Centrally Acting Emetic Agents IV: Synthesis and Chromatographic Methods for Certain Nornuciferine Derivatives

Magnoflorine and N,N-Dimethyllindcarpine

“…There is ample precedence in the literature for selective O-demethylation of the most hindered methoxy group. A close analog to our reaction is the selective removal of the methoxyl at C-l in nornuciferine (8).…”

Potential psychotomimetics. 2. Rigid analogs of 2,5-dimethoxy-4-methylphenylisopropylamine (DOM, STP)

“…3-(2,5-Dimethoxy-4-methylphenyl)propionic Acid (23). A mixture of 31 g (0.139 mol) of 22, 1.5 g of 10% Pd/C, and 200 ml of absolute EtOH was hydrogenated at 50 psi for 1 hr.…”