Centrally infused atrial natriuretic polypeptide attenuates exaggerated salt appetite in spontaneously hypertensive rats.

Itoh, Hiroshi; Nakao, Kazuwa; Katsuura, Goro; Morii, Narito; Shiono, Satoshi; Sakamoto, Makoto; Sugawara, Akira; Yamada, Takayuki; Saito, Yoshihiko; Matsushita, Akira

doi:10.1161/01.res.59.3.342

Cited by 78 publications

(16 citation statements)

References 27 publications

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“…Furthermore, the number of glomerular ANP receptors is reduced during pregnancy in sheep [26]. An antagonisitic relation between ANP and renin angiotensin system is well-known [5,16]. Therefore, our pregnant data suggested reasonable results in consideration of the inhibitory action of renin release, the natriuretic property in ANP, and a reduced number of ANP receptors during pregnancy.…”

Section: Discussionsupporting

confidence: 58%

Synthesis and Secretion of A-Type Natriuretic Peptide in the Auricular Cardiocytes during Pregnancy and Lactation in Mouse.

Mifune

Suzuki

Honda

et al. 2000

The Journal of Veterinary Medical Science

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. A-type (atrial) natriuretic peptide (ANP) levels in the auricular cardiocytes and plasma were examined by immunohistochemistry, electron microscopy, and radioimmunoassay in pregnant and lactating mice. Additionally, the cardiocyte ANP mRNA expression was measured by the polymerase chain reaction method. ANP-immunoreactivity (IR) and the number of ANP-granules in the cardiocytes on the 18th day of gestation were greater than those in virgin controls, but the plasma ANP concentration decreased on the 18th day of gestation. On the day of delivery, ANP-IR and the number of ANP-granules in the cardiocytes were decreased compared to those during the pregnancy and to those in virgin controls, and then began to increase continually until the 15th day of lactation. Plasma ANP concentration after delivery was significantly higher than that during pregnancy, and than that in virgin controls, and continued to increase until the 15th day of lactation. Cardiocyte ANP mRNA expression was highest on the day of delivery compared to that in all the other times. In conclusion, these results suggested that the circulating systems of ANP during pregnancy and lactation were regulated differentially. nonpregnant, nonlactating controls. Moreover, we have examined the ANP mRNA levels in atrial cardiocytes to determine any change in the synthesis system of ANP during these periods. MATERIALS AND METHODS Animals:The heart and blood were obtained from 10 pregnant mice of the ICR strain (Jcl: ICR, CLEA Japan, Inc., Osaka, Japan) in each group on the 10th and 18th day of gestation, and from 10 lactating mice (same strain) in each group on the day of delivery, and on the 5th, 15th and 21st day after delivery. The day of insemination was defined as 0-day of gestation, and the day of delivery was regarded as 0-day of lactating. Normal vergin mice were used as control. All animals were kept in automatically controlled rooms (temperature: 24 ± 1°C; humidity: 55 ± 5%; automatic lighting: 6:00 a.m. to 8:00 p.m.) and fed with a pellet diet CE-2 (CLEA Japan, Inc., Osaka, Japan) and water ad libitum. These animals were sacrificed under sodium pentobarbital anesthesia (50 mg/kg, i. p.) and their hearts and blood were removed. All experiments were undertaken in accordance with Guide for Animal Experimentation, Kurume University.Immunohistochemistry: The left auricular tissue blocks were fixed in Zamboni's solution for 24 hr at 4°C. After washing with 0.15 M phosphate-buffered saline (PBS) at pH 7.3, they were dehydrated, embedded in paraffin and sectioned at 5 µm. Prior to immunohistochemical staining, the deparaffinized sections were incubated in absolute A-type (atrial) natriuretic peptide (ANP) is a circulating hormone with a wide range of biological effects, including natriuresis, diuresis and vasodilation, and it may play an important role in the regulation of blood pressure and body fluid homeostasis [5,12,29]. This peptide hormone is mainly produced and stored within secretory granules in the atrial cardiocytes [5,11,[21][22][23]. Dist...

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Section: Discussionsupporting

confidence: 58%

Synthesis and Secretion of A-Type Natriuretic Peptide in the Auricular Cardiocytes during Pregnancy and Lactation in Mouse.

Mifune

Suzuki

Honda

et al. 2000

The Journal of Veterinary Medical Science

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“…Previous studies using higher rates of i.c.v. ANF administration (100 or 500 ng/h) in SHRs, sufficient to attenuate salt appetite, also produced no change in blood pressure (Itoh, Nakao, Katsuura, Morii, Shiono, Sakamoto, Sugawara, Yamada, Saito, Matsushita & Imura, 1986).…”

Section: Discussionmentioning

confidence: 93%

Central and peripheral effects of the peptide ANF on renal function and blood pressure in hypertensive rats.

