Central Sugar Metabolism and the Cell Wall

Abstract

The human opportunistic pathogen Aspergillus fumigatus is recognized for its versatile cell wall when it comes to remodeling its components in adaptation to external threats, and this remodeling renders it refractory to antifungals targeting cell wall biosynthesis. A specific role for general sugar metabolism in the regulation of the synthesis of cell wall polymers has been previously demonstrated.

Anti-Inflammatory Efficacy of Nanobody Specific to β-Glucan on a Fungal Cell Wall in a Murine Model of Fungal Keratitis

“…The integrity of the fungal cell wall is indispensable for the proliferation and viability of fungi, rendering it a pivotal target for antifungal and anti-inflammatory drugs . Most fungi have a common wall skeleton of β-glucans and chitin .…”