Warren and Stead's (1) contention that disturbed renal function secondary to a diminished cardiac output is responsible for the following series of events-salt and water retention, increased blood and extracellular fluid volume, rise in venous pressure, edema-seemed to offer a rational explanation for some of the clinically observed phenomena. We therefore initiated a series of studies on patients with chronic congestive heart failure, using the clearance techniques of Smith and associates (2), in order to evaluate the relationship between the decreased sodium excretion in heart failure (3, 4) and renal blood flow, to determine the nature of the disturbance in renal function and the relationship, if any, between the altered renal dynamics and sodium retention. We later attempted to define some of the variables involved in the tubular transfer system for sodium as it obtains in the normal and in the cardiac patient. Since our studies began, Merrill (5) reported that the renal plasma flow was reduced to as little as 20 per cent and the filtration rate to 33 per cent of normal in chronic congestive failure. We have been able to confirm his findings of a decreased sodium excretion rate due to a diminished load presented to the tubules for reabsorption, and not to enhanced tubular reabsorption as suggested by earlier workers (3).
EXPERIMENTAL PROCEDUREPatients with advanced chronic congestive failure due predominantly to rheumatic heart disease were the subjects. All had variable amounts of edema at rest. Members of the resident house staff and patients without heart failure or renal disease served as controls.The subjects were brought to the laboratory in a postabsorptive state. Each patient was given 300 to 600 cc. of water about 30 to 60 minutes before the test period.' This study was aided by a grant from the Martha M. Hall Foundation and the Committee on Scientific Research of the American Medical Association.2 Martha M. Hall Foundation Fellow in Medicine.Five controls were maintained on a special cardiac saltpoor diet (about 1.3 grams of sodium chloride daily), for 4 to 5 days before the studies were made. Most of the patients with congestive heart failure were maintained on the same diet (strict metabolic control was not attempted) and, in addition, all were taking digitalis.