Al-Barazanji

Balment

1989

The Journal of Physiology

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SUMMARY1. The present study assesses renal and blood pressure effects of systemically and intracerebroventricularly (I.c.v.) administered atrial natriuretic factor (ANF) in anaesthetized New Zealand genetically hypertensive (NZGH) rats and their normotensive substrain (NZN).2. Plasma ANF concentration was significantly raised in NZGH compared with NZN animals. Intravenous ANF administration increased circulating ANF concentration to similar levels in NZGH and NZN rats. Plasma aldosterone concentrations were initially similar in normotensive and hypertensive animals and were reduced markedly by i.v. ANF administration in both groups.3. Peripheral administration of ANF produced a significant and sustained hypotension during the period of the hormone administration in NZGH animals, while arterial mean blood pressure (MBP) was not altered significantly in NZN rats. Central infusion of ANF produced no change in MBP in either NZGH or NZN animals. There was no detectable change in heart rate during central or peripheral administration of the hormone in either group.4. By comparison with animals maintained on hormone-free infusate, urine flow changed little over the 80 min period of i.v. ANF infusion in NZGH r"t,s but was markedly increased in NZN animals. Urinary sodium excretion was elei .-ted during ANF infusion in both NZGH and NZN animals. Central infusion of Al F produced a diuresis in NZN rats but a slight reduction in urine flow in NZGH animals, while sodium excretion was not affected in either group. 5. It appears from the present study that central and peripheral ANF effects on renal function and blood pressure differ in hypertensive and normotensive animals. These differences may in part reflect adjustments to long-term elevation in plasma ANF in hypertension and in part are possibly associated with disturbances in related endocrine mechanisms.

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“…13 This idea is supported by recent findings that centrally administered ANF inhibits angiotensin II-induced water drinking, 33 -M salt appetite, 35 vasopressin secretion, 36 -37 and corticotropin (ACTH) secretion 38 ; antagonizes the centrally, but not intravenously, angiotensin II-induced increase in blood pressure 39 ; and potentiates the hypotensive action of the angiotensin blocker saralasin in SHR. 40 In the subfornical organ of the brain, a much lower number of ANF receptors was found in SHR than in normotensive controls, 11 whereas the number of angiotensin II binding sites was higher in SHR, as compared with WKY.…”

Section: Discussionmentioning

confidence: 75%

Atrial natriuretic factor in specific brain areas of spontaneously hypertensive rats.

et al. 1988

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SUMMARY Atrial natriuretic peptldes (atrial natriuretic factor, ANF) are present in a great number of brain areas inside and outside of the blood-brain barrier. The pattern of distribution implies the involvement of ANF in different physiological functions, such as blood pressure regulation, electrolyte and fluid bomeostasis, and modulation of the neuroendocrine system. To further investigate a possible involvement of central ANF in spontaneous hypertension, we measured levels of ANF in 18 selected, microdissected brain areas of prehypertensive (4-week-old) and hypertensive (12-week-oM) spontaneously hypertensive rats (SHR) and their normotensive control, Wistar-Kyoto rats (WKY), by radioimmunoassay. ANF was significantly decreased hi seven brain areas in SHR at both ages investigated; the most pronounced decreases were found in the subfornical organ, hi the perifornkal and periventricular hypothalamic nuclei, and hi the medial preoptic nucleus. In addition, in young SHR ANF was significantly decreased in the organum vascutosum laminae terminalls and increased hi the median eminence. After the development of hypertension, a significant decrease of ANF could be detected hi four more brain areas (bed nucleus of the stria terminalis, paraventrkular and arcuate nuclei, dorsal raphe nucleus) of SHR, as compared with normotensive controls, and the increase hi the median eminence was no longer detectable. These results suggest a role for ANF hi genetk hypertension and the specific importance of certain brain regions. (Hypertension 12: 519-524, 1988) KEY WORDS • atrial natriuretic factor • brain • hypertension • spontaneously hypertensive ratsA TRIAL natriuretic peptides (atrial natriuretic / A factor, ANF) were first described in the JL A. mammalian cardiac atrium, where they are released into the general circulation to take part in the regulation of fluid homeostasis and blood pressure by acting on the kidneys, the adrenals, and the blood vessels.1 In addition to the peripheral actions of ANF, certain effects of circulating ANF may be centrally mediated, since binding sites for ANF have been localized in specific brain areas that lack a blood-brain barrier.2 -4 Furthermore, several lines of evidence indicate the existence of brain-born ANF. Immunohistochemical studies have demonstrated ANF-like material in neuronal perikarya, fibers, and terminals throughout the central nervous system,

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Centrally infused atrial natriuretic polypeptide attenuates exaggerated salt appetite in spontaneously hypertensive rats.

Abstract: spontaneously hypertensive rats.Centrally infused atrial natriuretic polypeptide attenuates exaggerated salt appetite in

Cited by 78 publications

References 27 publications

Synthesis and Secretion of A-Type Natriuretic Peptide in the Auricular Cardiocytes during Pregnancy and Lactation in Mouse.

Synthesis and Secretion of A-Type Natriuretic Peptide in the Auricular Cardiocytes during Pregnancy and Lactation in Mouse.

Central and peripheral effects of the peptide ANF on renal function and blood pressure in hypertensive rats.

Atrial natriuretic factor in specific brain areas of spontaneously hypertensive rats.

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