Central Sympathetic Inhibition Augments Sleep-Related Ultradian Rhythm of Parasympathetic Tone in Patients With Chronic Heart Failure

Yamazaki, Takao; Asanoi, Hidetsugu; Ueno, Hiroshi; Yamada, Katsushi; Takagawa, Junya; Kameyama, Tomoki; Hirai, Tadakazu; Ishizaka, Shigeaki; Nozawa, Takashi; Inoue, Hiroshi

doi:10.1253/circj.69.1052

Cited by 13 publications

(5 citation statements)

References 31 publications

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“…15,16 HRV obtained from Holter monitoring as indices of ANA is known to be reproducible and reliable measure. 21,[23][24][25] Longitudinal studies are expected to show the features of age-related change more precisely and in more detail than cross-sectional studies, especially in a small population. Thus, to characterize the age-related changes of ANA in elderly patients, we analyzed the longitudinal age-related changes in HR, HRV, and their circadian rhythms over 15 years in 15 healthy elderly patients at a mean age of 70 years, and assessed the age-related changes in the dynamics of ANA in the morning.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Follow-up of the Circadian Rhythm of Heart Rate and Heart Rate Variability in Healthy Elderly Patients

Tasaki

Serita

Ueyama

et al. 2006

Circ J

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Section: Discussionmentioning

confidence: 99%

Long-Term Follow-up of the Circadian Rhythm of Heart Rate and Heart Rate Variability in Healthy Elderly Patients

Tasaki

Serita

Ueyama

et al. 2006

Circ J

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“…3 It has already been reported that central sympathetic inhibition by an α2-adrenergic agonist, guanfacine, augmented the sleep-related ultradian rhythm of parasympathetic tone in patients with chronic heart failure. 4 Although α2-adrenergic agonists are widely recognized as inducing a vagaldominant condition through the suppression of sympathetic nerve, there is little direct evidence that they directly increase cardiac vagal nerve activity, because such activity has been assessed only by indirect methods, such as heart rate variability, in most studies. 5 Vanoli et al 6 reported that vagal stimulation after an acute ischemic episode effectively prevented ventricular fibrillation in dogs.…”

mentioning

confidence: 99%

Medetomidine, an .ALPHA.2-Adrenergic Agonist, Activates Cardiac Vagal Nerve Through Modulation of Baroreflex Control

Shimizu¹,

Akiyama

Kawada³

et al. 2012

Circ J

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“…Reports suggest that almost 40% higher incidences of myocardial infarction, stroke, sudden cardiac death, conduction blocks etc occur during REM sleep [8,34]. Central sympathetic inhibition with pharmacological agents is shown to re-establish the sleep quality and autonomic modulations [35]. Therefore, effective buffering of sympathetic surges during REM sleep is one of the prerequisite towards ensuring cardio protection and quality sleep.…”

Section: Discussionmentioning

confidence: 99%

Vipassana Meditation Practices Enhance the Parasympathetic Activity during Sleep: a Case-Control Study of Heart Rate Variability across Sleep Cycles

Nagendra¹,

Sulekha²,

Sasidharan³

et al. 2017

IJCAM

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Background: Sleep state related cardiac autonomic modulations are important for proper cardiovascular functions and to maintain homeostasis during sleep. The present study evaluates the efficacy of Vipassana meditation on cardio autonomic dynamicity across sleep cycles during sleep.Methods: 26 Senior Vipassana meditation practitioners and 23 non-meditating control subjects participated in the study. Whole night polysomnography with lead II ECG were carried out using 32 channel, 2110 digital EEG system (Nihon Kohden, Japan) and with 16 channels Power Lab data acquisition system (AD Instruments, Australia. Differences in sleep variables across sleep cycles among the meditation practitioners and control groups (between groups) were analyzed by two way ANOVA with turkey posthoc test. The heart rate variability (HRV) was assessed during N2 and N3 and REM sleep state across three consecutive sleep cycles. The HRV variables-High frequency power (HF) and low frequency power (LF) density, their normalized units (HFnu and LFnu) and ratio (LF/HF ratio) were compared across sleep cycles using Analysis of variance with repeated measures for within group and 't' test for between groups.Results: Vipassana meditators showed significantly high HFnu irrespective of sleep states across sleep cycles. During REM sleep, as HF nu was concomitantly enhanced along with increased LFnu, the LF/HF ratio was reduced in meditators. In addition, meditators showed distinct sleep architecture with enhanced slow wave sleep and REM sleep states along with significantly reduced intermittent awakenings indicative of proper sleep organisation. Conclusion:Vipassana meditation practice helps to establish a proper cardio autonomic dynamicity during sleep with a persistent increase in parasympathetic activity across sleep states. Such a state of heightened parasympathetic activity especially during REM sleep helps to buffer the sympathetic surges and helps to maintain a proper sympatho-vagal balance essential for quality sleep and cardio protection.

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Central Sympathetic Inhibition Augments Sleep-Related Ultradian Rhythm of Parasympathetic Tone in Patients With Chronic Heart Failure

Cited by 13 publications

References 31 publications

Long-Term Follow-up of the Circadian Rhythm of Heart Rate and Heart Rate Variability in Healthy Elderly Patients

Long-Term Follow-up of the Circadian Rhythm of Heart Rate and Heart Rate Variability in Healthy Elderly Patients

Medetomidine, an .ALPHA.2-Adrenergic Agonist, Activates Cardiac Vagal Nerve Through Modulation of Baroreflex Control

Vipassana Meditation Practices Enhance the Parasympathetic Activity during Sleep: a Case-Control Study of Heart Rate Variability across Sleep Cycles

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