Central versus peripheral effects of bombesin on the release of gastrointestinal hormones in dogs

Abstract

This study compared the effects of bombesin given intracerebroventricularly and intravenously on circulating levels of gastrin, pancreatic polypeptide (PP), and cholecystokinin (CCK-33). Bilateral cannulas were implanted permanently into the lateral cerebral ventricles of five dogs. An intravenous (IV) bolus injection of bombesin (0.25 microgram/kg) significantly elevated circulating levels of gastrin, PP, and CCK-33. Vagotomy inhibited the release of PP that was induced by IV bombesin, but vagotomy did not affect gastrin and CCK-33 responses. Intracerebroventricular injection of bombesin (5.0 micrograms) significantly elevated circulating gastrin levels but did not affect circulating levels of CCK-33 and PP. Vagotomy did not alter gastrin release induced by intracerebroventricular injection of bombesin.

Participación del sistema nervioso y del tracto gastrointestinal en la homeostasis energética

“…Bombesina. Este péptido de 14 aminoácidos sintetizado en el tracto gastrointestinal y el SNC presenta acciones similares a la CCK, ya que inhibe el apetito estimulando la síntesis y liberación de otros péptidos anorexigénicos como la CCK y la gastrina 101 . Además existen estudios que sugieren que la bombesina disminuye el apetito y el coeficiente respiratorio y estimula la vía de HHA a través de neuronas de CRH 102 .…”

Circulating markers for endocrine tumours of the gastroenteropancreatic tract

“…GRP is released in response to protein in the stomach. GRP stimulates the release of gastrin, 184 which in turn stimulates the ECL cells to produce histamine, which in turn stimulates the parietal cells to produce acid. GRP also activates inhibitory pathways involved in the regulation of gastric acid secretion, 185 thus playing a major role in the mediation of meal-stimulated acid secretion.…”