Central μ opioid receptor mechanisms modulate mustard oil-evoked jaw muscle activity

Tambeli, Cláudia Herrera; Seo, Kenji; Sessle, Barry J.; Hu, James W.

doi:10.1016/s0006-8993(01)02742-1

Cited by 22 publications

(15 citation statements)

References 14 publications

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“…In fact, an increase in head withdrawal threshold was observed following injection of pH 3.0 saline into the masseter muscle. This may be analogous to the antinociceptive effect reported following mustard oil injection into the jaw joint and mediated via μ opioids (Tambeli et al, 2001). Our findings on CFA-induced craniofacial muscle inflammation extends our previous reports (Ambalavanar et al, 2006a;Ambalavanar et al, 2006c).…”

Section: Discussionsupporting

confidence: 58%

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Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression

Ambalavanar

Yallampalli

et al. 2007

Neuroscience

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Craniofacial muscle pain including muscular temporomandibular disorders accounts for a substantial portion of all pain perceived in the head and neck region. In spite of its high clinical prevalence, the mechanisms of chronic craniofacial muscle pain are not well understood. Injection of acidic saline into rodent hindlimb muscles produces pathologies which resemble muscular pathologies in chronic pain patients. Here we investigated whether analogous transformations occur following repeated injections of acidic saline into the rat masseter muscle. Injection of acidic saline (pH 4) into the masseter muscle transiently lowered intramuscular pH to levels comparable to those reported for rodent hindlimb muscles. Nevertheless, repeated unilateral or bilateral injections of acidic saline (pH 4) into the masseter muscle failed to alter nociceptive behavioral responses as occurs in the hindlimb. Changing the pH of injected saline to pH 3.0 or 5.0 also did not evoke nocifensive behavior. ASIC3 receptors, which are implicated in transformations following acidification of hindlimb muscles, were found on trigeminal ganglion muscle afferent neurons via combined neuronal tracing and immunocytochemistry. In contrast to the acidic saline, injection of complete Freund's adjuvant (CFA) into the masseter muscle induced mechanical allodynia for three weeks, thermal hyperalgesia for one week and an increase in the number of CGRP-immunoreactive muscle afferent neurons in the trigeminal ganglion. Although pH may alter CGRP release in primary afferent neurons, the number of CGRP-muscle afferent neurons did not change following intramuscular injection of acidic saline. Further, there was no change in ganglionic iCGRP levels at one, four or twelve days after intramuscular injection of acidic saline. While these findings extend our earlier reports that CFAinduced muscle inflammation results in behavioral and neuropeptide changes they further suggest that intramuscular acidification in craniofacial muscle evokes different responses than in hindlimb muscle and imply that disparate proton sensing mechanisms underlie these discrepancies. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeuroscience. Author manuscript; available in PMC 2008 November 9. Published in final edited form as:Neuroscience. 2007 November 9; 149(3): 650-659. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptFifteen percent of the American population suffers from chronic musculoskeletal pain, placing a substantial burden on the health care system (Magni et al., 1993;...

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Section: Discussionsupporting

confidence: 58%

Section: Discussionsupporting

confidence: 58%

Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression

Ambalavanar

Yallampalli

et al. 2007

Neuroscience

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“…However, a ceiling effect on neuronal activation by intense noxious chemical stimulation may override MOR-mediated endogenous inhibition and preclude the identification of a potential disinhibition component in MOR Ϫ/Ϫ mice. In fact, MOR-mediated inhibition of neuronal excitability was revealed after initial extensive noxious drive faded: naloxone (intrathecally or intravenously) and CTOP (intrathecally) significantly rekindle the mustard oil-induced increase in electromyographic activity (Yu et al, 1994;Tambeli et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Windup in Dorsal Horn Neurons Is Modulated by Endogenous Spinal μ-Opioid Mechanisms

Guan¹,

Borzan²,

Meyer³

et al. 2006

J. Neurosci.

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“…Previous studies have also reported prolonged effects of noxious stimuli on spinal sensorimotor system excitability that may last several hours after recovery from pain (e.g., Henderson et al 2006;Hoheisel and Mense 1989;Le Pera et al 2000Matre et al 1998;Wall and Woolf 1984). In the trigeminal system, evidence for a central inhibitory effect induced by noxious stimulation of deep tissues has been demonstrated (Dubner and Ren 2004;Tambeli et al 2001;Yu et al 1994) that might explain in part the decrease in MI excitability.…”

Section: Mechanisms Of Increased Thresholdsmentioning

confidence: 99%

Noxious Lingual Stimulation Influences the Excitability of the Face Primary Motor Cerebral Cortex (Face MI) in the Rat

Adachi

Murray²,

Lee³

et al. 2008

Journal of Neurophysiology

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Adachi K, Murray GM, Lee J-C, Sessle BJ. Noxious lingual stimulation influences the excitability of the face primary motor cerebral cortex (face MI) in the rat. J Neurophysiol 100: 1234 -1244. First published July 2, 2008 doi:10.1152/jn.90609.2008. The mechanisms whereby orofacial pain affects motor function are poorly understood. The aims were to determine whether 1) lingual algesic chemical stimulation affected face primary motor cerebral cortex (face MI) excitability defined by intracortical microstimulation (ICMS); and 2) any such effects were limited to the motor efferent MI zones driving muscles in the vicinity of the noxious stimulus. Ketamine-anesthetized Sprague-Dawley male rats were implanted with electromyographic (EMG) electrodes into anterior digastric, masseter, and genioglossus muscles. In 38 rats, three microelectrodes were located in left face MI at ICMS-defined sites for evoking digastric and/or genioglossus responses. ICMS thresholds for evoking EMG activity from each site were determined every 15 min for 1 h, then the right anterior tongue was infused (20 l, 120 l/h) with glutamate (1.0 M, n ϭ 18) or isotonic saline (n ϭ 7). Subsequently, ICMS thresholds were determined every 15 min for 4 h. In intact control rats (n ϭ 13), ICMS thresholds were recorded over 5 h. Only left and right genioglossus ICMS thresholds were significantly increased (Յ350%) in the glutamate infusion group compared with intact and isotonic saline groups (P Ͻ 0.05). These dramatic effects of glutamate on ICMS-evoked genioglossus activity contrast with its weak effects only on right genioglossus activity evoked from the internal capsule or hypoglossal nucleus. This is the first documentation that intraoral noxious stimulation results in prolonged neuroplastic changes manifested as a decrease in face MI excitability. These changes appear to occur predominantly in those parts of face MI that provide motor output to the orofacial region receiving the noxious stimulation.

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Central μ opioid receptor mechanisms modulate mustard oil-evoked jaw muscle activity

Cited by 22 publications

References 14 publications

Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression

Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression

Windup in Dorsal Horn Neurons Is Modulated by Endogenous Spinal μ-Opioid Mechanisms

Noxious Lingual Stimulation Influences the Excitability of the Face Primary Motor Cerebral Cortex (Face MI) in the Rat

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