Central Versus Paracentral Endothelial Cell Density Values in Relation to Duration of Soft Contact Lens Wear

Abstract

In morphometry of the corneal endothelium away from central sites, the history of contact lens wear must be considered.

Further analysis of assessments of the coefficient of variation of corneal endothelial cell areas from specular microscopic images

“…In line with earlier conclusions, 35,36 it seems unlikely that an estimate of the COV from a single image can serve as a useful measure of the composition of the corneal endothelial cell layer, or as a reliable measure of changes after contact lens wear or surgery. One approach which has been applied to light microscopic images of stored corneas has been to use more than one image of the cell layer taken at slightly different locations, 29,40 although this approach might be questionable if there were substantial and predictable location‐dependent differences in the corneal endothelium 41 . While further studies to try to ascertain the reasons for the apparent dependence of the COV on the average cell area could be useful, further details of which cells are more likely to change (or stay the same) would seem to be a more logical goal for future research.…”

Endothelial cell redistribution

“…The theory of Wiffen et al 22 has been subsequently confirmed by Doughty and Aakre, 23 who observed a mean central and mid-peripheral endothelial cell density of 2,747 and 2,954 cells/mm 2 , respectively, among 104 myopic contact lens wearers. They noted a net ratio of midperipheral endothelial cell density of 1.0768 : 1 (p < 0.001).…”