processing is impacted with increased alcohol consumption in college-aged individuals

Nguyen, Ruby H.N.; Gillen, Cody; Garbutt, James C.; Kampov-Polevoi, A. B.; Holden, Jameson K.; Francisco, Eric; Tommerdahl, Mark

doi:10.1016/j.brainres.2012.11.021

Cited by 16 publications

(12 citation statements)

References 66 publications

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“…We demonstrate their feasibility in healthy adults (HA) and typically developing children (TDC), a prerequisite for future clinical studies, and present normative results. We present these data in the context of previous work in the field (Puts et al, 2011; Tannan et al, 2007a, 2007b; Tommerdahl et al, 2008b; Zhang et al, 2011) (Lee et al, 2012; Nelson et al, 2012; Nguyen et al, 2013a, 2013b; Rai et al, 2012) to compare the performance of children and adults and to investigate patterns of performance. A priori, we would expect absolute levels of performance to differ between the HA and TDC but the relationships between related tasks to be preserved.…”

Section: Introductionmentioning

confidence: 99%

A vibrotactile behavioral battery for investigating somatosensory processing in children and adults

Puts

Edden

Wodka

et al. 2013

Journal of Neuroscience Methods

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The cortical dynamics of somatosensory processing can be investigated using vibrotactile psychophysics. It has been suggested that different vibrotactile paradigms target different cortical mechanisms, and a number of recent studies have established links between somatosensory cortical function and measurable aspects of behavior. The relationship between cortical mechanisms and sensory function is particularly relevant with respect to developmental disorders in which altered inhibitory processing has been postulated, such as in ASD and ADHD. In this study, a vibrotactile battery consisting of nine tasks (incorporating reaction time, detection threshold, and amplitude- and frequency discrimination) was applied to a cohort of healthy adults and a cohort of typically developing children to assess the feasibility of such a vibrotactile battery in both cohorts, and the performance between children and adults was compared. These results showed that children and adults were both able to perform these tasks with a similar performance, although the children were slightly less sensitive in frequency discrimination. Performance within different task-groups clustered together in adults, providing further evidence that these tasks tap into different cortical mechanisms, which is also discussed. This clustering was not observed in children, which may be potentially indicative of development and a greater variability. In conclusion, in this study, we showed that both children and adults were able to perform an extensive vibrotactile battery, and we showed the feasibility of applying this battery to other (e.g., neurodevelopmental) cohorts to probe different cortical mechanisms.

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Section: Introductionmentioning

confidence: 99%

A vibrotactile behavioral battery for investigating somatosensory processing in children and adults

Puts

Edden

Wodka

et al. 2013

Journal of Neuroscience Methods

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“…For example, numerous studies have reported on the effects of repetitive vibrotactile stimulation on the SI evoked cortical response, (Cannestra et al, 1998 ; Chiu et al, 2005 ; Simons et al, 2005 , 2007 ; Chiu, 2006 ) and from the findings reported in those studies, we predict that specific parametric changes in stimulus conditions could either improve or degrade sensory perceptual metrics. These perceptual findings, which proved to be robust in healthy controls (Tannan et al, 2005 , 2007b ; Tommerdahl et al, 2007a ; Francisco et al, 2008 , 2011 ; Zhang et al, 2011a ), have demonstrated sensitivity to a number of neurological conditions (Tommerdahl et al, 2007a ; Folger et al, 2008 ; Tannan et al, 2008 ; Francisco et al, 2011 ; Zhang et al, 2011b ; Nguyen et al, 2013a , b ). In other words, when a subject is neurologically compromised, the mechanisms involved in these biologically based metrics partially fail, and the neurologically compromised individual demonstrates metrics that significantly deviate from normative values.…”

Section: Introductionmentioning

confidence: 90%

Percept of the duration of a vibrotactile stimulus is altered by changing its amplitude

Francisco

Holden

Nguyen

et al. 2015

Front. Syst. Neurosci.

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There have been numerous studies conducted on time perception. However, very few of these have involved tactile stimuli to assess a subject’s capacity for duration discrimination. Previous optical imaging studies in non-human primates demonstrated that increasing the duration of a vibrotactile stimulus resulted in a consistently longer and more well defined evoked SI cortical response. Additionally, and perhaps more interestingly, increasing the amplitude of a vibrotactile stimulus not only evoked a larger magnitude optical intrinsic signal (OIS), but the return to baseline of the evoked response was much longer in duration for larger amplitude stimuli. This led the authors to hypothesize that the magnitude of a vibrotactile stimulus could influence the perception of its duration. In order to test this hypothesis, subjects were asked to compare two sets of vibrotactile stimuli. When vibrotactile stimuli differed only in duration, subjects typically had a difference limen (DL) of approximately 13%, and this followed Weber’s Law for standards between 500 and 1500 ms, as increasing the value of the standard yielded a proportional increase in DL. However, the percept of duration was impacted by variations in amplitude of the vibrotactile stimuli. Specifically, increasing the amplitude of the standard stimulus had the effect of increasing the DL, while increasing the amplitude of the test stimulus had the effect of decreasing the DL. A pilot study, conducted on individuals who were concussed, found that increasing the amplitude of the standard did not have an impact on the DL of this group of individuals. Since this effect did not parallel what was predicted from the optical imaging findings in somatosensory cortex of non-human primates, the authors suggest that this particular measure or observation could be sensitive to neuroinflammation and that neuron-glial interactions, impacted by concussion, could have the effect of ignoring, or not integrating, the increased amplitude.

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“…The design was based on the functionally equivalent CM4. The CM4 stimulator, described in detail in Holden et al, 2012, has been utilized to assess multiple sensory information processing characteristics in a diverse spectrum of human subject study [15,20,26,28,[32][33][34][35][36][37][38][39][40][41][42][43]. The prominent feature of these protocols, which have demonstrated significant sensitivity to alterations in CNS processing, is that they are independent of detection thresholds or skin sensitivity.…”

Section: Methodsmentioning

confidence: 99%

Response Time in Somatosensory Discrimination Tasks is Sensitive to Neurological Insult

OV¹,

EM²,

JK³

et al. 2019

NNB

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Background: A number of reports have demonstrated significant differences in human performance on diverse somatosensory-based discriminatory tasks dependent on the individual’s neurological status. For example, compromised neurological status has been shown to lead to poor performance on tactile-based tasks such as vibrotactile stimulus amplitude discrimination, frequency discrimination, temporal order judgement, timing perception, and reaction time, and these deficits have been observed across a diverse spectrum of neurological disorders. Results: In this report, response time of recently concussed individuals (1-3 days) was found to be significantly longer (~25%) than that of non-concussed individuals (i.e., controls) and individuals recovering from concussion (10+ days post-concussion). Additionally, a significant difference was found in response time on two different tasks. Timing perception, which is hypothesized to engage significantly more neural circuitry than amplitude discrimination, had a significantly longer average response time than amplitude discrimination. Conclusions: These findings strongly suggest that response time could be used as a discriminative measure when evaluating overall neurological health and/or cognitive function, and this is consistent with findings of other reports that examined speed-accuracy trade-offs on discrimination tasks.

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Centrally-mediated sensory information processing is impacted with increased alcohol consumption in college-aged individuals

Cited by 16 publications

References 66 publications

A vibrotactile behavioral battery for investigating somatosensory processing in children and adults

A vibrotactile behavioral battery for investigating somatosensory processing in children and adults

Percept of the duration of a vibrotactile stimulus is altered by changing its amplitude

Response Time in Somatosensory Discrimination Tasks is Sensitive to Neurological Insult

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