Centrally-mediated antinociceptive actions of GABAA receptor agonists in the rat spared nerve injury model of neuropathic pain

Synaptic Inhibition and Disinhibition in the Spinal Dorsal Horn

“…62,109 Furthermore, Schoffnegger et al 110 showed that the excitability of inhibitory neurons was not altered by nerve injury. Notwithstanding evidence that inhibitory neurons are intact and functioning properly, if reduced GABAergic transmission were the underlying cause of disinhibition, it stands to reason that replacing the lost transmitter 91,99,111,112 including through transplantation of GABAergic cells [113][114][115] would reverse the problem. Similarly, one could aim to enhance the inhibition produced by endogenously released GABA by applying allosteric modulators of GABA receptors (Section 9).…”

Pharmacological characterisation of place escape/avoidance behaviour in the rat chronic constriction injury model of neuropathic pain

“…Various studies have reported that both systemic and intrathecal administration of GABA A and GABA B receptor agonists are anti-nociceptive in animal models of peripheral nerve injury (Malan et al 2002;Rode et al 2005). In particular, Rode and colleagues have recently shown that systemically administered gaboxadol has marked antiallodynic effects in the rat spared nerve injury model of neuropathic pain at a dose (15 mg/kg) not associated with a parallel effect on motor disturbance (Rode et al 2005).…”

“…Based on these latter results, we chose to test lower doses of gaboxadol in the nociceptive tests using CCI rats since we needed to be confident that the rats were capable of moving between the light and dark sides of the test chamber. Ultimately, the doses used here may have been inadequate to attenuate escape/avoidance behaviour or mediate anti-nociception in CCI rats (Rode et al 2005).…”

Anxiolytic and Antiseizure Effects of Sida tiagii Bhandri

“…34) Pentylenetetrazole induces seizures in rodents by blocking the Cl − channel of Gamma amino butyric acid (subtype A) (GABA A ) receptors. It has been reported that GABAergic neurotransmission plays an important role in stress, anx-iety, 35) pain 36) and epilepsy. 37) The non significant results observed at higher doses may be attributed to the fact that the concentration of constituents in the plant with such biological activities could be attributed to their activity with antagonist compounds whose concentrations increase with doses.…”