Central Venous Catheter-related Complications in Patients with Hematological Malignancies: A Retrospective Analysis of Risk Factors and Prophylactic Measures

Cortelezzi, Agostino; Fracchiolla, Nicola; Maisonneuve, Patrick; Moia, Marco; Luchesini, C.; Ranzi, M. L.; Monni, P.; Pasquini, Maria Cristina; Lambertenghi‐Deliliers, G.

doi:10.1080/1042819031000103980

Cited by 50 publications

(33 citation statements)

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“…And they are easy to insert, and associated to a low rate of early and late complications compared to conventional percutaneous method. Furthermore, PICCs are also easy to remove and less expensive than some other devices 4, 5 . However, PICCs have their own risks, such as infection, phlebitis and thrombosis 6 .…”

Section: Introductionmentioning

confidence: 99%

Nomogram predicted risk of peripherally inserted central catheter related thrombosis

Hao

Xie

Zhou

et al. 2017

Sci Rep

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The use of peripherally inserted central catheters (PICCs) is increasing rapidly worldwide. A number of patient-related, clinical-related and device-related characteristics might be risk factors for PICC-related thrombosis. We retrospectively reviewed a database of 320 consecutive patients who underwent PICC insertion between December 2014 and December 2015 at the First Affiliated Hospital of Xi’an Jiaotong University to explore the potential associations between risk factors and PICC-associated thrombosis. A novel nomogram for predicting risk was developed based on the data. The nomogram prediction model included ten risk factors that were derived from different relevant estimates. The nomogram prediction model showed good discriminatory power (Harrell’s C-index, 0.709) and a high degree of similarity to actual thrombosis occurring after calibration. Furthermore, principal component analysis was performed to identify the factors that most influence PICC-related thrombosis. Our novel nomogram thrombosis risk prediction model was accurate in predicting PICC-related thrombosis. Karnofsky performance scores, D-dimer and blood platelet levels and previous chemotherapy were principal components. Our findings might help clinicians predict thrombosis risk in individual patients, select proper therapeutic strategies and optimize the timing of anticoagulation therapy.

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Section: Introductionmentioning

confidence: 99%

Nomogram predicted risk of peripherally inserted central catheter related thrombosis

Hao

Xie

Zhou

et al. 2017

Sci Rep

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“…Insertion-related complications have dramatically decreased since the use of ultrasound guidance (USG), although one report described negative effects of USG (2). Major complications related to CVCs include infection and thrombosis (3, 4). Various management strategies have been recommended to prevent and treat infection and thrombosis (5), and CVC outcomes have improved considerably.…”

Section: Introductionmentioning

confidence: 99%

Safety and Effectiveness of Central Venous Catheterization in Patients with Cancer: Prospective Observational Study

et al. 2010

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This study investigated the safety and effectiveness of each type of central venous catheters (CVC) in patients with cancer. We prospectively enrolled patients with cancer who underwent catherization involving a subclavian venous catheter (SVC), peripherally inserted central venous catheter (PICC), or chemo-port (CP) in our department. From March 2007 to March 2009, 116 patients underwent 179 episodes of catherization. A SVC was inserted most frequently (46.4%). Fifty-four complications occurred (30.1%): infection in 23 cases, malpositioning or migration of the tip in 18 cases, thrombosis in eight cases, and bleeding in five cases. Malpositioning or migration of the tip occurred more frequently with a PICC (P<0.001); infection occurred more often with a tunneled catheter (P=0.028) and was observed more often in young patients (P=0.023). The catheter life span was longer for patients with solid cancer (P=0.002) than for those with hematologic cancer, with a CP (P<0.001) than a PICC or SVC, and for an indwelling catheter with image guidance (P=0.014) than a blind procedure. In conclusion, CP is an effective tool for long term use and the fixation of tip is important for the management of PICC.

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“…All of the counts were within the normal range. This finding may have occurred because the thrombosis rate is not related to the platelet count [30, 31]. …”

Section: Discussionmentioning

confidence: 99%

High risk of deep vein thrombosis associated with peripherally inserted central catheters in lymphoma

Huang

Xia

et al. 2016

Oncotarget

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Peripherally inserted central venous catheters (PICCs) are widely used in cancer patients. Although PICC is a convenient tool, its use is associated with an obvious increase in the incidence of venous thrombosis. The risk factors for deep vein thrombosis associated with the use of PICCs in cancer patients are largely unexplored. This study aimed to investigate the incidence of PICC-associated thrombosis in lymphoma compared with its incidences in other types of cancer. A total of 8028 adult cancer patients inserted with PICC between June 2007 and June 2015 were included in this study. A total of 249 of the 8028 included patients (3.1%) inserted with PICC developed upper extremity deep vein thrombosis (PICC-UEDVT). Patients with lymphoma were more likely to have PICC-UEDVT than those with other types of malignancies (7.1% vs. 2.80%; P < 0.001). Logistic analysis revealed that a lymphoma diagnosis was a risk factor for UEDVT in cancer patients inserted with PICC (OR: 3.849, 95% CI: 2.334–6.347). Patients with lymphoma may be more predisposed to developing PICC-UEDVT than those with other types of malignancies. Identifying the mechanism underlying the relationship between PICC-UEDVT and lymphoma requires further study.

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Central Venous Catheter-related Complications in Patients with Hematological Malignancies: A Retrospective Analysis of Risk Factors and Prophylactic Measures

Cited by 50 publications

References 0 publications

Nomogram predicted risk of peripherally inserted central catheter related thrombosis

Nomogram predicted risk of peripherally inserted central catheter related thrombosis

Safety and Effectiveness of Central Venous Catheterization in Patients with Cancer: Prospective Observational Study

High risk of deep vein thrombosis associated with peripherally inserted central catheters in lymphoma

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